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Prof Anthony Scott
Principal Investigator
Project Research
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Biography
I am a clinical epidemiologist with a specific focus on infectious diseases and vaccines. I trained in clinical medicine at Oxford University, in infectious diseases in London and Newcastle and in epidemiology at the London School of Hygiene & Tropical Medicine (LSHTM). I joined the Programme in 1993 and I was based at the University of Oxford for 15 years before taking up my current position at LSHTM as Professor of Vaccine Epidemiology.
Current Work
My work has explored the aetiology of pneumonia in children and adults, the incidence of bacterial invasive diseases in children and the impact of conjugate vaccines against H. influenzae type b and pneumococcus. I have run trials of different types of vaccines against pneumococcus, in different schedules (e.g. for neonates) and different doses and I have established various systems of public health surveillance against invasive bacterial disease and SARS-CoV-2. With Tom Williams I set up the Kilifi Health and Demographic Surveillance System (KHDSS) in 2000 and I have worked with many internal and external collaborators to estimate cause specific morbidity and mortality in the KDHSS. Research Group - Katherine Gallagher - Wangeci Kagucia - Esther Muthumbi - John Ojal Other Roles; Director of the Health Protection Research Unit in Immunisation, London School of Hygiene & Tropical Medicine Policy roles: Member – Joint Committee on Vaccination and Immunisation (JCVI) UK Member – World Health Organization Strategic Advisory Group of Experts on Immunisation (WHO SAGE)Collaborations
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Project Research
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Publications
Age-dependent acquisition of IgG antibodies to Shigella serotypes-a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination.
Kapulu, M. C., Muthumbi, E., Otieno, E., Rossi, O., Ferruzzi, P., Necchi, F., Acquaviva, A., Martin, L. B., Orindi, B., Mwai, K., Kibet, H., Mwanzu, A., Bigogo, G. M., Verani, J. R., Mbae, C., Nyundo, C., Agoti, C. N., Nakakana, U. N., Conti, V., Bejon, P., Kariuki, S., Scott, J. A. G., Micoli, F., Podda, A.
Front Immunol, (2024). 15:1340425
Identifying delays in healthcare seeking and provision: The Three Delays-in-Healthcare and mortality among infants and children aged 1-59 months.
Garcia Gomez, E., Igunza, K. A., Madewell, Z. J., Akelo, V., Onyango, D., El Arifeen, S., Gurley, E. S., Hossain, M. Z., Chowdhury, M. A. I., Islam, K. M., Assefa, N., Scott, J. A. G., Madrid, L., Tilahun, Y., Orlien, S., Kotloff, K. L., Tapia, M. D., Keita, A. M., Mehta, A., Magaço, A., Torres-Fernandez, D., Nhacolo, A., Bassat, Q., Mandomando, I., Ogbuanu, I., Cain, C. J., Luke, R., Kamara, S. I. B., Legesse, H., Madhi, S., Dangor, Z., Mahtab, S., Wise, A., Adam, Y., Whitney, C. G., Mutevedzi, P. C., Blau, D. M., Breiman, R. F., Tippett Barr, B. A., Rees, C. A.
PLOS Glob Public Health, (2024). 4:e0002494
Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management.
Gallagher, K. E., Awori, J. O., Knoll, M. D., Rhodes, J., Higdon, M. M., Hammitt, L. L., Prosperi, C., Baggett, H. C., Brooks, W. A., Fancourt, N., Feikin, D. R., Howie, S. R. C., Kotloff, K. L., Tapia, M. D., Levine, O. S., Madhi, S. A., Murdoch, D. R., O'Brien, K. L., Thea, D. M., Baillie, V. L., Ebruke, B. E., Kamau, A., Moore, D. P., Mwananyanda, L., Olutunde, E. O., Seidenberg, P., Sow, S. O., Thamthitiwat, S., Scott, J. A. G.
PLoS One, (2024). 19:e0297159
Burden of child mortality from malaria in high endemic areas: Results from the CHAMPS network using minimally invasive tissue sampling.
Ogbuanu, I. U., Otieno, K., Varo, R., Sow, S. O., Ojulong, J., Duduyemi, B., Kowuor, D., Cain, C. J., Rogena, E. A., Onyango, D., Akelo, V., Tippett Barr, B. A., terKuile, F., Kotloff, K. L., Tapia, M. D., Keita, A. M., Juma, J., Assefa, N., Assegid, N., Acham, Y., Madrid, L., Scott, J. A. G., Arifeen, S. E., Gurley, E. S., Mahtab, S., Dangor, Z., Wadula, J., Dutoit, J., Madhi, S. A., Mandomando, I., Torres-Fernandez, D., Kincardett, M., Mabunda, R., Mutevedzi, P., Madewell, Z. J., Blau, D. M., Whitney, C. G., Samuels, A. M., Bassat, Q.
