Clinical Research

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Prof Peter Olupot Olupot

Principal Investigator


Publications

Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial.
Power-Hays, A., Tomlinson, G. A., Tshilolo, L., Santos, B., Williams, T. N., Olupot-Olupot, P., Smart, L. R., Aygun, B., Lane, A., Stuber, S. E., Latham, T., Ware, R. E.
Am J Hematol, (2024). :

Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.
Onyamboko, M. A., Olupot-Olupot, P., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Okalebo, C. B., Williams, T. N., Uyoga, S., Taya, C., Bamisaiye, A., Fanello, C., Maitland, K., Day, N. P. J., Taylor, W. R. J., Mukaka, M.
BMC Med, (2023). 21:397

Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria.
Mukaka, M., Onyamboko, M. A., Olupot-Olupot, P., Peerawaranun, P., Suwannasin, K., Pagornrat, W., Kouhathong, J., Madmanee, W., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Bongo, G. S., Okalebo, C. B., Abongo, G., Uyoga, S., Williams, T. N., Taya, C., Dhorda, M., Dondorp, A. M., Waithira, N., Imwong, M., Maitland, K., Fanello, C., Day, N. P. J., Tarning, J., White, N. J., Taylor, W. R. J.
EBioMedicine, (2023). 96:104805

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.
Olupot-Olupot, P., Okiror, W., Mnjalla, H., Muhindo, R., Uyoga, S., Mpoya, A., Williams, T. N., terHeine, R., Burger, D. M., Urban, B., Connon, R., George, E. C., Gibb, D. M., Walker, A. S., Maitland, K.
Wellcome Open Res, (2021). 6:161

Cardiovascular abnormalities in chest radiographs of children with pneumonia, Uganda.
Nabawanuka, E., Ameda, F., Erem, G., Bugeza, S., Opoka, R. O., Kiguli, S., Amorut, D., Aloroker, F., Olupot-Olupot, P., Mnjalla, H., Mpoya, A., Maitland, K.
Bull World Health Organ, (2023). 101:202-210

Hydroxyurea is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.
Olupot-Olupot, P., Tomlinson, G., Williams, T. N., Tshilolo, L. M. M., Santos, B., Smart, L. R., McElhinney, K., Howard, T. A., Aygun, B., Stuber, S. E., Lane, A., Latham, T., Ware, R. E.
Blood, (2022). 141:1402-1410

Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial.
Taylor, W. R., Olupot-Olupot, P., Onyamboko, M. A., Peerawaranun, P., Weere, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Bongo, G. S., Okalebo, C. B., Abongo, G., Uyoga, S., Williams, T. N., Taya, C., Dhorda, M., Tarning, J., Dondorp, A. M., Waithira, N., Fanello, C., Maitland, K., Mukaka, M., Day, N. J. P.
Lancet Infect Dis, (2022). 23:471-483

High false discovery rate of the Architect anti-HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing.
Lucey, O., Acana, S., Olupot-Olupot, P., Muhindo, R., Ayikobua, R., Uyoga, S., Kyeyune-Byabazaire, D., Cooke, G., Maitland, K.
Vox Sang, (2022). 117:1360-1367

Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT).
Uyoga, S., Olupot-Olupot, P., Connon, R., Kiguli, S., Opoka, R. O., Alaroker, F., Muhindo, R., Macharia, A. W., Dondorp, A. M., Gibb, D. M., Walker, A. S., George, E. C., Maitland, K., Williams, T. N.
Lancet Child Adolesc Health, (2022). 6:606-613

A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era.
Obonyo, N. G., Olupot-Olupot, P., Mpoya, A., Nteziyaremye, J., Chebet, M., Uyoga, S., Muhindo, R., Fanning, J. P., Shiino, K., Chan, J., Fraser, J. F., Maitland, K.
Pediatr Crit Care Med, (2022). 23:502-513