Bioscience

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Dr Abdirahman Abdi

Principal Investigator


Publications

Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected.
Kimenyi, K. M., Akinyi, M. Y., Mwikali, K., Gilmore, T., Mwangi, S., Omer, E., Gichuki, B., Wambua, J., Njunge, J., Obiero, G., Bejon, P., Langhorne, J., Abdi, A., Ochola-Oyier, L. I.
BMC Infect Dis, (2024). 24:140

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.
Odera, D. O., Tuju, J., Mwai, K., Nkumama, I. N., Fürle, K., Chege, T., Kimathi, R., Diehl, S., Musasia, F. K., Rosenkranz, M., Njuguna, P., Hamaluba, M., Kapulu, M. C., Frank, R., Osier, F. H. A., Abdi, A. I., Chi, P. C., de Laurent, Z., Jao, I., Kamuya, D., Kamuyu, G., Makale, J., Murungi, L., Musyoki, J., Muthui, M., Mwacharo, J., Kariuki, S., Mwanga, D., Mwongeli, J., Ndungu, F., Njue, M., Nyangweso, G., Kimani, D., Ngoi, J. M., Musembi, J., Ngoto, O., Otieno, E., Ooko, M., Shangala, J., Wambua, J., Mohammed, K. S., Omuoyo, D., Mosobo, M., Kibinge, N., Kinyanjui, S., Bejon, P., Lowe, B., Marsh, K., Marsh, V., Abebe, Y., Billingsley, P. F., Sim, B. K. L., Hoffman, S. L., James, E. R., Richie, T. L., Audi, A., Olewe, F., Oloo, J., Ongecha, J., Ongas, M. O., Koskei, N., Bull, P. C., Hodgson, S. H., Kivisi, C., Imwong, M., Murphy, S. C., Ogutu, B., Tarning, J., Winterberg, M., Williams, T. N.
Sci Transl Med, (2023). 15:eabn5993

Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum.
Kioko, M., Pance, A., Mwangi, S., Goulding, D., Kemp, A., Rono, M., Ochola-Oyier, L. I., Bull, P. C., Bejon, P., Rayner, J. C., Abdi, A. I.
Nature Communications, (2023). 14:6447

From contigs towards chromosomes: automatic improvement of long read assemblies (ILRA).
Ruiz, J. L., Reimering, S., Escobar-Prieto, J. D., Brancucci, N. M. B., Echeverry, D. F., Abdi, A. I., Marti, M., Gómez-Díaz, E., Otto, T. D.
Brief Bioinform, (2023). 24:bbad248

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment.
Abdi, A. I., Achcar, F., Sollelis, L., Silva-Filho, J. L., Mwikali, K., Muthui, M., Mwangi, S., Kimingi, H. W., Orindi, B., Andisi, C., Alkema, M., Chandrasekar, A., Bull, P. C., Bejon, P., Modrzynska, K., Bousema, T., Marti, M.
Elife, (2023). 12:e85140

Analysis of var Gene Transcription Pattern Using DBLalpha Tags.
Andisi, K. C., Abdi, A. I.
Methods Mol Biol, (2022). 2470:173-184

Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study.
Kimingi, H. W., Kinyua, A. W., Achieng, N. A., Wambui, K. M., Mwangi, S., Nguti, R., Kivisi, C. A., Jensen, A. T. R., Bejon, P., Kapulu, M. C., Abdi, A. I., Kinyanjui, S. M., CHMI-SIKA Study Team
Front Immunol, (2022). 13:894770

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018.
Kimenyi, K. M., Wamae, K., Ngoi, J. M., de Laurent, Z. R., Ndwiga, L., Osoti, V., Obiero, G., Abdi, A. I., Bejon, P., Ochola-Oyier, L. I.
Malar J, (2022). 21:192

Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition.
Maghraby, M. K., Li, B., Chi, L., Ling, C., Benmoussa, A., Provost, P., Postmus, A. C., Abdi, A., Pierro, A., Bourdon, C., Bandsma, R. H. J.
Sci Rep, (2021). 11:7635

Exploring Plasmodium falciparum Var Gene Expression to Assess Host Selection Pressure on Parasites During Infancy.
Kivisi, C. A., Muthui, M., Hunt, M., Fegan, G., Otto, T. D., Githinji, G., Warimwe, G. M., Rance, R., Marsh, K., Bull, P. C., Abdi, A. I.
Front Immunol, (2019). 10:2328