Abstract

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

Pejoski, D. de Rham, C. Martinez-Murillo, P. Santoro, F. Auderset, F. Medaglini, D. Pozzi, G. Vono, M. Lambert, P. H. Huttner, A. Haks, M. C. Ottenhoff, T. H. M. Villard, J. Siegrist, C. A. Vebcon Consortium Vsv-Ebovac Consortium Vsv-Eboplus Consortium
NPJ Vaccines. 2020; 532

Permanent descriptor

https://doi.org/10.1038/s41541-020-0179-4

The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56(+) NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)(+) cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR(+) CD56(dim) or cytokine-responsive CD56(bright) NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.