Clinical Research

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Dr. Ally Olotu

Principal Investigator


Publications

Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023.
Kapulu, M., Manda-Taylor, L., Balasingam, S., Means, G., Ayiro Malungu, M., Bejon, P., Chi, P. C., Chiu, C., Church, E. C., Correa-Oliveira, R., Day, N., Durbin, A., Egesa, M., Emerson, C., Jambo, K., Mathur, R., Metzger, W., Mumba, N., Nazziwa, W., Olotu, A., Rodgers, J., Sinyiza, F., Talaat, K., Kamerling, I., Weller, C., Baay, M., Neels, P.
Biologicals, (2024). :101747

Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
Datoo, M. S., Dicko, A., Tinto, H., Ouédraogo, J. B., Hamaluba, M., Olotu, A., Beaumont, E., Ramos Lopez, F., Natama, H. M., Weston, S., Chemba, M., Compaore, Y. D., Issiaka, D., Salou, D., Some, A. M., Omenda, S., Lawrie, A., Bejon, P., Rao, H., Chandramohan, D., Roberts, R., Bharati, S., Stockdale, L., Gairola, S., Greenwood, B. M., Ewer, K. J., Bradley, J., Kulkarni, P. S., Shaligram, U., Hill, A. V. S.
Lancet, (2024). 403:533-544

Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023.
Cavaleri, M., Kaslow, D., Boateng, E., Chen, W. H., Chiu, C., Choy, R. K. M., Correa-Oliveira, R., Durbin, A., Egesa, M., Gibani, M., Kapulu, M., Katindi, M., Olotu, A., Pongsuwan, P., Simuyandi, M., Speder, B., Talaat, K. R., Weller, C., Wills, B., Baay, M., Balasingam, S., Olesen, O. F., Neels, P.
Biologicals, (2024). :101745

Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
Datoo, M. S., Dicko, A., Tinto, H., Ouédraogo, J. B., Hamaluba, M., Olotu, A., Beaumont, E., Ramos Lopez, F., Natama, H. M., Weston, S., Chemba, M., Compaore, Y. D., Issiaka, D., Salou, D., Some, A. M., Omenda, S., Lawrie, A., Bejon, P., Rao, H., Chandramohan, D., Roberts, R., Bharati, S., Stockdale, L., Gairola, S., Greenwood, B. M., Ewer, K. J., Bradley, J., Kulkarni, P. S., Shaligram, U., Hill, A. V. S.
Lancet, (2024). 403:533-544

Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria.
Richie, T. L., Church, L. W. P., Murshedkar, T., Billingsley, P. F., James, E. R., Chen, M. C., Abebe, Y., Natasha, Kc, Chakravarty, S., Dolberg, D., Healy, S. A., Diawara, H., Sissoko, M. S., Sagara, I., Cook, D. M., Epstein, J. E., Mordm�ller, B., Kapulu, M., Kreidenweiss, A., Franke-Fayard, B., Agnandji, S. T., L�pez Mikue, M. A., McCall, M. B. B., Steinhardt, L., Oneko, M., Olotu, A., Vaughan, A. M., Kublin, J. G., Murphy, S. C., Jongo, S., Tanner, M., Sirima, S. B., Laurens, M. B., Daubenberger, C., Silva, J. C., Lyke, K. E., Janse, C. J., Roestenberg, M., Sauerwein, R. W., Abdulla, S., Dicko, A., Kappe, S. H. I., Sim, B. K. L., Duffy, P. E., Kremsner, P. G., Hoffman, S. L.
Expert Rev Vaccines, (2023). 22:964-1007

Pre-vaccination monocyte-to-lymphocyte ratio as a biomarker for the efficacy of malaria candidate vaccines: A subgroup analysis of pooled clinical trial data.
Nyandele, J. P., Kibondo, U. A., Issa, F., Van Geertruyden, J. P., Warimwe, G., Jongo, S., Abdulla, S., Olotu, A.
PLoS One, (2023). 18:e0291244

The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea.
Manock, S. R., Nsue, V. U., Olotu, A., Mpina, M., Nyakarungu, E., Raso, J., Mtoro, A., Ondo Mangue, M. E., Ntutumu Pasialo, B. E., Nguema, R., Riyahi, P., Schindler, T., Daubenberger, C., Church, L. W. P., Billingsley, P. F., Richie, T. L., Abdulla, S., Hoffman, S. L.
Trans R Soc Trop Med Hyg, (2022). 116:745-749

Malaria hospitalisation in East Africa: age, phenotype and transmission intensity.
Kamau, A., Paton, R. S., Akech, S., Mpimbaza, A., Khazenzi, C., Ogero, M., Mumo, E., Alegana, V. A., Agweyu, A., Mturi, N., Mohammed, S., Bigogo, G., Audi, A., Kapisi, J., Sserwanga, A., Namuganga, J. F., Kariuki, S., Otieno, N. A., Nyawanda, B. O., Olotu, A., Salim, N., Athuman, T., Abdulla, S., Mohamed, A. F., Mtove, G., Reyburn, H., Gupta, S., Lourenco, J., Bejon, P., Snow, R. W.
BMC Med, (2022). 20:28

Providing Ancillary Care in Clinical Research: A Case of Diffuse Large B-Cell Lymphoma during a Malaria Vaccine Trial in Equatorial Guinea.
Manock, S. R., Mtoro, A., Urbano Nsue Ndong, V., Olotu, A., Chemba, M., Sama Roca, A. E., Eburi, E., Garcia, G. A., Cortes Falla, C., Niemczura de Carvalho, J., Contreras, J., Saturno, B., Riocalo, J. D., Nze Mba, J. L., Koka, R., Lee, S. T., Menon, H., Church, L. W. P., Ayekaba, M. O., Billingsley, P. F., Abdulla, S., Richie, T. L., Hoffman, S. L.
Am J Trop Med Hyg, (2020). 104:695-699

The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa.
Billingsley, P. F., Maas, C. D., Olotu, A., Schwabe, C., Garcia, G. A., Rivas, M. R., Hergott, D. E. B., Daubenberger, C., Saverino, E., Chaouch, A., Embon, O., Chemba, M., Nyakarungu, E., Hamad, A., Cortes, C., Schindler, T., Mpina, M., Mtoro, A., Sim, B. K. L., Richie, T. L., McGhee, K., Tanner, M., Obiang Lima, G. M., Abdulla, S., Hoffman, S. L., Ayekaba, M. O.
Am J Trop Med Hyg, (2020). 103:947-954