J Infect, (2024). S0163-4453:00025-2
Post-mortem investigation of deaths due to pneumonia in children aged 1-59 months in sub-Saharan Africa and South Asia from 2016 to 2022: an observational study.
Mahtab, S., Blau, D. M., Madewell, Z. J., Ogbuanu, I., Ojulong, J., Lako, S., Legesse, H., Bangura, J. S., Bassat, Q., Mandomando, I., Xerinda, E., Fernandes, F., Varo, R., Sow, S. O., Kotloff, K. L., Tapia, M. D., Keita, A. M., Sidibe, D., Onyango, D., Akelo, V., Gethi, D., Verani, J. R., Revathi, G., Scott, J. A. G., Assefa, N., Madrid, L., Bizuayehu, H., Tirfe, T. T., El Arifeen, S., Gurley, E. S., Islam, K. M., Alam, M., Zahid Hossain, M., Dangor, Z., Baillie, V. L., Hale, M., Mutevedzi, P., Breiman, R. F., Whitney, C. G., Madhi, S. A.
Lancet Child Adolesc Health, (2024). 8:201-213
Child deaths caused by Klebsiella pneumoniae in sub-Saharan Africa and south Asia: a secondary analysis of Child Health and Mortality Prevention Surveillance (CHAMPS) data.
Verani, J. R., Blau, D. M., Gurley, E. S., Akelo, V., Assefa, N., Baillie, V., Bassat, Q., Berhane, M., Bunn, J., Cossa, A. C. A., El Arifeen, S., Gunturu, R., Hale, M., Igunza, A., Keita, A. M., Kenneh, S., Kotloff, K. L., Kowuor, D., Mabunda, R., Madewell, Z. J., Madhi, S., Madrid, L., Mahtab, S., Miguel, J., Murila, F. V., Ogbuanu, I. U., Ojulong, J., Onyango, D., Oundo, J. O., Scott, J. A. G., Sow, S., Tapia, M., Traore, C. B., Velaphi, S., Whitney, C. G., Mandomando, I., Breiman, R. F.
Lancet Microbe, (2024). 5:e131-e141
Where do those data go? Reuse of screening results from clinical trials to estimate population prevalence of HBV infection in adults in Kilifi, Kenya.
Downs, L. O., Campbell, C., Abouyannis, M., Otiende, M., Kapulu, M., Obiero, C. W., Hamaluba, M., Ngetsa, C., Andersson, M. I., Githinji, G., Warimwe, G., Baisley, K., Scott, J. A. G., Matthews, P. C., Etyang, A.
J Virus Erad, (2023). 9:100355
Stillbirths and Neonatal Deaths Caused by Group B Streptococcus in Africa and South Asia Identified Through Child Health and Mortality Prevention Surveillance (CHAMPS).
Mahtab, S., Madewell, Z. J., Madhi, S. A., Wise, A., Swart, P. J., Velaphi, S., Mandomando, I., Bramugy, J., Mabunda, R., Xerinda, E., Scott, A. G., Assefa, N., Madrid, L., Bweihun, M., Temesgen, F., Onyango, D., Akelo, V., Oliech, R., Otieno, P., Verani, J. R., Arifeen, S. E., Gurley, E. S., Alam, M., Rahman, A., Hossain, M. Z., Sow, S., Kotloff, K., Tapia, M., Keita, A. M., Sanogo, D., Ogbuanu, I., Ojulong, J., Lako, S., Ita, O., Kaluma, E., Wilson, T., Mutevedzi, P., Barr, B. A. T., Whitney, C. G., Blau, D. M., Bassat, Q.
Open Forum Infect Dis, (2023). 10:ofad356
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study.
Otiende, M., Nyaguara, A., Bottomley, C., Walumbe, D., Mochamah, G., Amadi, D., Nyundo, C., Kagucia, E. W., Etyang, A. O., Adetifa, I. M. O., Brand, S. P. C., Maitha, E., Chondo, E., Nzomo, E., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Ng'ang'a, W., Barasa, E., Tsofa, B., Mwangangi, J., Bejon, P., Agweyu, A., Williams, T. N., Scott, J. A. G.
Nat Commun, (2023). 14:6879
The epidemiology of fecal carriage of nontyphoidal Salmonella among healthy children and adults in three sites in Kenya.
Muthumbi, E. M., Mwanzu, A., Mbae, C., Bigogo, G., Karani, A., Mwarumba, S., Verani, J. R., Kariuki, S., Scott, J. A. G.
PLoS Negl Trop Dis, (2023). 17:e0011716