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Bioscience
Prof. Kevin Marsh
Principal Investigator
Project Research
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Biography
Kevin Marsh was Director of the KEMRI Wellcome Trust Research Programme from its inception untill August 2014. He qualified in medicine at the University of Liverpool in 1978 and after undertaking specialist training as a physician began his research career at the Medical Research Council Unit in the Gambia working on the immunology of malaria. From 1985-89 he was at the Institute of Molecular Medicine in Oxford and in 1989 established with colleagues a series of research projects on the clinical epidemiology and immunology of malaria at Kilifi on the Kenyan coast. These have subsequently developed into the current programme. The programme’s research is multidisciplinary and ranges from community based epidemiology, though bedside clinical research and basic sciences to social science and health systems and policy research applied to all major causes of morbidity in east Africa. Kevin is also professor of tropical medicine at the University of Oxford and chair of the Oxford Tropical Network. He is chair of the WHO Malaria Policy Advisory Committee recently established to advise the Director general of the WHO on malaria. Professor Marsh has a particular interest in developing and strengthening research capacity and scientific leadership in Africa. He is a member of a number of international advisory committees relating to malaria and to global health research. Kevin Marsh has a broad interest in clinical, epidemiological and immunological aspects of malaria. His specialist interest is in how people acquire immunity to malaria and the team he established in Kilifi have made major contributions to this field. He is currently leading the development of a programme of experimental malaria challenge to support vaccine development and testing in Nairobi.
Current Work
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Project Research
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Publications
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.
Odera, D. O., Tuju, J., Mwai, K., Nkumama, I. N., Fürle, K., Chege, T., Kimathi, R., Diehl, S., Musasia, F. K., Rosenkranz, M., Njuguna, P., Hamaluba, M., Kapulu, M. C., Frank, R., Osier, F. H. A., Abdi, A. I., Chi, P. C., de Laurent, Z., Jao, I., Kamuya, D., Kamuyu, G., Makale, J., Murungi, L., Musyoki, J., Muthui, M., Mwacharo, J., Kariuki, S., Mwanga, D., Mwongeli, J., Ndungu, F., Njue, M., Nyangweso, G., Kimani, D., Ngoi, J. M., Musembi, J., Ngoto, O., Otieno, E., Ooko, M., Shangala, J., Wambua, J., Mohammed, K. S., Omuoyo, D., Mosobo, M., Kibinge, N., Kinyanjui, S., Bejon, P., Lowe, B., Marsh, K., Marsh, V., Abebe, Y., Billingsley, P. F., Sim, B. K. L., Hoffman, S. L., James, E. R., Richie, T. L., Audi, A., Olewe, F., Oloo, J., Ongecha, J., Ongas, M. O., Koskei, N., Bull, P. C., Hodgson, S. H., Kivisi, C., Imwong, M., Murphy, S. C., Ogutu, B., Tarning, J., Winterberg, M., Williams, T. N.
Sci Transl Med, (2023). 15:eabn5993
Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples.
