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Biography
Ambrose is a paediatrician and clinical epidemiologist with a research career spanning more than ten years in epidemiology, implementation science, pragmatic clinical trials, and evidence synthesis with a focus on childhood respiratory infections. Some of his work has ignited debate around the appropriateness of WHO and Kenyan guidelines for the management of pneumonia in children. More recently, he has overseen a large programme of clinical and seroepidemiological surveillance of SARS-CoV-2, contributing towards the few published reports on the unique epidemiology of COVID-19 in Africa.
Current Work
Ambrose currently co-leads the Clinical Information Network. This collaboration of researchers, policymakers, and practising health professionals at 22 Kenyan hospitals has supported the generation and use of routine data to improve care, understand patient outcomes, and evaluate interventions since 2013. Over the last five years, he has championed the regional growth of this Learning Network to Tanzania, where it is currently running under the leadership of the Paediatric Association of Tanzania. Nationally, Ambrose serves on various Ministry of Health technical panels where he has engaged in developing policy and strategy for newborn, child, and adolescent health. He is also the immediate former co-chair, and a member of the Child Health Accountability Tracking (CHAT) Technical Advisory Group convened by WHO and UNICEF. Collaborations;- Other Roles;
- Adjunct Professor (Department of Pediatrics, Stanford University, USA)
- Adjunct Faculty (Institute of Healthcare Management, Strathmore University, Kenya
- Member, Child Health Accountability Tracking (CHAT) Technical Advisory Group (WHO/UNICEF)
- Member, Life Course Quality of Care Metrics Working Group (WHO)
- Member, Child Health Panel of Experts (Ministry of Health, Kenya)
- National Board member and member of the Scientific Committee (Kenya Paediatric Association)
- Member, Research Committee Advisory Board (Kenya Medical Association)
- Member, Keprecon
- Committee member, Population and Public Health Early Career Advisory Group (Wellcome Trust)
Collaborations
Adolfine Hokororo (Bugando Medical Centre, Tanzania), Caroline Mwangi (MoH, Kenya), Charles Opondo (LSHTM), Chris Paton (University of Oxford), Christine Joyce-Lynn (Weil Cornell Medical College), David Gathara (LSHTM), Elizabeth Allen (LSHTM), Evans Kamuri (Kenyatta National Hospital), Francis Wafula (Strathmore University), Fred Were (Keprecon), Geoffrey Omuse (Aga Khan University Hospital), Gilbert Kokwaro (Strathmore University), Heather Zar (University of Cape Town), Ifedayo Adetifa (CDC Nigeria), Jane Chuma (The World Bank Group), Jane Crawley (Oxford University), Jennifer Requejo (UNICEF), Jose Maria Ferer (American Heart Association), Kadondi Kasera (MoH, Kenya), Kathleen Strong (World Health Organization), Kenneth Munge (The World Bank Group), Kim Mulholland (University of Melbourne), Martin Weber (World Health Organization), Mercy Mwangangi (MoH, Kenya), Michael Alfonzo (Weil Cornell Medical College), Moise Muzigaba (World Health Organization), Patrick Amoth (MoH, Kenya), Peter Meaney (Stanford University), Peter Waiswa (Makerere University), Rashid Aman (MoH, Kenya), Richard Lilford (University of Warwick), Sanam Roder-DeWan (The World Bank Group), Segolame Setlhare (American Heart Association), Theopista Masenge (Paediatric Association of Tanzania).Project Research
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Publications
Implementing adaptive e-learning for newborn care in Tanzania: an observational study of provider engagement and knowledge gains.
Meaney, P. A., Hokororo, A., Ndosi, H., Dahlen, A., Jacob, T., Mwanga, J. R., Kalabamu, F. S., Joyce, C. L., Mediratta, R., Rozenfeld, B., Berg, M., Smith, Z. H., Chami, N., Mkopi, N., Mwanga, C., Diocles, E., Agweyu, A.
BMJ Open, (2024). 14:e077834
Latent viral infections as neglected risk factors for long COVID - Authors' reply.
Muller, S. A., Isaaka, L., Mumm, R., Scheidt-Nave, C., Heldt, K., Schuster, A., Abdulaziz, M., El-Bcheraoui, C., Hanefeld, J., Agweyu, A.
Lancet Glob Health, (2024). 12:e198
Advocacy for Better Integration and Use of Child Health Indicators for Global Monitoring.
