Abstract

Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies

Farrington, C. P. Firth, M. J. Moulton, L. H. Ravn, H. Andersen, P. K. Evans, S. Working Group on Non-specific Effects of, Vaccines
Trop Med Int Health. 2009; 14977-85

Permanent descriptor

https://doi.org/10.1111/j.1365-3156.2009.02302.x

We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.