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Biography
Jay is a consultant paediatrician and sub-specialist in paediatric infectious diseases and immunology based at the KEMRI Centre for Geographic Medicine Research Coast and Wellcome Trust Research Programme in Kilifi, Kenya. Jay is the Founder and co-Director of the Childhood Acute Illness & Nutrition (CHAIN) Network of partners in Africa (Kenya, Uganda, Malawi, Burkina Faso), South Asia (Pakistan, Bangladesh), UK, USA, Canada and The Netherlands. The CHAIN Network is headquartered in Nairobi, Kenya. The team aims to better understand infectious, immune, metabolic, nutritional, health systems and social pathways to childhood mortality to identify actionable interventions through an epidemiological cohort, systems biology analysis pipeline, social science platform and a multicentre clinical trials platform. Jay joined the KEMRI/Wellcome Trust Collaborative Research Programme in Kilifi, Kenya in 1997. He undertook a Wellcome Trust Research Training Fellowship on invasive bacterial infections and their relationships with malaria, HIV and malnutrition. After completing specialist training in paediatrics and sub-specialist training in paediatric clinical immunology and infectious diseases in the UK, Jay returned to Kilifi.
Current Work
The focus of his clinical research is serious infection and survival in vulnerable groups of young infants and children, teaching, training and mentorship. The research group addresses aetiology, clinical features and risks for mortality of serious infections in infants and children; mechanistic studies including microbiology, antimicrobial resistance, immunology, metabolomics and proteomics; and clinical trials, including early pharmacokinetics and safety trials, and large international multicentre phase III trials on antimicrobial and nutritional interventions in vulnerable paediatric populations. Jay is involved in the Kenyan national training programme on integrated management of severe acute malnutrition and is an expert adviser to the Ministries of Health and the World Health Organisation.Collaborations
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Publications
The double burden of malnutrition in individuals: Identifying key challenges and re-thinking research focus.
Kiosia, A., Dagbasi, A., Berkley, J. A., Wilding, J. P. H., Prendergast, A. J., Li, J. V., Swann, J., Mathers, J. C., Kerac, M., Morrison, D., Drake, L., Briend, A., Maitland, K., Frost, G.
Nutr Bull, (2024). :
Childhood growth during recovery from acute illness in Africa and South Asia: a secondary analysis of the childhood acute illness and nutrition (CHAIN) prospective cohort.
Bourdon, C., Diallo, A. H., Mohammad Sayeem Bin Shahid, A. S., Khan, M. A., Saleem, A. F., Singa, B. O., Gnoumou, B. S., Tigoi, C., Otieno, C. A., Oduol, C. O., Lancioni, C. L., Manyasi, C., McGrath, C. J., Maronga, C., Lwanga, C., Brals, D., Ahmed, D., Mondal, D., Denno, D. M., Mangale, D. I., Chimwezi, E., Mbale, E., Mupere, E., Salauddin Mamun, G. M., Ouédraogo, I., Berkley, J. A., Njunge, J. M., Njirammadzi, J., Mukisa, J., Thitiri, J., Walson, J. L., Jemutai, J., Tickell, K. D., Shahrin, L., Mallewa, M., Hossain, M. I., Chisti, M. J., Timbwa, M., Mburu, M., Ngari, M. M., Ngao, N., Aber, P., Harawa, P. P., Sukhtankar, P., Bandsma, R. H. J., Bamouni, R. M., Molyneux, S., Mwaringa, S., Shaima, S. N., Ali, S. A., Afsana, S. M., Banu, S., Ahmed, T., Voskuijl, W. P., Kazi, Z.
EClinicalMedicine, (2024). 70:102530
Vaccine value profile for Klebsiella pneumoniae.
Dangor, Z., Benson, N., Berkley, J. A., Bielicki, J., Bijsma, M. W., Broad, J., Buurman, E. T., Cross, A., Duffy, E. M., Holt, K. E., Iroh Tam, P. Y., Jit, M., Karampatsas, K., Katwere, M., Kwatra, G., Laxminarayan, R., Le Doare, K., Mboizi, R., Micoli, F., Moore, C. E., Nakabembe, E., Naylor, N. R., O'Brien, S., Olwagen, C., Reddy, D., Rodrigues, C., Rosen, D. A., Sadarangani, M., Srikantiah, P., Tennant, S. M., Hasso-Agopsowicz, M., Madhi, S. A.
Vaccine, (2024). :
Prevalence and correlates of paediatric guideline non-adherence for initial empirical care in six low and middle-income settings: a hospital-based cross-sectional study.
Shawon, R. A., Denno, D., Tickell, K. D., Atuhairwe, M., Bandsma, R., Mupere, E., Voskuijl, W., Mbale, E., Ahmed, T., Chisti, M. J., Saleem, A. F., Ngari, M., Diallo, A. H., Berkley, J., Walson, J., Means, A. R.
BMJ Open, (2024). 14:e078404
Stunting in the first year of life: Pathway analysis of a birth cohort.
Mwangome, M., Ngari, M., Brals, D., Bawhere, P., Kabore, P., McGrath, M., Berkley, J. A.
PLOS Glob Public Health, (2024). 4:e0002908
Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study.
Afroze, F., Khoshnevisan, F., Harawa, P. P., Islam, Z., Bourdon, C., Khoswe, S., Islam, M., Sarker, S. A., Islam, F., Sayeem Bin Shahid, A. S. M., Joosten, K., Hulst, J. M., Eneya, C., Walson, J. L., Berkley, J. A., Potani, I., Voskuijl, W., Ahmed, T., Chisti, M. J., Bandsma, R. H. J.
Sci Rep, (2024). 14:3613
A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism.
Thind, M. K., Uhlig, H. H., Glogauer, M., Palaniyar, N., Bourdon, C., Gwela, A., Lancioni, C. L., Berkley, J. A., Bandsma, R. H. J., Farooqui, A.
Front Immunol, (2023). 14:1334205
Evaluating blood culture collection practice in children hospitalized with acute illness at a tertiary hospital in Malawi.
Mukhula, V. T., Harawa, P. P., Phiri, C., Khoswe, S., Mbale, E., Tigoi, C., Walson, J. L., Berkley, J. A., Bandsma, R., Iroh Tam, P. Y., Voskuijl, W.
J Trop Pediatr, (2023). 70:fmad043
New approaches and technical considerations in detecting outlier measurements and trajectories in longitudinal children growth data.
Massara, P., Asrar, A., Bourdon, C., Ngari, M., Keown-Stoneman, C. D. G., Maguire, J. L., Birken, C. S., Berkley, J. A., Bandsma, R. H. J., Comelli, E. M.
BMC Med Res Methodol, (2023). 23:232
Intestinal disturbances associated with mortality of children with complicated severe malnutrition.
Wen, B., Farooqui, A., Bourdon, C., Tarafdar, N., Ngari, M., Chimwezi, E., Thitiri, J., Mwalekwa, L., Walson, J. L., Voskuijl, W., Berkley, J. A., Bandsma, R. H. J.
Commun Med (Lond), (2023). 3:128