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Biography
Peter is a qualified and practicing medical doctor, clinical scientist and Professor. He holds MB.ChB, MPH and PhD. He is a Senior Research Fellow with EDCTP and a Fellow of Uganda National Academy of Sciences (FUNAS). His experience spans 25 years of highly productive clinical and academic career. He is a Professor at Busitema University and a founding Executive Director of a progressive Mbale Clinical Research Institute [MCRI, http://www.mcri.ac.ug] in Eastern Uganda. In addition, he is a Visiting Professor at The Open University in UK, and Clinical Adjunct Professor at the University of Wisconsin-Madison, USA. He is ranked among the top 25 out of 500 researchers in Uganda (https://mulengeranews.com/wp-content/uploads/2022/05/uganda-top-scientists-Edited.pdf).
Current Work
He has held grants as either PI or co-investigator investigating major public health conditions in Eastern Uganda including the Joint Global Health Trials (UK MRC, DFID, Wellcome) funded pneumonia trial (COAST, ISRCTN15622505), MRC funded PKPD of azithromycin in severe malaria bacterial co-infection in African children (TABS- PKPD, ISRCTN49726849), nutritional study (MIMBLE, ISRCTN 10309022), NIH funded sickle cell trial (REACH, NCT01966731), malaria studies (MEPIE Study, TMA2016SF1514), and Uganda Government funded COVID-19 studies. He has co-authored in over 130 publications of which 89 are indexed in PUBMED including 5 in the New England Journal of Medicine; [https://www.ncbi.nlm.nih.gov/pubmed/?term=Olupot-Olupot]. His current focus is on emerging and re-emerging infectious diseases on which he has furthered work on malaria research including severe malaria spectrum, malaria related acute kidney injury, COVID-19, Ebola virus disease among others. In addition, he does epidemiological research on haematological disorders and their co-morbidities.Collaborations
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Project Research
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Publications
Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial.
Power-Hays, A., Tomlinson, G. A., Tshilolo, L., Santos, B., Williams, T. N., Olupot-Olupot, P., Smart, L. R., Aygun, B., Lane, A., Stuber, S. E., Latham, T., Ware, R. E.
Am J Hematol, (2024). :
Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.
Onyamboko, M. A., Olupot-Olupot, P., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Okalebo, C. B., Williams, T. N., Uyoga, S., Taya, C., Bamisaiye, A., Fanello, C., Maitland, K., Day, N. P. J., Taylor, W. R. J., Mukaka, M.
BMC Med, (2023). 21:397
Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria.
Mukaka, M., Onyamboko, M. A., Olupot-Olupot, P., Peerawaranun, P., Suwannasin, K., Pagornrat, W., Kouhathong, J., Madmanee, W., Were, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Bongo, G. S., Okalebo, C. B., Abongo, G., Uyoga, S., Williams, T. N., Taya, C., Dhorda, M., Dondorp, A. M., Waithira, N., Imwong, M., Maitland, K., Fanello, C., Day, N. P. J., Tarning, J., White, N. J., Taylor, W. R. J.
EBioMedicine, (2023). 96:104805
Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.
Olupot-Olupot, P., Okiror, W., Mnjalla, H., Muhindo, R., Uyoga, S., Mpoya, A., Williams, T. N., terHeine, R., Burger, D. M., Urban, B., Connon, R., George, E. C., Gibb, D. M., Walker, A. S., Maitland, K.
Wellcome Open Res, (2021). 6:161
Cardiovascular abnormalities in chest radiographs of children with pneumonia, Uganda.
Nabawanuka, E., Ameda, F., Erem, G., Bugeza, S., Opoka, R. O., Kiguli, S., Amorut, D., Aloroker, F., Olupot-Olupot, P., Mnjalla, H., Mpoya, A., Maitland, K.
Bull World Health Organ, (2023). 101:202-210
Hydroxyurea is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.
Olupot-Olupot, P., Tomlinson, G., Williams, T. N., Tshilolo, L. M. M., Santos, B., Smart, L. R., McElhinney, K., Howard, T. A., Aygun, B., Stuber, S. E., Lane, A., Latham, T., Ware, R. E.
Blood, (2022). 141:1402-1410
Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial.
Taylor, W. R., Olupot-Olupot, P., Onyamboko, M. A., Peerawaranun, P., Weere, W., Namayanja, C., Onyas, P., Titin, H., Baseke, J., Muhindo, R., Kayembe, D. K., Ndjowo, P. O., Basara, B. B., Bongo, G. S., Okalebo, C. B., Abongo, G., Uyoga, S., Williams, T. N., Taya, C., Dhorda, M., Tarning, J., Dondorp, A. M., Waithira, N., Fanello, C., Maitland, K., Mukaka, M., Day, N. J. P.
Lancet Infect Dis, (2022). 23:471-483
High false discovery rate of the Architect anti-HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing.
Lucey, O., Acana, S., Olupot-Olupot, P., Muhindo, R., Ayikobua, R., Uyoga, S., Kyeyune-Byabazaire, D., Cooke, G., Maitland, K.
Vox Sang, (2022). 117:1360-1367
Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT).
Uyoga, S., Olupot-Olupot, P., Connon, R., Kiguli, S., Opoka, R. O., Alaroker, F., Muhindo, R., Macharia, A. W., Dondorp, A. M., Gibb, D. M., Walker, A. S., George, E. C., Maitland, K., Williams, T. N.
Lancet Child Adolesc Health, (2022). 6:606-613
A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era.
Obonyo, N. G., Olupot-Olupot, P., Mpoya, A., Nteziyaremye, J., Chebet, M., Uyoga, S., Muhindo, R., Fanning, J. P., Shiino, K., Chan, J., Fraser, J. F., Maitland, K.
Pediatr Crit Care Med, (2022). 23:502-513