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Dr. Mainga Hamaluba 9
Head Of Clinical Research
Biography
Mainga Hamaluba MBChB MD FRCPCH Head of Clinical Research. Mainga is a paediatrician and works on clinical trials of vaccines, human infections studies and neonatal care. She is Principal Investigator (PI) and lead of the R21 clinical development programme in Kenya which includes the first evaluation of R21 in Africa (Phase 1b and the ongoing phase 3 trials). This is complemented by a vaccine efficacy Human Infection Study where she is Co-PI. Furthermore, she is PI for a phase 1/2 (First-In-Human and phase 2 trial of the leading tetravalent candidate shigella vaccine); sponsored by LimmaTech Biologics Ag. She also has clinical oversight of the broad portfolio of KWTRP team Human Infection Study platforms for malaria and shigella. These complementary programs continue to accelerate the clinical development of malaria and shigella vaccines.
Biography
Mainga Hamaluba MBChB MD FRCPCH Head of Clinical Research. Mainga is a paediatrician and works on clinical trials of vaccines, human infections studies and neonatal care. She is Principal Investigator (PI) and lead of the R21 clinical development programme in Kenya which includes the first evaluation of R21 in Africa (Phase 1b and the ongoing phase 3 trials). This is complemented by a vaccine efficacy Human Infection Study where she is Co-PI. Furthermore, she is PI for a phase 1/2 (First-In-Human and phase 2 trial of the leading tetravalent candidate shigella vaccine); sponsored by LimmaTech Biologics Ag. She also has clinical oversight of the broad portfolio of KWTRP team Human Infection Study platforms for malaria and shigella. These complementary programs continue to accelerate the clinical development of malaria and shigella vaccines.
Current Work
Collaborations
Project Research
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Videos
Publications
Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge.
Nkumama, I. N., Ogwang, R., Odera, D., Musasia, F., Mwai, K., Nyamako, L., Murungi, L., Tuju, J., Fürle, K., Rosenkranz, M., Kimathi, R., Njuguna, P., Hamaluba, M., Kapulu, M. C., Frank, R., Osier, F. H. A.
Immunity, (2024). :
Nutritional supplementation in children with severe pneumonia in Uganda and Kenya (COAST-Nutrition): a phase 2 randomised controlled trial.
Kiguli, S., Olupot-Olupot, P., Hamaluba, M., Giallongo, E., Thomas, K., Alaroker, F., Opoka, R. O., Tagoola, A., Oyella, S., Nalwanga, D., Nabawanuka, E., Okiror, W., Nakuya, M., Amorut, D., Muhindo, R., Mpoya, A., Mnjalla, H., Oguda, E., Williams, T. N., Harrison, D. A., Rowan, K., Briend, A., Maitland, K.
EClinicalMedicine, (2024). 72:102640
Safety and immunogenicity of varied doses of R21/Matrix-Mâ„¢ vaccine at three years follow-up: A phase 1b age de-escalation, dose-escalation trial in adults, children, and infants in Kilifi-Kenya.
Sang, S., Datoo, M. S., Otieno, E., Muiruri, C., Bellamy, D., Gathuri, E., Ngoto, O., Musembi, J., Provstgaard-Morys, S., Stockdale, L., Aboagye, J., Woods, D., Lawrie, A., Roberts, R., Keter, K., Kimani, D., Ndungu, F., Kapulu, M., Njau, I., Orindi, B., Ewer, K. J., Hill, A. V. S., Bejon, P., Hamaluba, M.
Wellcome Open Res, (2023). 8:450
Safety and immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccine in adults in Kenya: a phase 1/2 single-blind, randomised controlled trial.
Hamaluba, M., Sang, S., Orindi, B., Njau, I., Karanja, H., Kamau, N., Gitonga, J. N., Mugo, D., Wright, D., Nyagwange, J., Kutima, B., Omuoyo, D., Mwatasa, M., Ngetsa, C., Agoti, C., Cheruiyot, S., Nyaguara, A., Munene, M., Mturi, N., Oloo, E., Ochola-Oyier, L., Mumba, N., Mauncho, C., Namayi, R., Davies, A., Tsofa, B., Nduati, E. W., Aliyan, N., Kasera, K., Etyang, A., Boyd, A., Hill, A., Gilbert, S., Douglas, A., Pollard, A., Bejon, P., Lambe, T., Warimwe, G.
Wellcome Open Res, (2023). 8:182
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
Datoo, M. S., Dicko, A., Tinto, H., Ouédraogo, J. B., Hamaluba, M., Olotu, A., Beaumont, E., Ramos Lopez, F., Natama, H. M., Weston, S., Chemba, M., Compaore, Y. D., Issiaka, D., Salou, D., Some, A. M., Omenda, S., Lawrie, A., Bejon, P., Rao, H., Chandramohan, D., Roberts, R., Bharati, S., Stockdale, L., Gairola, S., Greenwood, B. M., Ewer, K. J., Bradley, J., Kulkarni, P. S., Shaligram, U., Hill, A. V. S.
Lancet, (2024). 403:533-544