Publications

Biosciences

Prospective clinical surveillance for severe acute respiratory illness and COVID-19 vaccine effectiveness in Kenyan hospitals during the COVID-19 pandemic.Lucinde RK, Gathuri H, Isaaka L, Ogero M, Mumelo L, Kimego D, Mbevi G, Wanyama C, Otieno EO, Mwakio S, Saisi M, Isinde E, Oginga IN, Wachira A, Manuthu E, Kariuki H, Nyikuli J, Wekesa C, Otedo A, Bosire H, Okoth SB, Ongalo W, Mukabi D, Lusamba W, Muthui B, Adembesa I, Mithi C, Sood M, Ahmed N, Gituma B, Giabe M, Omondi C, Aman R, Amoth P, Kasera K, Were F, Nganga W, Berkley JA, Tsofa B, Mwangangi J, Bejon P, Barasa E, English M, Scott JAG, Akech S, Kagucia EW, Agweyu A, Etyang AO
BMC Infect Dis, (2024). 24:1246

ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria.Adegbola AJ, Ndwiga L, Wamae K, Osoti V, Bolaji OO, Bejon P, Ochola-Oyier LI
Front Genet, (2024). 15:1470156

Molecular xenomonitoring reveals Anopheles funestus and An. rivulorum as the primary vectors of lymphatic filariasis in coastal Kenya.Bartilol B, Babu L, Garama K, Karisa J, Kamau A, Mwandawiro C, Wanjiku C, Mbogo C, Maia M, Mwangangi J, Rono MK
Parasit Vectors, (2024). 17:425

Mosquitocidal efficacy and pharmacokinetics of single-dose ivermectin versus three-day dose regimen for malaria vector control in comparison with albendazole and no treatment: an open-label randomized controlled trial.Kamau Y, Tuwei M, Wanjiku C, Ominde K, Ngama M, Karisa J, Babu L, Muturi M, Mwatasa M, Adetifa J, Kern C, Duthaler U, Hammann F, Rabinovich R, Chaccour C, Maia MF
Int J Infect Dis, (2024). 148:107236

Mosquitocidal efficacy and pharmacokinetics of single-dose ivermectin versus three-day dose regimen for malaria vector control compared with albendazole and no treatment: An open-label randomized controlled trial.Kamau Y, Tuwei M, Wanjiku C, Ominde K, Ngama M, Karisa J, Babu L, Muturi M, Mwatasa M, Adetifa J, Kern C, Duthaler U, Hammann F, Rabinovich R, Chaccour C, Maia MF
Int J Infect Dis, (2024). 148:107236

Antibodies to PfEMP1 and Variant Surface Antigens: Protection after Controlled Human Malaria Infection in Semi-immune Kenyan Adults.Kinyua AW, Turner L, Kimingi HW, Mwai K, Mwikali K, Andisi C, Sim BKL, Bejon P, Kapulu MC, Kinyanjui SM, Lavstsen T, Abdi AI
J Infect, (2024). 89:106252

The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria.Kioko M, Mwangi S, Pance A, Ochola-Oyier LI, Kariuki S, Newton C, Bejon P, Rayner JC, Abdi AI
Sci Adv, (2024). 10:eadl2256

A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda.Ogwang R, Osoti V, Wamae K, Ndwiga L, Muteru K, Ningwa A, Tuju J, Kinyanjui S, Osier F, Marsh K, Bejon P, Idro R, Ochola-Oyier LI
Antimicrob Agents Chemother, (2024). 68:e0157623

Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial).Tiwari R, Tickell KD, Yoshioka E, Otieno J, Shah A, Richardson BA, Keter L, Okello M, Nyabinda C, Trehan I, McGrath CJ, Means AR, Houpt ER, Liu J, Platts-Mills JA, Njunge JM, Rwigi D, Diakhate MM, Nyaoke J, Ochola E, John-Stewart G, Walson JL, Pavlinac PB, Singa BO
BMJ Open, (2024). 14:e079448

Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population.Stejskal L, Thistlethwaite A, Ramirez-Bencomo F, Rashmi S, Harrison O, Feavers IM, Maiden MCJ, Jerse A, Barnes G, Chirro O, Chemweno J, Nduati E, Cehovin A, Tang C, Sanders EJ, Derrick JP
Nat Commun, (2024). 15:6712

Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis.Kioko M, Mwangi S, Njunge JM, Berkley JA, Bejon P, Abdi AI
Mol Neurobiol, (2024). :Online ahead of print

Biomarkers of mortality in adults and adolescents with advanced HIV in sub-Saharan Africa.Riitho V, Connon R, Gwela A, Namusanje J, Nhema R, Siika A, Bwakura-Dangarembizi M, Musiime V, Berkley JA, Szubert AJ, Gibb DM, Walker AS, Klein N, Prendergast AJ
Nat Commun, (2024). 15:5492

Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings.Mugo RM, Rausch S, Musimbi ZD, Strube C, Raulf MK, Landt O, Gichuki PM, Ebner F, Mwacharo J, Odiere MR, Ndungu FM, Njomo DW, Hartmann S
PLoS Negl Trop Dis, (2024). 18:e0012279

Barriers and enablers to the effective implementation of omics research in low- and middle-income countries.Nacis JS, Kamande P, Toni AT, Mudibo E, Musyimi R, Popluechai S, Dailey-Chwalibóg T, Voskuijl W, Dable-Tupas G, Shahid Asmsb Bascos NA, Afroze F, Chisti MJ, Singa B, Ngari M, Tigoi C, Mhango G, Freitag H, Potani I, Mukisa J, Kirolos A, Mutasa K, Ouédraogo LO, Prentice AM, Girma T, Prendergast AJ, Njunge J, Kelly P, Berkley JA, Tickell KD, Gonzales GB
Nat Biotechnol, (2024). 42:988-991

Full-length MSP1 is a major target of protective immunity after controlled human malaria infection.Rosenkranz M, Nkumama IN, Ogwang R, Kraker S, Blickling M, Mwai K, Odera D, Tuju J, Fürle K, Frank R, Chepsat E, Kapulu MC, Study Team CS, Osier FH
Life Sci Alliance, (2024). 7:

Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge.Nkumama IN, Ogwang R, Odera D, Musasia F, Mwai K, Nyamako L, Murungi L, Tuju J, Fürle K, Rosenkranz M, Kimathi R, Njuguna P, Hamaluba M, Kapulu MC, Frank R, Osier FHA
Immunity, (2024). 57:1215-1224

A scoping review of ethics review processes during public health emergencies in Africa.Orievulu K, Hinga A, Nkosi B, Ngwenya N, Seeley J, Akanlu A, Tindana P, Molyneux S, Kinyanjui S, Kamuya D
BMC Med Ethics, (2024). 25:63

Tungiasis among children in Kenya is associated with poor nutrition status, absenteeism, poor school performance and high impact on quality of life.Elson L, Kamau C, Koech S, Muthama C, Gachomba G, Sinoti E, Chondo E, Mburu E, Wakio M, Lore J, Maia M, Adetifa I, Orindi B, Bejon P, Fillinger U
PLoS Negl Trop Dis, (2024). 18:e0011800

Reversible host cell surface remodelling limits immune recognition and maximizes transmission of Plasmodium falciparum gametocytes.Ngotho P, Press KD, Peedell M, Muasya W, Omondi BR, Otoboh SE, Seydel KB, Kapulu M, Laufer M, Taylor T, Bousema T, Marti M
bioRxiv, (2024). :

Severe morbidity and hospital-based mortality from Rift Valley fever disease between November 2017 and March 2020 among humans in Uganda.Anywaine Z, Hansen C, Warimwe GM, Abu-Baker Mustapher G, Nyakarahuka L, Balinandi S, Ario AR, Lutwama JJ, Elliott A, Kaleebu P
Virol J, (2024). 21:104