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Biography
Kath Maitland's research excellence spans the entire translational cycle; from the bench through to clinical investigation and ultimately change in clinical practice and healthcare policy. In the challenging environment of the rural hospital emergency rooms in Africa, her team has conducted high-quality physiological studies and clinical trials generating the essential evidence base for patient management and informing both national and international policy. She has led large multicentre trials examining key supportive treatments for critically sick children including the ground-breaking fluid resuscitation (FEAST) and transfusion (TRACT) trials both bring new high-quality evidence leading to refinements of the guidelines. The childrens oxygen strategy trial (COAST) brought new understanding in oxygen therapy and non-invasive ventilation strategies. She is a Professor of Paediatric Tropical Infectious Diseases at the Faculty of Medicine and Director of the ICCARE Centre at the Global Centre of Health Innovation, Imperial College, London and an Honorary Fellow at MRC Clinical Trials Unit, University College, London.
Current Work
Currently I am leading a Wellcome funded Severe Malaria Africa – A consortium for Research and Trials (SMAART) consortium which is a multi-disciplinary team whose membership includes world leaders in severe malaria and experts in clinical trials with track records of successful high quality and collaborative research programmes across the continent. The overarching aim of SMAART is to improve outcomes from severe malaria in African children (since one in ten hospitalised with severe malaria continue to die by conducting better research studies faster. In severe malnutrition (SAM) we have ‘deconstructed’ key physiological elements’ provided definitive evidence to show that myocardial function in children with SAM is not aberrant and investigated fluid management, specifically in children with dehydrating diarrhoea. I am part of a large collaboration (https://www.imperial.ac.uk/hunger-project/) which have provided multiple lines of evidence indicating that there are several domains of gut function are aberrant. Our ultimate aim is to investigate whether a locally-manufactured feed incorporating legumes as a lactose-free, fermentable carbohydrate-containing alternatives, aimed at supporting global gut function compared to traditional milk-based SAM formulae, can reduce mortality. Fermentable carbohydrates provide a rich source of long chain fatty acids which improve the composition of normal gut microbes and positively influence immunological and metabolic function of the gut.Collaborations
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Publications
The double burden of malnutrition in individuals: Identifying key challenges and re-thinking research focus.
Kiosia, A., Dagbasi, A., Berkley, J. A., Wilding, J. P. H., Prendergast, A. J., Li, J. V., Swann, J., Mathers, J. C., Kerac, M., Morrison, D., Drake, L., Briend, A., Maitland, K., Frost, G.
Nutr Bull, (2024). :
Mortality among non-severely under nourished children with pneumonia globally: protocol for a systematic review and meta-analysis.
Nalwanga, D., Bakker, C., Kiggwe, A., Negash, A. A., Ocan, M., Briend, A., Maitland, K., Musiiime, V., Karamagi, C.
Wellcome Open Res, (2023). 8:551
Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis.
Obonyo, N. G., Sela, D. P., Raman, S., Rachakonda, R., Schneider, B., Hoe, L. E. S., Fanning, J. P., Bassi, G. L., Maitland, K., Suen, J. Y., Fraser, J. F.
Syst Rev, (2023). 12:221
Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.
Onyamboko, M. A., Olupot-Olupot, P., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Okalebo, C. B., Williams, T. N., Uyoga, S., Taya, C., Bamisaiye, A., Fanello, C., Maitland, K., Day, N. P. J., Taylor, W. R. J., Mukaka, M.
BMC Med, (2023). 21:397
Avoid re-interpreting fluid bolus recommendations for low-income settings.
Kiguli, S., Maitland, K., George, E.
Lancet Child Adolesc Health, (2023). 7:e18
Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria.
Mukaka, M., Onyamboko, M. A., Olupot-Olupot, P., Peerawaranun, P., Suwannasin, K., Pagornrat, W., Kouhathong, J., Madmanee, W., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Bongo, G. S., Okalebo, C. B., Abongo, G., Uyoga, S., Williams, T. N., Taya, C., Dhorda, M., Dondorp, A. M., Waithira, N., Imwong, M., Maitland, K., Fanello, C., Day, N. P. J., Tarning, J., White, N. J., Taylor, W. R. J.
EBioMedicine, (2023). 96:104805
Evaluation of Acceptability, Functionality, and Validity of a Passive Image-Based Dietary Intake Assessment Method in Adults and Children of Ghanaian and Kenyan Origin Living in London, UK.
Jobarteh, M. L., McCrory, M. A., Lo, B., Triantafyllidis, K. K., Qiu, J., Griffin, J. P., Sazonov, E., Sun, M., Jia, W., Baranowski, T., Anderson, A. K., Maitland, K., Frost, G.
Nutrients, (2023). 15:
Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.
Opi, D. H., Ndila, C. M., Uyoga, S., Macharia, A. W., Fennell, C., Ochola, L. B., Nyutu, G., Siddondo, B. R., Ojal, J., Shebe, M., Awuondo, K. O., Mturi, N., Peshu, N., Tsofa, B., Band, G., Maitland, K., Kwiatkowski, D. P., Rockett, K. A., Williams, T. N., Rowe, J. A.
PLoS Genet, (2023). 19:e1010910
Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.
Olupot-Olupot, P., Okiror, W., Mnjalla, H., Muhindo, R., Uyoga, S., Mpoya, A., Williams, T. N., terHeine, R., Burger, D. M., Urban, B., Connon, R., George, E. C., Gibb, D. M., Walker, A. S., Maitland, K.
Wellcome Open Res, (2021). 6:161
Blood transfusion for children in sub-Saharan Africa: 200 years on.
Uyoga, S., Mbanya, D., George, E. C., Maitland, K.
Lancet Child Adolesc Health, (2023). S2352-4642:00143-8