biosciences/Wellcome Open Res

An optimization of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams.Mohammed KS, de Laurent ZR, Omuoyo DO, Lewa C, Gicheru E, Cheruiyot R, Bartilol B, Mutua S, Musyoki J, Gumba H, Mwacharo J, Riako D, Mwangi SJ, Gichuki BM, Nyamako L, Karani A, Karanja H, Mugo D, Gitonga JN, Njuguna S, Gumbi W, Tawa B, Tendwa M, Cheruiyot W, Sein Y, Nyambu JK, Patta SO, Thani TS, Maitha EK, Kitole B, Mwakinangu MS, Muslih BS, Otieno JO, Nyiro JU, Kiyuka P, Ndwiga L, Wamae K, Kimani D, Makale J, Morobe JM, Osoti V, Lambisia AW, Odundo C, Mwarumba S, Mutunga M, Bejon P, Tsofa B, Agoti CN, Ochola-Oyier LI
Wellcome Open Res, (2020). 5:162

Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study.Njunge JM, Gonzales GB, Ngari MM, Thitiri J, Bandsma RHJ, Berkley JA
Wellcome Open Res, (2020). 5:248

Plasma calprotectin as a biomarker of mortality at antiretroviral treatment initiation in advanced HIV - pilot study.Kamau FW, Gwela A, Nyerere AK, Riitho V, Njunge JM, Ngari MM, Prendergast AJ, Berkley JA
Wellcome Open Res, (2020). 5:46

Effectiveness of Rotarix ((R)) vaccine in Africa in the first decade of progressive introduction, 2009-2019: systematic review and meta-analysis.Murunga N, Otieno PG, Maia M, Agoti CN
Wellcome Open Res, (2020). 5:187

Pooled testing conserves SARS-CoV-2 laboratory resources and improves test turn-around time: experience on the Kenyan Coast.Agoti CN, Mutunga M, Lambisia AW, Kimani D, Cheruiyot R, Kiyuka P, Lewa C, Gicheru E, Tendwa M, Said Mohammed K, Osoti V, Makale J, Tawa B, Odundo C, Cheruiyot W, Nyamu W, Gumbi W, Mwacharo J, Nyamako L, Otieno E, Amadi D, Thoya J, Karani A, Mugo D, Musyoki J, Gumba H, Mwarumba S, Gichuki BM, Njuguna S, Riako D, Mutua S, Gitonga JN, Sein Y, Bartilol B, Mwangi SJ, Omuoyo DO, Morobe JM, de Laurent ZR, Bejon P, Ochola-Oyier LI, Tsofa B
Wellcome Open Res, (2020). 5:186

Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children.Abuga KM, Rockett KA, Muriuki JM, Koch O, Nairz M, Sirugo G, Bejon P, Kwiatkowski DP, Prentice AM, Atkinson SH
Wellcome Open Res, (2020). 5:40

Cost-effectiveness of oral versus intravenous antibiotics (OVIVA) in patients with bone and joint infection: evidence from a non-inferiority trial.McMeekin N, Geue C, Briggs A, Rombach I, Li HK, Bejon P, McNally M, Atkins BL, Ferguson J, Scarborough M, OVIVA collaborators
Wellcome Open Res, (2019). 4:108

Bayesian evaluation of the performance of three diagnostic tests for Plasmodium falciparum infection in a low-transmission setting in Kilifi County, Kenya.Mweu MM, Wambua J, Njuga F, Bejon P, Mwanga D
Wellcome Open Res, (2019). 4:67

Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort.Muthui MK, Mogeni P, Mwai K, Nyundo C, Macharia A, Williams TN, Nyangweso G, Wambua J, Mwanga D, Marsh K, Bejon P, Kapulu MC
Wellcome Open Res, (2019). 4:66

A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01 E on blood stage immunity in young Kenyan children.Ndungu FM, Mwacharo J, Wambua J, Njuguna P, Marsh K, Drakeley C, Bejon P
Wellcome Open Res, (2019). 4:42

Evolution of a programme to engage school students with health research and science in Kenya.Davies A, Mwangome N, Yeri B, Mwango G, Mumba N, Marsh V, Kamuya D, Molyneux S, Kinyanjui S, Jones C
Wellcome Open Res, (2019). 4:39

Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity.Kapulu MC, Njuguna P, Hamaluba MM, CHMI-SIKA Study Team
Wellcome Open Res, (2018). 3:155

Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres.Otto TD, Bohme U, Sanders M, Reid A, Bruske EI, Duffy CW, Bull PC, Pearson RD, Abdi A, Dimonte S, Stewart LB, Campino S, Kekre M, Hamilton WL, Claessens A, Volkman SK, Ndiaye D, Amambua-Ngwa A, Diakite M, Fairhurst RM, Conway DJ, Franck M, Newbold CI, Berriman M
Wellcome Open Res, (2018). 3:52

Ethical considerations in Controlled Human Malaria Infection studies in low resource settings: Experiences and perceptions of study participants in a malaria Challenge study in Kenya.Njue M, Njuguna P, Kapulu MC, Sanga G, Bejon P, Marsh V, Molyneux S, Kamuya D
Wellcome Open Res, (2018). 3:39

Variation in the effectiveness of insecticide treated nets against malaria and outdoor biting by vectors in Kilifi, Kenya.Kamau A, Mwangangi JM, Rono MK, Mogeni P, Omedo I, Midega J, Scott JAG, Bejon P
Wellcome Open Res, (2017). 2:22

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters.Ndung'u L, Langat B, Magiri E, Ng'ang'a J, Irungu B, Nzila A, Kiboi D
Wellcome Open Res, (2017). 2:44

Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children.Njunge JM, Oyaro IN, Kibinge NK, Rono MK, Kariuki SM, Newton CR, Berkley JA, Gitau EN
Wellcome Open Res, (2017). 2:47

A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi.Gordon SB, Rylance J, Luck A, Jambo K, Ferreira DM, Manda-Taylor L, Bejon P, Ngwira B, Littler K, Seager Z, Gibani M, Gmeiner M, Roestenberg M, Mlombe Y, Wellcome Trust CHIM workshop participants
Wellcome Open Res, (2017). 2:70

Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome.Abdi A, Yu L, Goulding D, Rono MK, Bejon P, Choudhary J, Rayner J
Wellcome Open Res, (2017). 2:50

Geographic-genetic analysis of Plasmodium falciparum parasite populations from surveys of primary school children in Western Kenya.Omedo I, Mogeni P, Rockett K, Kamau A, Hubbart C, Jeffreys A, Ochola-Oyier LI, de Villiers EP, Gitonga CW, Noor AM, Snow RW, Kwiatkowski D, Bejon P
Wellcome Open Res, (2017). 2:29