The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine



The Plasmodium falciparum erythrocyte membrane protein 1 antigens that are inserted onto the surface of P. falciparum infected erythrocytes play a key role both in the pathology of severe malaria and as targets of naturally acquired immunity. They might be considered unlikely vaccine targets because they are extremely diverse. However, several lines of evidence suggest that underneath this molecular diversity there are a restricted set of epitopes which may act as effective targets for a vaccine against severe malaria. Here we review some of the recent developments in this area of research, focusing on work that has assessed the potential of these molecules as possible vaccine targets.

Bull, P. C., Abdi, A. I.

Pages:171-86, Volume:143, Edition:1/8/2016, Date,Feb


Notes:Bull, Peter C|Abdi, Abdirahman I|eng|103956/Wellcome Trust/United Kingdom|084538/Wellcome Trust/United Kingdom|Research Support, Non-U.S. Gov’t|Review|England|2016/01/08 06:00|Parasitology. 2016 Feb;143(2):171-86. doi: 10.1017/S0031182015001274. Epub 2016 Jan 7.

ISBN: 1469-8161 (Electronic)|0031-1820 (Linking) Permanent ID: PMC4825093 Accession Number: 26741401

Author Address: Department of Pathology,University of Cambridge,Tennis Court Rd,Cambridge CB2 1QP,UK.