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Biography
Upon completion of her PhD training, Euniece was awarded a Wellcome Training Fellowship to determine whether exposure to HIV antigens or to an altered cytokine environment in utero alters the developing immune responses in HIV-exposed but uninfected infants. In parallel determined immune responses to childhood vaccines in HIV infected children. In 2017, she was awarded a four-years mid-career research fellowship through the Initiative to develop African Research Leaders (IDEAL) - DELTAS programme. This fellowship supported my work to understand cellular and molecular mechanisms involved in the generation of antibodies with relevant functions in HIV infection. During this time, I established collaboration with the International AIDS vaccine Initiative (IAVI) which is currently supporting my programme of work to characterize B cell responses and monoclonal antibodies to inform HIV vaccine design
Current Work
We are specifically interested in understanding differences in population immune baselines by characterizing the naïve B cell repertoire and HIV-antigen specific precursors in African populations. In addition, establishing immunogenicity testing frameworks for HIV vaccine studies. We are currently preparing for B cell and monoclonal antibody characterization for the G003 Clinical Trial that aims to use a germline targeting approach to elicit desired VRC01 class of antibodies. In addition, we are supporting immunogenicity testing (IFNg ELISPOTs) for the GREAT clinical trial (conserved Mosaic HIV-1 phase 1 Trial). As part of our research capacity strengthening agenda, I am actively involved in student supervision (interns, MSc students and Ph.D. students), mentorship and teaching immunology courses. Under the SANTHE consortium, on which I am a co-applicant, we recently received funding from the DELTAS-AESA programme and BMGF to support capacity building in the next four years. Appointments: Adjunct lecturer at Pwani University, Kilifi; member of the SANTHE Consortium Steering Committee. On-going collaborations: Dr. Daniel Muema - Kenya AIDS Vaccine Initiative – Institute of Clinical research (KAVI-ICR), Prof. Thumbi Ndungu - University of Kwa Zulu Natal – Africa Health Research Institute, Dr. Devin Sok/Elise Landais - Scripps Research Institute – Neutralizing Antibody Centre, Prof. Penny Moore - National Institute for Communicable Diseases (NICD), South Africa.Collaborations
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Project Research
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Publications
Exposure to common infections may shape basal immunity and potentially HIV-1 acquisition amongst a high-risk population in Coastal Kenya.
Fwambah, L., Andisi, C., Streatfield, C., Bromell, R., Hare, J., Esbjornsson, J., Ndung'u, T., Sanders, E. J., Hassan, A. S., Nduati, E.
Front Immunol, (2023). 14:1283559
Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro.
Nyagwange, J., Kutima, B., Mwai, K., Karanja, H. K., Gitonga, J. N., Mugo, D., Sein, Y., Wright, D., Omuoyo, D. O., Nyiro, J. U., Tuju, J., Nokes, D. J., Agweyu, A., Bejon, P., Ochola-Oyier, L. I., Scott, J. A. G., Lambe, T., Nduati, E., Agoti, C., Warimwe, G. M.
Int J Infect Dis, (2022). 127:11-16
Assessment of a diverse panel of transmitted/founder HIV-1 infectious molecular clones in a luciferase based CD8 T-cell mediated viral inhibition assay.
Fernandez, N., Hayes, P., Makinde, J., Hare, J., King, D., Xu, R., Rehawi, O., Mezzell, A. T., Kato, L., Mugaba, S., Serwanga, J., Chemweno, J., Nduati, E., Price, M. A., Osier, F., Ochsenbauer, C., Yue, L., Hunter, E., Gilmour, J.
Front Immunol, (2022). 13:1029029
A Novel Sample Selection Approach to Aid the Identification of Factors That Correlate With the Control of HIV-1 Infection.
Makinde, J., Nduati, E. W., Freni-Sterrantino, A., Streatfield, C., Kibirige, C., Dalel, J., Black, S. L., Hayes, P., Macharia, G., Hare, J., McGowan, E., Abel, B., King, D., Joseph, S., Iavi Protocol C Investigators., Hunter, E., Sanders, E. J., Price, M., Gilmour, J.
Front Immunol, (2021). 12:634832
Coordinated Fc-effector and neutralization functions in HIV-infected children define a window of opportunity for HIV vaccination.
Nduati, E. W., Gorman, M. J., Sein, Y., Hermanus, T., Yuan, D., Oyaro, I., Muema, D. M., Ndung'u, T., Alter, G., Moore, P. L.
AIDS, (2021). 35:1895-1905
Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans.
Sutton, H. J., Aye, R., Idris, A. H., Vistein, R., Nduati, E., Kai, O., Mwacharo, J., Li, X., Gao, X., Andrews, T. D., Koutsakos, M., Nguyen, T. H. O., Nekrasov, M., Milburn, P., Eltahla, A., Berry, A. A., Kc, N., Chakravarty, S., Sim, B. K. L., Wheatley, A. K., Kent, S. J., Hoffman, S. L., Lyke, K. E., Bejon, P., Luciani, F., Kedzierska, K., Seder, R. A., Ndungu, F. M., Cockburn, I. A.
Cell Rep, (2021). 34:108684
Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype.
Aye, R., Sutton, H. J., Nduati, E. W., Kai, O., Mwacharo, J., Musyoki, J., Otieno, E., Wambua, J., Bejon, P., Cockburn, I. A., Ndungu, F. M.
Eur J Immunol, (2020). 50:1187-1194
Symptom-based Scoring for Acute Human Immunodeficiency Virus.
Sanders, E. J., Kigoro, A., Thiong'o, A., Nduati, E., Graham, S. M.
Clin Infect Dis, (2019). 69:736-737
Peripheral blood mononuclear cell transcriptomes reveal an over-representation of down-regulated genes associated with immunity in HIV-exposed uninfected infants.
Musimbi, Z. D., Rono, M. K., Otieno, J. R., Kibinge, N., Ochola-Oyier, L. I., de Villiers, E. P., Nduati, E. W.
Sci Rep, (2019). 9:18124
Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants.
Garcia-Knight, M. A., Nduati, E., Hassan, A. S., Nkumama, I., Etyang, T. J., Hajj, N. J., Gambo, F., Odera, D., Berkley, J. A., Rowland-Jones, S. L., Urban, B.
AIDS, (2017). 31:1809-1818