The Malaria-High Blood Pressure Hypothesis

ABSTRACT

Circ Res

RATIONALE: Several studies have demonstrated links between infectious diseases and cardiovascular conditions. Malaria and hypertension are widespread in many low- and middle-income countries, but the possible link between them has not been considered. OBJECTIVE: In this article, we outline the basis for a possible link between malaria and hypertension and discuss how the hypothesis could be confirmed or refuted. METHODS AND RESULTS: We reviewed published literature on factors associated with hypertension and checked whether any of these were also associated with malaria. We then considered various study designs that could be used to test the hypothesis. Malaria causes low birth weight, malnutrition, and inflammation, all of which are associated with hypertension in high-income countries. The hypothetical link between malaria and hypertension can be tested through the use of ecological, cohort, or Mendelian randomization studies, each of which poses specific challenges. CONCLUSIONS: Confirmation of the existence of a causative link with malaria would be a paradigm shift in efforts to prevent and control hypertension and would stimulate wider research on the links between infectious and noncommunicable disease.

Etyang, A. O., Smeeth, L., Cruickshank, J. K., Scott, J. A.

Pages:36-40, Volume:119, Edition:5/7/2016, Date,Jun-24

Link: https://www.ncbi.nlm.nih.gov/pubmed/27151400

Notes:Etyang, Anthony O|Smeeth, Liam|Cruickshank, J Kennedy|Scott, J Anthony G|eng|MR/K006584/1/Medical Research Council/United Kingdom|Review|2016/05/07 06:00|Circ Res. 2016 Jun 24;119(1):36-40. doi: 10.1161/CIRCRESAHA.116.308763. Epub 2016 May 5.

ISBN: 1524-4571 (Electronic)|0009-7330 (Linking) Permanent ID: PMC4920207 Accession Number: 27151400

Author Address: From the Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Program, Kilifi, Kenya (A.O.E., J.A.G.S.)| Department of Infectious Disease Epidemiology (A.O.E., J.A.G.S.), and Department of Non-Communicable Disease Epidemiology (L.S.), London School of Hygiene and Tropical Medicine, London, United Kingdom| and Cardiovascular Medicine Group, Division of Diabetes and Nutritional Sciences, King’s College, London, United Kingdom (J.K.C.). aetyang@kemri-wellcome.org.|From the Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Program, Kilifi, Kenya (A.O.E., J.A.G.S.)| Department of Infectious Disease Epidemiology (A.O.E., J.A.G.S.), and Department of Non-Communicable Disease Epidemiology (L.S.), London School of Hygiene and Tropical Medicine, London, United Kingdom| and Cardiovascular Medicine Group, Division of Diabetes and Nutritional Sciences, King’s College, London, United Kingdom (J.K.C.).

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