Phenotype is sustained during hospital readmissions following treatment for complicated severe malnutrition among Kenyan children: A retrospective cohort study


Matern Child Nutr

Hospital readmission is common among children with complicated severe acute malnutrition (cSAM) but not well-characterised. Two distinct cSAM phenotypes, marasmus and kwashiorkor, exist, but their pathophysiology and whether the same phenotype persists at relapse are unclear. We aimed to test the association between cSAM phenotype at index admission and readmission following recovery. We performed secondary data analysis from a multicentre randomised trial in Kenya with 1-year active follow-up. The main outcome was cSAM phenotype upon hospital readmission. Among 1,704 HIV-negative children with cSAM discharged in the trial, 177 children contributed a total of 246 readmissions with cSAM. cSAM readmission was associated with age<12 months (p = .005), but not site, sex, season, nor cSAM phenotype. Of these, 42 children contributed 44 readmissions with cSAM that occurred after a monthly visit when SAM was confirmed absent (cSAM relapse). cSAM phenotype was sustained during cSAM relapse. The adjusted odds ratio for presenting with kwashiorkor during readmission after kwashiorkor at index admission was 39.3 [95% confidence interval (95% CI) [2.69, 1,326]; p = .01); and for presenting with marasmus during readmission after kwashiorkor at index admission was 0.02 (95% CI [0.001, 0.037]; p = .01). To validate this finding, we examined readmissions to Kilifi County Hospital, Kenya occurring at least 2 months after an admission with cSAM. Among 2,412 children with cSAM discharged alive, there were 206 readmissions with cSAM. Their phenotype at readmission was significantly influenced by their phenotype at index admission (p < .001). This is the first report describing the phenotype and rate of cSAM recurrence. Gonzales, G. B., Ngari, M. M., Njunge, J. M., Thitiri, J., Mwalekwa, L., Mturi, N., Mwangome, M. K., Ogwang, C., Nyaguara, A., Berkley, J. A.

Pages:e12913, Volume:16, Edition:11/23/2019, Date,Apr


Notes:Gonzales, Gerard Bryan|Ngari, Moses M|Njunge, James M|Thitiri, Johnstone|Mwalekwa, Laura|Mturi, Neema|Mwangome, Martha K|Ogwang, Caroline|Nyaguara, Amek|Berkley, James A|eng|WT_/Wellcome Trust/United Kingdom|MR/M007367/1/MRC_/Medical Research Council/United Kingdom|MR/R002738/1/MRC_/Medical Research Council/United Kingdom|WT083579MA/WT_/Wellcome Trust/United Kingdom|Multicenter Study|Randomized Controlled Trial|Research Support, Non-U.S. Gov’t|England|2019/11/23 06:00|Matern Child Nutr. 2020 Apr;16(2):e12913. doi: 10.1111/mcn.12913. Epub 2019 Nov 22.

ISBN: 1740-8709 (Electronic)|1740-8695 (Linking) Permanent ID: PMC7083470 Accession Number: 31756291

Author Address: Laboratory of Gastroenterology, Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.|VIB Inflammation Research Centre, Ghent, Belgium.|Department of Translational Medicine, Hospital for Sick Children, Toronto, Canada.|The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.|KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.|Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.