Abstract

Abnormal blood flow and red blood cell deformability in severe malaria

Dondorp, A. M. Kager, P. A. Vreeken, J. White, N. J.
Parasitol Today. 2000; 16228-32

Permanent descriptor

https://doi.org/10.1016/s0169-4758(00)01666-5

Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria. Here, Arjen Dondorp and colleagues describe the various contributors to impaired microcirculatory flow in falciparum malaria: sequestration, rosetting and recent findings regarding impaired red blood cell deformability. The correlation with clinical findings and possible therapeutic consequences are discussed.