J Infect Dis
Malaria-specific antibody responses in children often appear to be short-lived but the mechanisms underlying this phenomenon are not well understood. In this study, we investigated the relationship between the B-cell activating factor (BAFF) and its receptors expressed on B cells with antibody responses during and after acute malaria in children. Our results demonstrate that BAFF plasma levels increased during acute malarial disease and reflected disease severity. The expression profiles for BAFF receptors on B cells agreed with rapid activation and differentiation of a proportion of B cells to plasma cells. However, BAFF receptor (BAFF-R) expression was reduced on all peripheral blood B cells during acute infection, but those children with the highest level of BAFF-R expression on B cells maintained schizont-specific immunoglobin G (IgG) over a period of 4 months, indicating that dysregulation of BAFF-R expression on B cells may contribute to short-lived antibody responses to malarial antigens in children. In summary, this study suggests a potential role for BAFF during malaria disease, both as a marker for disease severity and in shaping the differentiation pattern of antigen-specific B cells.
Nduati, E., Gwela, A., Karanja, H., Mugyenyi, C., Langhorne, J., Marsh, K., Urban, B. C.
Pages:962-70, Volume:204, Edition:8/19/2011, Date,Sep-15
Notes:Nduati, Eunice|Gwela, Agnes|Karanja, Henry|Mugyenyi, Cleopatra|Langhorne, Jean|Marsh, Kevin|Urban, Britta C|U117584248/Department of Health/United Kingdom|Howard Hughes Medical Institute/United States|Research Support, Non-U.S. Gov’t|United States|The Journal of infectious diseases|J Infect Dis. 2011 Sep 15;204(6):962-70. doi: 10.1093/infdis/jir438.
ISBN: 1537-6613 (Electronic)|0022-1899 (Linking) Permanent ID: 3156925 Accession Number: 21849293
Author Address: KEMRI/Wellcome Trust Collaborative Research Program, Centre for Geographical Medicine Research, Kilifi, Kenya.