Clinical Research

Bio

Charles was born in Kenya, qualified in Cape Town, South Africa, with postgraduate training in Paediatrics in Manchester and London, United Kingdom. As a lecturer at University of Oxford, he returned to Kilifi Kenya in 1989, to help set up an unit to study severe malaria in African children. Thereafter he spent 2 years as a Post-doctoral fellow at Johns Hopkins, USA; studying mechanisms of brain damage in central nervous system infections. He completed his training in Paediatric Neurology at Great Ormond Street Hospital, UK. In 1998 he was awarded a Wellcome Trust Senior Clinical Fellowship at University College London, to return to Kilifi, to study CNS infections in children. He has published on a wide variety of subjects concerning sick children in tropical countries. In 2011 he took up a professorship in Psychiatry at the University of Oxford to concentrate of neurological and mental illness disorders in children living in Africa.

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Current Work

He conducts research on CNS infections in children; epidemiological studies of epilepsy and neurological impairment; tetanus, jaundice and sepsis in neonates. At present he is conducting studies of Autism and Epilepsy in Africa and working on sickle cell disease in Tanzania.

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Recent publications

The impact of COVID-19 on people with epilepsy: Global results from the coronavirus and epilepsy study.
Vasey, M. J., Tai, X. Y., Thorpe, J., Jones, G. D., Ashby, S., Hallab, A., Ding, D., Andraus, M., Dugan, P., Perucca, P., Costello, D. J., French, J. A., O'Brien, T. J., Depondt, C., Andrade, D. M., Sengupta, R., Datta, A., Delanty, N., Jette, N., Newton, C. R., Brodie, M. J., Devinsky, O., Cross, J. H., Sander, J. W., Hanna, J., Besag, F. M. C., Sen, A.
Epilepsia Open, (2024). :

Prevalence of onchocerciasis and epilepsy in a Tanzanian region after a prolonged community-directed treatment with ivermectin.
Mushi, V. P., Bhwana, D., Massawe, I. S., Makunde, W., Sebukoto, H., Ngasa, W., Sengerema, J., Mhina, A., Hayuma, P. M., Kimambo, H., Kidima, W., Matuja, W., Sander, J. W., Cross, H., Sen, A., Colebunders, R., Newton, C. R., Mmbando, B. P.
PLoS Negl Trop Dis, (2024). 18:e0012470

Evaluation of the psychometric properties of the UBACC questionnaire in a multi-country psychiatric study in Africa.
Kipkemoi, P., Mufford, M. S., Akena, D., Alemayehu, M., Atwoli, L., Chibnik, L. B., Gelaye, B., Gichuru, S., Kariuki, S. M., Koenen, K. C., Kwobah, E., Kyebuzibwa, J., Mwema, R. M., Newton, C. R. J. C., Pretorius, A., Stein, D. J., Stevenson, A., Stroud, R. E., 2nd, Teferra, S., Zingela, Z., Post, K., Korte, K. J.
Compr Psychiatry, (2024). 135:152526

The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria.
Kioko, M., Mwangi, S., Pance, A., Ochola-Oyier, L. I., Kariuki, S., Newton, C., Bejon, P., Rayner, J. C., Abdi, A. I.
Sci Adv, (2024). 10:eadl2256

Brushing away barriers: The healing touch of art as an intervention in children with autism.
Gulati, S., Kamila, G., Hameed, B., Newton, C. R. J. C.
Autism, (2024). :1.36236132412748E+016