Abdel Hamid, M. M., Abdelraheem, M. H., Acheampong, D. O., Ahouidi, A., Ali, M., Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andagalu, B., Anderson, T., Andrianaranjaka, V., Aniebo, I., Aninagyei, E., Ansah, F., Ansah, P. O., Apinjoh, T., Arnaldo, P., Ashley, E., Auburn, S., Awandare, G. A., Ba, H., Baraka, V., Barry, A., Bejon, P., Bertin, G. I., Boni, M. F., Borrmann, S., Bousema, T., Bouyou-Akotet, M., Branch, O., Bull, P. C., Cheah, H., Chindavongsa, K., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D. J., Corredor, V., Courtier, E., Craig, A., D'Alessandro, U., Dama, S., Day, N., Denis, B., Dhorda, M., Diakite, M., Djimde, A., Dolecek, C., Dondorp, A., Doumbia, S., Drakeley, C., Drury, E., Duffy, P., Echeverry, D. F., Egwang, T. G., Enosse, S. M. M., Erko, B., Fairhurst, R. M., Faiz, A., Fanello, C. A., Fleharty, M., Forbes, M., Fukuda, M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Harrison, G. L. A., Healy, S. A., Hendry, J. A., Hernandez-Koutoucheva, A., Hien, T. T., Hill, C. A., Hombhanje, F., Hott, A., Htut, Y., Hussein, M., Imwong, M., Ishengoma, D., Jackson, S. A., Jacob, C. G., Jeans, J., Johnson, K. J., Kamaliddin, C., Kamau, E., Keatley, J., Kochakarn, T., Konate, D. S., Konaté, A., Kone, A., Kwiatkowski, D. P., Kyaw, M. P., Kyle, D., Lawniczak, M., Lee, S. K., Lemnge, M., Lim, P., Lon, C., Loua, K. M., Mandara, C. I., Marfurt, J., Marsh, K., Maude, R. J., Mayxay, M., Maïga-Ascofaré, O., Miotto, O., Mita, T., Mobegi, V., Mohamed, A. O., Mokuolu, O. A., Montgomery, J., Morang'a, C. M., Mueller, I., Murie, K., Newton, P. N., Ngo Duc, T., Nguyen, T., Nguyen, T. N., Nguyen Thi Kim, T., Nguyen Van, H., Noedl, H., Nosten, F., Noviyanti, R., Ntui, V. N., Nzila, A., Ochola-Oyier, L. I., Ocholla, H., Oduro, A., Omedo, I., Onyamboko, M. A., Ouedraogo, J. B., Oyebola, K., Oyibo, W. A., Pearson, R., Peshu, N., Phyo, A. P., Plowe, C. V., Price, R. N., Pukrittayakamee, S., Quang, H. H., Randrianarivelojosia, M., Rayner, J. C., Ringwald, P., Rosanas-Urgell, A., Rovira-Vallbona, E., Ruano-Rubio, V., Ruiz, L., Saunders, D., Shayo, A., Siba, P., Simpson, V. J., Sissoko, M. S., Smith, C., Su, X. Z., Sutherland, C., Takala-Harrison, S., Talman, A., Tavul, L., Thanh, N. V., Thathy, V., Thu, A. M., Toure, M., Tshefu, A., Verra, F., Vinetz, J., Wellems, T. E., Wendler, J., White, N. J., Whitton, G., Yavo, W., van der Pluijm, R. W.
Wellcome Open Res, (2023). 8:22
Mortality in rural coastal Kenya measured using the Kilifi Health and Demographic Surveillance System: a 16-year descriptive analysis [version 2; peer review: 1 approved, 1 approved with reservations].
Otiende, M., Bauni, E., Nyaguara, A., Amadi, D., Nyundo, C., Tsory, E., Walumbe, D., Kinuthia, M., Kihuha, N., Kahindi, M., Nyutu, G., Moisi, J., Deribew, A., Agweyu, A., Marsh, K., Tsofa, B., Bejon, P., Bottomley, C., Williams, T. N., Scott, J. A. G.
Wellcome Open Research, (2023). 6:
Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated With Onchocerca volvulus.
Mazumder, R., Lubowa, S. K., Salamon, N., Jackson, N. J., Kawooya, M., Akun, P. R., Anguzu, R., Ogwang, R. J., Kubofcik, J., Nutman, T., Marsh, K., Newton, C., Vincent, A., Idro, R.
Neurol Neuroimmunol Neuroinflamm, (2023). 10:e200074
Malaria protection due to sickle haemoglobin depends on parasite genotype.
