Adult non-communicable disease mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites

ABSTRACT

Glob Health Action

BACKGROUND: Mortality from non-communicable diseases (NCDs) is a major global issue, as other categories of mortality have diminished and life expectancy has increased. The World Health Organization’s Member States have called for a 25% reduction in premature NCD mortality by 2025, which can only be achieved by substantial reductions in risk factors and improvements in the management of chronic conditions. A high burden of NCD mortality among much older people, who have survived other hazards, is inevitable. The INDEPTH Network collects detailed individual data within defined Health and Demographic Surveillance sites. By registering deaths and carrying out verbal autopsies to determine cause of death across many such sites, using standardised methods, the Network seeks to generate population-based mortality statistics that are not otherwise available. OBJECTIVE: To describe patterns of adult NCD mortality from INDEPTH Network sites across Africa and Asia, according to the WHO 2012 verbal autopsy (VA) cause categories, with separate consideration of premature (15-64 years) and older (65+ years) NCD mortality. DESIGN: All adult deaths at INDEPTH sites are routinely registered and followed up with VA interviews. For this study, VA archives were transformed into the WHO 2012 VA standard format and processed using the InterVA-4 model to assign cause of death. Routine surveillance data also provide person-time denominators for mortality rates. RESULTS: A total of 80,726 adult (over 15 years) deaths were documented over 7,423,497 person-years of observation. NCDs were attributed as the cause for 35.6% of these deaths. Slightly less than half of adult NCD deaths occurred in the 15-64 age group. Detailed results are presented by age and sex for leading causes of NCD mortality. Per-site rates of NCD mortality were significantly correlated with rates of HIV/AIDS-related mortality. CONCLUSIONS: These findings present important evidence on the distribution of NCD mortality across a wide range of African and Asian settings. This comes against a background of global concern about the burden of NCD mortality, especially among adults aged under 70, and provides an important baseline for future work.

Streatfield, P. K., Khan, W. A., Bhuiya, A., Hanifi, S. M., Alam, N., Bagagnan, C. H., Sie, A., Zabre, P., Lankoande, B., Rossier, C., Soura, A. B., Bonfoh, B., Kone, S., Ngoran, E. K., Utzinger, J., Haile, F., Melaku, Y. A., Weldearegawi, B., Gomez, P., Jasseh, M., Ansah, P., Debpuur, C., Oduro, A., Wak, G., Adjei, A., Gyapong, M., Sarpong, D., Kant, S., Misra, P., Rai, S. K., Juvekar, S., Lele, P., Bauni, E., Mochamah, G., Ndila, C., Williams, T. N., Laserson, K. F., Nyaguara, A., Odhiambo, F. O., Phillips-Howard, P., Ezeh, A., Kyobutungi, C., Oti, S., Crampin, A., Nyirenda, M., Price, A., Delaunay, V., Diallo, A., Douillot, L., Sokhna, C., Gomez-Olive, F. X., Kahn, K., Tollman, S. M., Herbst, K., Mossong, J., Chuc, N. T., Bangha, M., Sankoh, O. A., Byass, P.

Pages:25365, Volume:7, Edition:11/8/2014, Date,

Link: https://www.ncbi.nlm.nih.gov/pubmed/25377326

Notes:Streatfield, P Kim|Khan, Wasif A|Bhuiya, Abbas|Hanifi, Syed M A|Alam, Nurul|Bagagnan, Cheik H|Sie, Ali|Zabre, Pascal|Lankoande, Bruno|Rossier, Clementine|Soura, Abdramane B|Bonfoh, Bassirou|Kone, Siaka|Ngoran, Eliezer K|Utzinger, Juerg|Haile, Fisaha|Melaku, Yohannes A|Weldearegawi, Berhe|Gomez, Pierre|Jasseh, Momodou|Ansah, Patrick|Debpuur, Cornelius|Oduro, Abraham|Wak, George|Adjei, Alexander|Gyapong, Margaret|Sarpong, Doris|Kant, Shashi|Misra, Puneet|Rai, Sanjay K|Juvekar, Sanjay|Lele, Pallavi|Bauni, Evasius|Mochamah, George|Ndila, Carolyne|Williams, Thomas N|Laserson, Kayla F|Nyaguara, Amek|Odhiambo, Frank O|Phillips-Howard, Penelope|Ezeh, Alex|Kyobutungi, Catherine|Oti, Samuel|Crampin, Amelia|Nyirenda, Moffat|Price, Alison|Delaunay, Valerie|Diallo, Aldiouma|Douillot, Laetitia|Sokhna, Cheikh|Gomez-Olive, F Xavier|Kahn, Kathleen|Tollman, Stephen M|Herbst, Kobus|Mossong, Joel|Chuc, Nguyen T K|Bangha, Martin|Sankoh, Osman A|Byass, Peter|eng|101594/Wellcome Trust/United Kingdom|WT081993MA/Wellcome Trust/United Kingdom|5U22/PS022179_10/PS/NCHHSTP CDC HHS/|098610/Wellcome Trust/United Kingdom|058893/Z/99/A/Wellcome Trust/United Kingdom|091758/Wellcome Trust/United Kingdom|Medical Research Council/United Kingdom|084538/Wellcome Trust/United Kingdom|097318/Wellcome Trust/United Kingdom|U22 PS022179/PS/NCHHSTP CDC HHS/|085477/Z/08/Z/Wellcome Trust/United Kingdom|MC_UP_A900_1123/Medical Research Council/United Kingdom|069683/Z/02/Z/Wellcome Trust/United Kingdom|Research Support, N.I.H., Extramural|Research Support, Non-U.S. Gov’t|Research Support, U.S. Gov’t, P.H.S.|2014/11/08 06:00|Glob Health Action. 2014 Oct 29;7:25365. doi: 10.3402/gha.v7.25365. eCollection 2014.

