Tom Williams

Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.Onyamboko MA Olupot-Olupot P Were W Namayanja C Onyas P Titin H Baseke J Muhindo R Kayembe DK Ndjowo PO Basara BB Okalebo CB Williams TN Uyoga S Taya C Bamisaiye A Fanello C Maitland K Day NPJ Taylor WRJ Mukaka M
BMC Med, (2023). 21:397

Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria.Mukaka M Onyamboko MA Olupot-Olupot P Peerawaranun P Suwannasin K Pagornrat W Kouhathong J Madmanee W Were W Namayanja C Onyas P Titin H Baseke J Muhindo R Kayembe DK Ndjowo PO Basara BB Bongo GS Okalebo CB Abongo G Uyoga S Williams TN Taya C Dhorda M Dondorp AM Waithira N Imwong M Maitland K Fanello C Day NPJ Tarning J White NJ Taylor WRJ
EBioMedicine, (2023). 96:104805

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.Opi DH Ndila CM Uyoga S Macharia AW Fennell C Ochola LB Nyutu G Siddondo BR Ojal J Shebe M Awuondo KO Mturi N Peshu N Tsofa B Band G Maitland K Kwiatkowski DP Rockett KA Williams TN Rowe JA
PLoS Genet, (2023). 19:e1010910

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.Olupot-Olupot P Okiror W Mnjalla H Muhindo R Uyoga S Mpoya A Williams TN terHeine R Burger DM Urban B Connon R George EC Gibb DM Walker AS Maitland K
Wellcome Open Res, (2023). 6:161

The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study.Kariuki SN Macharia AW Makale J Nyamu W Hoffman SL Kapulu MC Bejon P Rayner JC Williams TN Chmi-Sika Study Team
Elife, (2023). 12:

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.Odera DO Tuju J Mwai K Nkumama IN Furle K Chege T Kimathi R Diehl S Musasia FK Rosenkranz M Njuguna P Hamaluba M Kapulu MC Frank R Chmi-Sika Study Team Osier FHA Abdi AI Chi PC de Laurent Z Jao I Kamuya D Kamuyu G Makale J Murungi L Musyoki J Muthui M Mwacharo J Kariuki S Mwanga D Mwongeli J Ndungu F Njue M Nyangweso G Kimani D Ngoi JM Musembi J Ngoto O Otieno E Ooko M Shangala J Wambua J Mohammed KS Omuoyo D Mosobo M Kibinge N Kinyanjui S Bejon P Lowe B Marsh K Marsh V Abebe Y Billingsley PF Sim BKL Hoffman SL James ER Richie TL Audi A Olewe F Oloo J Ongecha J Ongas MO Koskei N Bull PC Hodgson SH Kivisi C Imwong M Murphy SC Ogutu B Tarning J Winterberg M Williams TN
Sci Transl Med, (2023). 15:eabn5993

Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial.Taylor WR Olupot-Olupot P Onyamboko MA Peerawaranun P Weere W Namayanja C Onyas P Titin H Baseke J Muhindo R Kayembe DK Ndjowo PO Basara BB Bongo GS Okalebo CB Abongo G Uyoga S Williams TN Taya C Dhorda M Tarning J Dondorp AM Waithira N Fanello C Maitland K Mukaka M Day NJP
Lancet Infect Dis, (2023). 23:471-483

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.Olupot-Olupot P Tomlinson G Williams TN Tshilolo L Santos B Smart LR McElhinney K Howard TA Aygun B Stuber SE Lane A Latham TS Ware RE
Blood, (2023). 141:1402-1410

The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia.Njunge JM Tickell K Diallo AH Sayeem Bin Shahid ASM Gazi MA Saleem A Kazi Z Ali S Tigoi C Mupere E Lancioni CL Yoshioka E Chisti MJ Mburu M Ngari M Ngao N Gichuki B Omer E Gumbi W Singa B Bandsma R Ahmed T Voskuijl W Williams TN Macharia A Makale J Mitchel A Williams J Gogain J Janjic N Mandal R Wishart DS Wu H Xia L Routledge M Gong YY Espinosa C Aghaeepour N Liu J Houpt E Lawley TD Browne H Shao Y Rwigi D Kariuki K Kaburu T Uhlig HH Gartner L Jones K Koulman A Walson J Berkley J
Gates Open Res, (2022). 6:77

