clinical research areas
Critical care
We lead international consortia on: critical care of “the sick child” including trials of blood transfusion and fluid resuscitation, oxygen therapy and treatment of severe
Malnutrition
management of malnutrition including supportive care, nutritional rehabilitation and clinical/omic and pathophysiological pathway characterization; this work
Sickle cell
Treatment for sickle cell disease (now 1% of children in East Africa and a growing clinical burden) including trials of hydroxyurea and prophylactic
Antibiotic case management
The work involves trials of antibiotic stewardship.
 
Mental health
problems in LMIC settings are common in childhood, adolescence and adulthood and a major challenge to “the developing
Vaccines
Vaccine Programme Design and Evaluation
Human Infection Studies
Understanding naturally acquired immunity for the design, development and testing of vaccines.
Malaria vaccine development
Interrogating immunity (vaccine-induced and naturally acquired) to malaria
Pneumonia
Vaccine efficacy and treatment of pneumonia.
Rift Valley Fever
Developement of the ChAdOx1 RVF, chimpanzee adenovirus vectored Rift Valley Fever vaccine