ISBN: 1654-9880 (Electronic)|1654-9880 (Linking) Permanent ID: PMC4220128 Accession Number: 25377326

Author Address: Matlab HDSS, Bangladesh| International Centre for Diarrhoeal Disease Research, Bangladesh| INDEPTH Network, Accra, Ghana.|International Centre for Diarrhoeal Disease Research, Bangladesh| INDEPTH Network, Accra, Ghana| Bandarban HDSS, Bangladesh.|INDEPTH Network, Accra, Ghana| Chakaria HDSS, Bangladesh| Centre for Equity and Health Systems, International Centre for Diarrhoeal Disease Research, Bangladesh.|INDEPTH Network, Accra, Ghana| AMK HDSS, Bangladesh| Centre for Population, Urbanisation and Climate Change, International Centre for Diarrhoeal Disease Research, Bangladesh.|INDEPTH Network, Accra, Ghana| Nouna HDSS, Burkina Faso| Nouna Health Research Centre, Nouna, Burkina Faso.|INDEPTH Network, Accra, Ghana| Ouagadougou HDSS, Burkina Faso| Institut Superieur des Sciences de la Population, Universite de Ouagadougou, Burkina Faso and Institut d’Etudes Demographique et du parcours de vie, Universite de Geneve, Geneva, Switzerland.|INDEPTH Network, Accra, Ghana| Taabo HDSS, Cote d’Ivoire| , Centre Suisse de Recherches Scientifiques en Cote d’Ivoire, Abidjan, Cote d’Ivoire.|INDEPTH Network, Accra, Ghana| Taabo HDSS, Cote d’Ivoire| , Universite Felix Houphoet-Boigny, Abidjan, Cote d’Ivoire.|INDEPTH Network, Accra, Ghana| Taabo HDSS, Cote d’Ivoire| , Swiss Tropical and Public Health Institute, Basel, Switzerland.|INDEPTH Network, Accra, Ghana| Kilite-Awlaelo HDSS, Ethiopia| Department of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.|INDEPTH Network, Accra, Ghana| Farafenni HDSS, The Gambia| Medical Research Council, The Gambia Unit, Fajara, The Gambia.|INDEPTH Network, Accra, Ghana| Navrongo HDSS, Ghana| Navrongo Health Research Centre, Navrongo, Ghana.|INDEPTH Network, Accra, Ghana| Dodowa HDSS, Ghana| Dodowa Health Research Centre, Dodowa, Ghana.|INDEPTH Network, Accra, Ghana| Dodowa HDSS, Ghana| Ballabgarh HDSS, India.|INDEPTH Network, Accra, Ghana| Ballabgarh HDSS, India| All India Institute of Medical Sciences, New Delhi, India.|INDEPTH Network, Accra, Ghana| Vadu HDSS, India| Vadu Rural Health Program, KEM Hospital Research Centre, Pune, India.|INDEPTH Network, Accra, Ghana| Kilifi HDSS, Kenya| KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.|INDEPTH Network, Accra, Ghana| Kilifi HDSS, Kenya| KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya| Department of Medicine, Imperial College, St. Mary’s Hospital, London, United Kingdom.|INDEPTH Network, Accra, Ghana| Kisumu HDSS, Kenya| KEMRI/CDC Research and Public Health Collaboration and KEMRI Center for Global Health Research, Kisumu, Kenya.|INDEPTH Network, Accra, Ghana| Nairobi HDSS, Kenya| African Population and Health Research Center, Nairobi, Kenya.|INDEPTH Network, Accra, Ghana| Karonga HDSS, Malawi| Karonga Prevention Study, Chilumba, Malawi| London School of Hygiene and Tropical Medicine, London, United Kingdom.|INDEPTH Network, Accra, Ghana| Karonga HDSS, Malawi| Karonga Prevention Study, Chilumba, Malawi.|INDEPTH Network, Accra, Ghana| Niakhar HDSS, Senegal| Institut de Recherche pour le Developpement (IRD), Dakar, Senegal.|INDEPTH Network, Accra, Ghana| Agincourt HDSS, South Africa| MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.|INDEPTH Network, Accra, Ghana| Agincourt HDSS, South Africa| MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa| Umea Centre for Global Health Research, Umea University, Umea, Sweden.|INDEPTH Network, Accra, Ghana| Africa Centre HDSS, South Africa| Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, KwaZulu-Natal, South Africa.|INDEPTH Network, Accra, Ghana| Africa Centre HDSS, South Africa| National Health Laboratory, Surveillance & Epidemiology of Infectious Diseases, Dudelange, Luxembourg.|INDEPTH Network, Accra, Ghana| FilaBavi HDSS, Vietnam| Health System Research, Hanoi Medical University, Hanoi, Vietnam.|INDEPTH Network, Accra, Ghana.|INDEPTH Network, Accra, Ghana| School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa| Hanoi Medical University, Hanoi, Vietnam| osman.sankoh@indepth-network.org.|INDEPTH Network, Accra, Ghana| MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa| WHO Collaborating Centre for Verbal Autopsy, Umea Centre for Global Health Research, Umea University, Umea, Sweden.

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