Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya


Nat Commun

Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.

Adetifa, I. M. O., Uyoga, S., Gitonga, J. N., Mugo, D., Otiende, M., Nyagwange, J., Karanja, H. K., Tuju, J., Wanjiku, P., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Ng’ang’a, W., Rombo, C., Yegon, C., Kithi, K., Odhiambo, E., Rotich, T., Orgut, I., Kihara, S., Bottomley, C., Kagucia, E. W., Gallagher, K. E., Etyang, A., Voller, S., Lambe, T., Wright, D., Barasa, E., Tsofa, B., Bejon, P., Ochola-Oyier, L. I., Agweyu, A., Scott, J. A. G., Warimwe, G. M.

Pages:3966, Volume:12, Edition:6/27/2021, Date,Jun-25

Link: https://www.ncbi.nlm.nih.gov/pubmed/34172732

Notes:Adetifa, Ifedayo M O|Uyoga, Sophie|Gitonga, John N|Mugo, Daisy|Otiende, Mark|Nyagwange, James|Karanja, Henry K|Tuju, James|Wanjiku, Perpetual|Aman, Rashid|Mwangangi, Mercy|Amoth, Patrick|Kasera, Kadondi|Ng’ang’a, Wangari|Rombo, Charles|Yegon, Christine|Kithi, Khamisi|Odhiambo, Elizabeth|Rotich, Thomas|Orgut, Irene|Kihara, Sammy|Bottomley, Christian|Kagucia, Eunice W|Gallagher, Katherine E|Etyang, Anthony|Voller, Shirine|Lambe, Teresa|Wright, Daniel|Barasa, Edwine|Tsofa, Benjamin|Bejon, Philip|Ochola-Oyier, Lynette I|Agweyu, Ambrose|Scott, J Anthony G|Warimwe, George M|eng|220991/Z/20/Z, 203077/Z/16/Z/Wellcome Trust (Wellcome)|214320/WT_/Wellcome Trust/United Kingdom|218647/WT_/Wellcome Trust/United Kingdom|MR/R006083/1/MRC_/Medical Research Council/United Kingdom|MR/S005293/1/MRC_/Medical Research Council/United Kingdom|203077/WT_/Wellcome Trust/United Kingdom|107568/WT_/Wellcome Trust/United Kingdom|222574/WT_/Wellcome Trust/United Kingdom|EP-C-15-003/EPA/EPA/|WT_/Wellcome Trust/United Kingdom|MR/R010161/1/MRC_/Medical Research Council/United Kingdom|220991/WT_/Wellcome Trust/United Kingdom|Research Support, Non-U.S. Gov’t|England|2021/06/27 06:00|Nat Commun. 2021 Jun 25;12(1):3966. doi: 10.1038/s41467-021-24062-3.

ISBN: 2041-1723 (Electronic)|2041-1723 (Linking) Permanent ID: PMC8233334 Accession Number: 34172732

Author Address: KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. IAdetifa@kemri-wellcome.org.|Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. IAdetifa@kemri-wellcome.org.|KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. SUyoga@kemri-wellcome.org.|KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.|Ministry of Health, Government of Kenya, Nairobi, Kenya.|Presidential Policy & Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya.|Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.|Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.|Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.