Epidemiology & Demography

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Prof. Tom Williams

Principal Investigator


Publications

Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial.
Power-Hays, A., Tomlinson, G. A., Tshilolo, L., Santos, B., Williams, T. N., Olupot-Olupot, P., Smart, L. R., Aygun, B., Lane, A., Stuber, S. E., Latham, T., Ware, R. E.
Am J Hematol, (2024). :

Dantu Blood Group Erythrocytes Form Large Plasmodium falciparum Rosettes Less Commonly.
Carlier, M. S. A., Nyamu, W., Makale, J., Williams, T. N., Rowe, J. A., Kariuki, S. N.
Am J Trop Med Hyg, (2024). 110:436-443

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.
Odera, D. O., Tuju, J., Mwai, K., Nkumama, I. N., Fürle, K., Chege, T., Kimathi, R., Diehl, S., Musasia, F. K., Rosenkranz, M., Njuguna, P., Hamaluba, M., Kapulu, M. C., Frank, R., Osier, F. H. A., Abdi, A. I., Chi, P. C., de Laurent, Z., Jao, I., Kamuya, D., Kamuyu, G., Makale, J., Murungi, L., Musyoki, J., Muthui, M., Mwacharo, J., Kariuki, S., Mwanga, D., Mwongeli, J., Ndungu, F., Njue, M., Nyangweso, G., Kimani, D., Ngoi, J. M., Musembi, J., Ngoto, O., Otieno, E., Ooko, M., Shangala, J., Wambua, J., Mohammed, K. S., Omuoyo, D., Mosobo, M., Kibinge, N., Kinyanjui, S., Bejon, P., Lowe, B., Marsh, K., Marsh, V., Abebe, Y., Billingsley, P. F., Sim, B. K. L., Hoffman, S. L., James, E. R., Richie, T. L., Audi, A., Olewe, F., Oloo, J., Ongecha, J., Ongas, M. O., Koskei, N., Bull, P. C., Hodgson, S. H., Kivisi, C., Imwong, M., Murphy, S. C., Ogutu, B., Tarning, J., Winterberg, M., Williams, T. N.
Sci Transl Med, (2023). 15:eabn5993

Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study.
Otiende, M., Nyaguara, A., Bottomley, C., Walumbe, D., Mochamah, G., Amadi, D., Nyundo, C., Kagucia, E. W., Etyang, A. O., Adetifa, I. M. O., Brand, S. P. C., Maitha, E., Chondo, E., Nzomo, E., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Ng'ang'a, W., Barasa, E., Tsofa, B., Mwangangi, J., Bejon, P., Agweyu, A., Williams, T. N., Scott, J. A. G.
Nat Commun, (2023). 14:6879

Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.
Onyamboko, M. A., Olupot-Olupot, P., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Okalebo, C. B., Williams, T. N., Uyoga, S., Taya, C., Bamisaiye, A., Fanello, C., Maitland, K., Day, N. P. J., Taylor, W. R. J., Mukaka, M.
BMC Med, (2023). 21:397

Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria.
Mukaka, M., Onyamboko, M. A., Olupot-Olupot, P., Peerawaranun, P., Suwannasin, K., Pagornrat, W., Kouhathong, J., Madmanee, W., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Bongo, G. S., Okalebo, C. B., Abongo, G., Uyoga, S., Williams, T. N., Taya, C., Dhorda, M., Dondorp, A. M., Waithira, N., Imwong, M., Maitland, K., Fanello, C., Day, N. P. J., Tarning, J., White, N. J., Taylor, W. R. J.
EBioMedicine, (2023). 96:104805

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.
Opi, D. H., Ndila, C. M., Uyoga, S., Macharia, A. W., Fennell, C., Ochola, L. B., Nyutu, G., Siddondo, B. R., Ojal, J., Shebe, M., Awuondo, K. O., Mturi, N., Peshu, N., Tsofa, B., Band, G., Maitland, K., Kwiatkowski, D. P., Rockett, K. A., Williams, T. N., Rowe, J. A.
PLoS Genet, (2023). 19:e1010910

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.
Olupot-Olupot, P., Okiror, W., Mnjalla, H., Muhindo, R., Uyoga, S., Mpoya, A., Williams, T. N., terHeine, R., Burger, D. M., Urban, B., Connon, R., George, E. C., Gibb, D. M., Walker, A. S., Maitland, K.
Wellcome Open Res, (2021). 6:161

The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study.
Kariuki, S. N., Macharia, A. W., Makale, J., Nyamu, W., Hoffman, S. L., Kapulu, M. C., Bejon, P., Rayner, J. C., Williams, T. N.
Elife, (2023). 12:e83874

Mortality in rural coastal Kenya measured using the Kilifi Health and Demographic Surveillance System: a 16-year descriptive analysis [version 2; peer review: 1 approved, 1 approved with reservations].
Otiende, M., Bauni, E., Nyaguara, A., Amadi, D., Nyundo, C., Tsory, E., Walumbe, D., Kinuthia, M., Kihuha, N., Kahindi, M., Nyutu, G., Moisi, J., Deribew, A., Agweyu, A., Marsh, K., Tsofa, B., Bejon, P., Bottomley, C., Williams, T. N., Scott, J. A. G.
Wellcome Open Research, (2023). 6: