Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors



The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths were expected, but by 31 July 2020, there were only 20,636 cases and 341 deaths. However, the extent of SARS-CoV-2 exposure in the community remains unknown. We determined the prevalence of anti-SARS-CoV-2 immunoglobulin G among blood donors in Kenya in April-June 2020. Crude seroprevalence was 5.6% (174 of 3098). Population-weighted, test-performance-adjusted national seroprevalence was 4.3% (95% confidence interval, 2.9 to 5.8%) and was highest in urban counties Mombasa (8.0%), Nairobi (7.3%), and Kisumu (5.5%). SARS-CoV-2 exposure is more extensive than indicated by case-based surveillance, and these results will help guide the pandemic response in Kenya and across Africa.

Uyoga, S., Adetifa, I. M. O., Karanja, H. K., Nyagwange, J., Tuju, J., Wanjiku, P., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Ng’ang’a, W., Rombo, C., Yegon, C., Kithi, K., Odhiambo, E., Rotich, T., Orgut, I., Kihara, S., Otiende, M., Bottomley, C., Mupe, Z. N., Kagucia, E. W., Gallagher, K. E., Etyang, A., Voller, S., Gitonga, J. N., Mugo, D., Agoti, C. N., Otieno, E., Ndwiga, L., Lambe, T., Wright, D., Barasa, E., Tsofa, B., Bejon, P., Ochola-Oyier, L. I., Agweyu, A., Scott, J. A. G., Warimwe, G. M.

Pages:79-82, Volume:371, Edition:11/13/2020, Date,Jan-01


Notes:Uyoga, Sophie|Adetifa, Ifedayo M O|Karanja, Henry K|Nyagwange, James|Tuju, James|Wanjiku, Perpetual|Aman, Rashid|Mwangangi, Mercy|Amoth, Patrick|Kasera, Kadondi|Ng’ang’a, Wangari|Rombo, Charles|Yegon, Christine|Kithi, Khamisi|Odhiambo, Elizabeth|Rotich, Thomas|Orgut, Irene|Kihara, Sammy|Otiende, Mark|Bottomley, Christian|Mupe, Zonia N|Kagucia, Eunice W|Gallagher, Katherine E|Etyang, Anthony|Voller, Shirine|Gitonga, John N|Mugo, Daisy|Agoti, Charles N|Otieno, Edward|Ndwiga, Leonard|Lambe, Teresa|Wright, Daniel|Barasa, Edwine|Tsofa, Benjamin|Bejon, Philip|Ochola-Oyier, Lynette I|Agweyu, Ambrose|Scott, J Anthony G|Warimwe, George M|eng|HHSN272201400008C/AI/NIAID NIH HHS/|MR/R006083/1/MRC_/Medical Research Council/United Kingdom|MR/S005293/1/MRC_/Medical Research Council/United Kingdom|MR/R010161/1/MRC_/Medical Research Council/United Kingdom|EP-C-15-003/EPA/EPA/|WT_/Wellcome Trust/United Kingdom|Research Support, Non-U.S. Gov’t|2020/11/13 06:00|Science. 2021 Jan 1;371(6524):79-82. doi: 10.1126/science.abe1916. Epub 2020 Nov 11.

ISBN: 1095-9203 (Electronic)|0036-8075 (Linking) Permanent ID: PMC7877494 Accession Number: 33177105

Author Address: KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.|KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.|Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.|Ministry of Health, Government of Kenya, Nairobi, Kenya.|Presidential Policy and Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya.|Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.|Nuffield Department of Medicine, Oxford University, Oxford, UK.