Strong, K., Requejo, J., Billah, S. M., Schellenberg, J., Munos, M., Lazzerini, M., Agweyu, A., Boschi-Pinto, C., Horiuchi, S., Maiga, A., Weigel, R., Jamaluddine, Z., Black, M., Aboud, F., Sacks, E.
Glob Health Sci Pract, (2023). 11:e2300181
Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review.
Müller, S. A., Isaaka, L., Mumm, R., Scheidt-Nave, C., Heldt, K., Schuster, A., Abdulaziz, M., El Bcheraoui, C., Hanefeld, J., Agweyu, A.
Lancet Glob Health, (2023). 11:e1713-e1724
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study.
Otiende, M., Nyaguara, A., Bottomley, C., Walumbe, D., Mochamah, G., Amadi, D., Nyundo, C., Kagucia, E. W., Etyang, A. O., Adetifa, I. M. O., Brand, S. P. C., Maitha, E., Chondo, E., Nzomo, E., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Ng'ang'a, W., Barasa, E., Tsofa, B., Mwangangi, J., Bejon, P., Agweyu, A., Williams, T. N., Scott, J. A. G.
Nat Commun, (2023). 14:6879
Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review.
Müller, S. A., Isaaka, L., Mumm, R., Scheidt-Nave, C., Heldt, K., Schuster, A., Abdulaziz, M., El Bcheraoui, C., Hanefeld, J., Agweyu, A.
Lancet Glob Health, (2023). 11:e1713-e1724
SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022.
Kagucia, E. W., Ziraba, A. K., Nyagwange, J., Kutima, B., Kimani, M., Akech, D., Ng'oda, M., Sigilai, A., Mugo, D., Karanja, H., Gitonga, J., Karani, A., Toroitich, M., Karia, B., Otiende, M., Njeri, A., Aman, R., Amoth, P., Mwangangi, M., Kasera, K., Ng'ang'a, W., Voller, S., Ochola-Oyier, L. I., Bottomley, C., Nyaguara, A., Munywoki, P. K., Bigogo, G., Maitha, E., Uyoga, S., Gallagher, K. E., Etyang, A. O., Barasa, E., Mwangangi, J., Bejon, P., Adetifa, I. M. O., Warimwe, G. M., Scott, J. A. G., Agweyu, A.
Influenza Other Respir Viruses, (2023). 17:e13173
Symptom prevalence and secondary attack rate of SARS-CoV-2 in rural Kenyan households: A prospective cohort study.
Gallagher, K. E., Nyiro, J., Agoti, C. N., Maitha, E., Nyagwange, J., Karani, A., Bottomley, C., Murunga, N., Githinji, G., Mutunga, M., Ochola-Oyier, L. I., Kombe, I., Nyaguara, A., Kagucia, E. W., Warimwe, G., Agweyu, A., Tsofa, B., Bejon, P., Scott, J. A. G., Nokes, D. J.
Influenza Other Respir Viruses, (2023). 17:e13185
Clinical epidemiology of COVID-19 among hospitalized children in rural western Kenya.
Tsegaye, A. T., Sherry, C., Oduol, C., Otieno, J., Rwigi, D., Masheti, M., Machura, I., Liru, M., Akuka, J., Omedo, D., Symekher, S., Khamadi, S. A., Isaaka, L., Ogero, M., Mumelo, L., Berkley, J. A., Agweyu, A., Walson, J. L., Singa, B. O., Tickell, K. D.
PLOS Glob Public Health, (2023). 3:e0002011
SARS-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021.
Etyang, A. O., Adetifa, I., Omore, R., Misore, T., Ziraba, A. K., Ng'oda, M. A., Gitau, E., Gitonga, J., Mugo, D., Kutima, B., Karanja, H., Toroitich, M., Nyagwange, J., Tuju, J., Wanjiku, P., Aman, R., Amoth, P., Mwangangi, M., Kasera, K., Ng'ang'a, W., Akech, D., Sigilai, A., Karia, B., Karani, A., Voller, S., Agoti, C. N., Ochola-Oyier, L. I., Otiende, M., Bottomley, C., Nyaguara, A., Uyoga, S., Gallagher, K., Kagucia, E. W., Onyango, D., Tsofa, B., Mwangangi, J., Maitha, E., Barasa, E., Bejon, P., Warimwe, G. M., Scott, J. A. G., Agweyu, A.
PLOS Glob Public Health, (2022). 2:e0000883