Substantial misdiagnosis of severe malaria in African children.White NJ Watson JA Uyoga S Williams TN Maitland KM
Lancet, (2022). 400:807

The significance of spleen size in children with sickle cell anemia.Nardo-Marino A Glenthoj A Brewin JN Petersen J Braunstein TH Kurtzhals JAL Williams TN Rees DC
Am J Hematol, (2022). 97:1520-1528

BIRC6 modifies risk of invasive bacterial infection in Kenyan children.Gilchrist JJ Kariuki SN Watson JA Band G Uyoga S Ndila CM Mturi N Mwarumba S Mohammed S Mosobo M Alasoo K Rockett KA Mentzer AJ Kwiatkowski DP Hill AVS Maitland K Scott JAG Williams TN
Elife, (2022). 11:

Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations.Watson JA Uyoga S Wanjiku P Makale J Nyutu GM Mturi N George EC Woodrow CJ Day NPJ Bejon P Opoka RO Dondorp AM John CC Maitland K Williams TN White NJ
Sci Transl Med, (2022). 14:eabn5040

Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria.Musasia FK Nkumama IN Frank R Kipkemboi V Schneider M Mwai K Odera DO Rosenkranz M F├╝rle K Kimani D Tuju J Njuguna P Hamaluba M Kapulu MC Wardemann H Abdi AI Abebe Y Bejon P Billingsley PF Bull PC de Laurent Z Hoffman SL James ER Kariuki S Kimathi R Kinyanjui S Kivisi C Makale J Marsh K Mohammed KS Mosobo M Musembi J Musyoki J Muthui M Mwacharo J Ndungu F Ngoi JM Ngoto O Ogutu B Olewe F Omuoyo D OngÔÇÖecha J Otieno E Shangala J Sim BKL Richie TL Wambua J Williams TN Osier Faith HA
Nature Communications, (2022). 13:4098

Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT).Uyoga S Olupot-Olupot P Connon R Kiguli S Opoka RO Alaroker F Muhindo R Macharia AW Dondorp AM Gibb DM Walker AS George EC Maitland K Williams TN
Lancet Child Adolesc Health, (2022). 6:606-613

The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria.Uyoga S Watson JA Wanjiku P Rop JC Makale J Macharia AW Kariuki SN Nyutu GM Shebe M Mosobo M Mturi N Rockett KA Woodrow CJ Dondorp AM Maitland K White NJ Williams TN
Nat Commun, (2022). 13:3307

Automating Pitted Red Blood Cell Counts Using Deep Neural Network Analysis: A New Method for Measuring Splenic Function in Sickle Cell Anaemia.Nardo-Marino A Braunstein TH Petersen J Brewin JN Mottelson MN Williams TN Kurtzhals JAL Rees DC Glenthoj A
Front Physiol, (2022). 13:859906

Vitamin D Deficiency and Its Association with Iron Deficiency in African Children.Mogire RM Muriuki JM Morovat A Mentzer AJ Webb EL Kimita W Ndungu FM Macharia AW Cutland CL Sirima SB Diarra A Tiono AB Lule SA Madhi SA Prentice AM Bejon P Pettifor JM Elliott AM Adeyemo A Williams TN Atkinson SH
Nutrients, (2022). 14:

Filling the data gaps on sickle cell anaemia in sub-Saharan Africa.Williams TN
Lancet Haematol, (2022). 9:e172-e173

Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial.George EC Uyoga S M'Baya B Kyeyune Byabazair D Kiguli S Olupot-Olupot P Opoka RO Chagaluka G Alaroker F Williams TN Bates I Mbanya D Gibb DM Walker AS Maitland K Tract trial study group
Lancet Glob Health, (2022). 10:e360-e368