Band, G., Leffler, E. M., Jallow, M., Sisay-Joof, F., Ndila, C. M., Macharia, A. W., Hubbart, C., Jeffreys, A. E., Rowlands, K., Nguyen, T., Goncalves, S., Ariani, C. V., Stalker, J., Pearson, R. D., Amato, R., Drury, E., Sirugo, G., d'Alessandro, U., Bojang, K. A., Marsh, K., Peshu, N., Saelens, J. W., Diakite, M., Taylor, S. M., Conway, D. J., Williams, T. N., Rockett, K. A., Kwiatkowski, D. P.
Nature, (2022). 602:106-111
10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity.
Addy, J. W. G., Bediako, Y., Ndungu, F. M., Valetta, J. J., Reid, A. J., Mwacharo, J., Ngoi, J. M., Wambua, J., Otieno, E., Musyoki, J., Said, K., Berriman, M., Marsh, K., Bejon, P., Recker, M., Langhorne, J.
Wellcome Open Res, (2021). 6:79
Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial.
Mzumara, G., Leopold, S., Marsh, K., Dondorp, A., Ohuma, E. O., Mukaka, M.
Malar J, (2021). 20:282
An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples.
MalariaGen., Ahouidi, A., Ali, M., Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T. J. C., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E. A., Auburn, S., Awandare, G. A., Ba, H., Baraka, V., Barry, A. E., Bejon, P., Bertin, G. I., Boni, M. F., Borrmann, S., Bousema, T., Branch, O., Bull, P. C., Busby, G. B. J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N. P., Denis, B., Diakite, M., Djimde, A., Dolecek, C., Dondorp, A. M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D. F., Egwang, T. G., Erko, B., Fairhurst, R. M., Faiz, A., Fanello, C. A., Fukuda, M. M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W. L., Harrison, G. L. A., Hart, L., Henrichs, C., Hien, T. T., Hill, C. A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D. S., Jackson, S. A., Jacob, C. G., Jeffery, B., Jeffreys, A. E., Johnson, K. J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konate, A., Kwiatkowski, D. P., Kyaw, M. P., Lim, P., Lon, C., Loua, K. M., Maiga-Ascofare, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O. A., Montgomery, J., Mueller, I., Newton, P. N., Nguyen, T., Nguyen, T. N., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., Ochola-Oyier, L. I., Ocholla, H., Oduro, A., Omedo, I., Onyamboko, M. A., Ouedraogo, J. B., Oyebola, K., Pearson, R. D., Peshu, N., Phyo, A. P., Plowe, C. V., Price, R. N., Pukrittayakamee, S., Randrianarivelojosia, M., Rayner, J. C., Ringwald, P., Rockett, K. A., Rowlands, K., Ruiz, L., Saunders, D., Shayo, A., Siba, P., Simpson, V. J., Stalker, J., Su, X. Z., Sutherland, C., Takala-Harrison, S., Tavul, L., Thathy, V., Tshefu, A., Verra, F., Vinetz, J., Wellems, T. E., Wendler, J., White, N. J., Wright, I., Yavo, W., Ye, H.
Wellcome Open Res, (2021). 6:42
Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda-Clinical, EEG and Brain Imaging Features.
Ogwang, R., Ningwa, A., Akun, P., Bangirana, P., Anguzu, R., Mazumder, R., Salamon, N., Henning, O. J., Newton, C. R., Abbo, C., Mwaka, A. D., Marsh, K., Idro, R.
Front Neurol, (2021). 12:687281
Equity for excellence in academic institutions: a manifesto for change.
Wedekind, L., Noe, A., Mokaya, J., Tamandjou, C., Kapulu, M., Ruecker, A., Kestelyn, E., Zimba, M., Khatamzas, E., Eziefula, A. C., Mackintosh, C. L., Nascimento, R., Ariana, P., Best, D., Gibbs, E., Dunachie, S., Hadley, G., Ravenswood, H., Young, B., Kamau, C., Marsh, K., McShane, H., Hale, R., McPhilbin, E., Ovseiko, P. V., Oxford Equity in Academia, consortium., Surender, R., Worland, C., White, L. J., Matthews, P. C.
Wellcome Open Res, (2021). 6:142