Abstract

New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March-May 2023

Mwanga MJ, Lambisia AW, Morobe JM, Murunga N, Moraa E, Ndwiga L, Cheruiyot R, Musyoki J, Mutunga M, Guzman-Rincon LM, Sande C, Mwangangi J, Bejon P, Ochola-Oyier LI, Nokes DJ, Agoti CN, Nyiro J, Githinji G
Emerg Infect Dis. 2023;29

Permenent descriptor
https://doi.org/10.3201/eid2911.230894


We report a newly emerged SARS-CoV-2 Omicron subvariant FY.4 that has mutations Y451H in spike and P42L in open reading frame 3a proteins. FY.4 emergence coincided with increased SARS-CoV-2 cases in coastal Kenya during April-May 2023. Continued SARS-CoV-2 genomic surveillance is needed to identify new lineages to inform COVID-19 outbreak prevention.

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Key Terms
Covid-19 | Fy.4 | Kenya | Kilifi | Omicron | Sars | SARS-CoV-2 | coronavirus | coronavirus disease | respiratory infections (Source: Medline)
Funded by
This work was supported by the New Variant Assessment Programme, a UK Health Security Agency program funded by the UK Department of Health and Social Care as a global initiative to strengthen genomic surveillance for pandemic preparedness and response to emerging and priority infectious diseases; the UK National Institute for Health and Care Research (project references 17/63/82 and 16/136/33) that uses aid from the UK government to support global health research; UK Foreign, Commonwealth and Development Office, and The Wellcome Trust, UK (grant nos. 220985/Z/20/Z and 226002/A/22/Z).
External Sources
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