Ally Olotu

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure.Olotu A Fegan G Wambua J Nyangweso G Awuondo KO Leach A Lievens M Leboulleux D Njuguna P Peshu N Marsh K Bejon P
N Engl J Med, (2013). 368:1111-20

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data.Bejon P White MT Olotu A Bojang K Lusingu JP Salim N Otsyula NN Agnandji ST Asante KP Owusu-Agyei S Abdulla S Ghani AC
Lancet Infect Dis, (2013). 13:319-27

Feedback of research findings for vaccine trials: experiences from two malaria vaccine trials involving healthy children on the Kenyan Coast.Gikonyo C Kamuya D Mbete B Njuguna P Olotu A Bejon P Marsh V Molyneux S
Dev World Bioeth, (2013). 13:48-56

Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.Roetynck S Olotu A Simam J Marsh K Stockinger B Urban B Langhorne J
PLoS One, (2013). 8:e55195

Approaching the community about screening children for a multicentre malaria vaccine trial.Lang TA Gould J von Seidlein L Lusingu JP Mshamu S Ismael S Liheluka E Kamuya D Mwachiro D Olotu A Njuguna P Bejon P Marsh V Molyneux C
Int Health, (2012). 4:47-54

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.Ibison F Olotu A Muema DM Mwacharo J Ohuma E Kimani D Marsh K Bejon P Ndungu FM
PLoS One, (2012). 7:e52939

A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E.Ndungu FM Mwacharo J Kimani D Kai O Moris P Jongert E Vekemans J Olotu A Bejon P
PLoS One, (2012). 7:e52870

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.Rts SClinical Trials Partnership Agnandji ST Lell B Fernandes JF Abossolo BP Methogo BG Kabwende AL Adegnika AA Mordmuller B Issifou S Kremsner PG Sacarlal J Aide P Lanaspa M Aponte JJ Machevo S Acacio S Bulo H Sigauque B Macete E Alonso P Abdulla S Salim N Minja R Mpina M Ahmed S Ali AM Mtoro AT Hamad AS Mutani P Tanner M Tinto H D'Alessandro U Sorgho H Valea I Bihoun B Guiraud I Kabore B Sombie O Guiguemde RT Ouedraogo JB Hamel MJ Kariuki S Oneko M Odero C Otieno K Awino N McMorrow M Muturi-Kioi V Laserson KF Slutsker L Otieno W Otieno L Otsyula N Gondi S Otieno A Owira V Oguk E Odongo G Woods JB Ogutu B Njuguna P Chilengi R Akoo P Kerubo C Maingi C Lang T Olotu A Bejon P Marsh K Mwambingu G Owusu-Agyei S Asante KP Osei-Kwakye K Boahen O Dosoo D Asante I Adjei G Kwara E Chandramohan D Greenwood B Lusingu J Gesase S Malabeja A Abdul O Mahende C Liheluka E Malle L Lemnge M Theander TG Drakeley C Ansong D Agbenyega T Adjei S Boateng HO Rettig T Bawa J Sylverken J Sambian D Sarfo A Agyekum A Martinson F Hoffman I Mvalo T Kamthunzi P Nkomo R Tembo T Tegha G Tsidya M Kilembe J Chawinga C Ballou WR Cohen J Guerra Y Jongert E Lapierre D Leach A Lievens M Ofori-Anyinam O Olivier A Vekemans J Carter T Kaslow D Leboulleux D Loucq C Radford A Savarese B Schellenberg D Sillman M Vansadia P
N Engl J Med, (2012). 367:2284-95

Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children.Ndungu FM Olotu A Mwacharo J Nyonda M Apfeld J Mramba LK Fegan GW Bejon P Marsh K
Proc Natl Acad Sci U S A, (2012). 109:8247-52

Estimating individual exposure to malaria using local prevalence of malaria infection in the field.Olotu A Fegan G Wambua J Nyangweso G Ogada E Drakeley C Marsh K Bejon P
PLoS One, (2012). 7:e32929

Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya.Midega JT Smith DL Olotu A Mwangangi JM Nzovu JG Wambua J Nyangweso G Mbogo CM Christophides GK Marsh K Bejon P
Nat Commun, (2012). 3:674

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.Rts SClinical Trials Partnership Agnandji ST Lell B Soulanoudjingar SS Fernandes JF Abossolo BP Conzelmann C Methogo BG Doucka Y Flamen A Mordmuller B Issifou S Kremsner PG Sacarlal J Aide P Lanaspa M Aponte JJ Nhamuave A Quelhas D Bassat Q Mandjate S Macete E Alonso P Abdulla S Salim N Juma O Shomari M Shubis K Machera F Hamad AS Minja R Mtoro A Sykes A Ahmed S Urassa AM Ali AM Mwangoka G Tanner M Tinto H D'Alessandro U Sorgho H Valea I Tahita MC Kabore W Ouedraogo S Sandrine Y Guiguemde RT Ouedraogo JB Hamel MJ Kariuki S Odero C Oneko M Otieno K Awino N Omoto J Williamson J Muturi-Kioi V Laserson KF Slutsker L Otieno W Otieno L Nekoye O Gondi S Otieno A Ogutu B Wasuna R Owira V Jones D Onyango AA Njuguna P Chilengi R Akoo P Kerubo C Gitaka J Maingi C Lang T Olotu A Tsofa B Bejon P Peshu N Marsh K Owusu-Agyei S Asante KP Osei-Kwakye K Boahen O Ayamba S Kayan K Owusu-Ofori R Dosoo D Asante I Adjei G Adjei G Chandramohan D Greenwood B Lusingu J Gesase S Malabeja A Abdul O Kilavo H Mahende C Liheluka E Lemnge M Theander T Drakeley C Ansong D Agbenyega T Adjei S Boateng HO Rettig T Bawa J Sylverken J Sambian D Agyekum A Owusu L Martinson F Hoffman I Mvalo T Kamthunzi P Nkomo R Msika A Jumbe A Chome N Nyakuipa D Chintedza J Ballou WR Bruls M Cohen J Guerra Y Jongert E Lapierre D Leach A Lievens M Ofori-Anyinam O Vekemans J Carter T Leboulleux D Loucq C Radford A Savarese B Schellenberg D Sillman M Vansadia P
N Engl J Med, (2011). 365:1863-75

Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.Olotu A Moris P Mwacharo J Vekemans J Kimani D Janssens M Kai O Jongert E Lievens M Leach A Villafana T Savarese B Marsh K Cohen J Bejon P
PLoS One, (2011). 6:e25786

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.Bejon P Turner L Lavstsen T Cham G Olotu A Drakeley CJ Lievens M Vekemans J Savarese B Lusingu J von Seidlein L Bull PC Marsh K Theander TG
PLoS One, (2011). 6:e21711

Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children.Bejon P Cook J Bergmann-Leitner E Olotu A Lusingu J Mwacharo J Vekemans J Njuguna P Leach A Lievens M Dutta S von Seidlein L Savarese B Villafana T Lemnge MM Cohen J Marsh K Corran PH Angov E Riley EM Drakeley CJ
J Infect Dis, (2011). 204:9-18

Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast.Kariuki SM Ikumi M Ojal J Sadarangani M Idro R Olotu A Bejon P Berkley JA Marsh K Newton CR
Brain, (2011). 134:1519-28

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.Olotu A Lusingu J Leach A Lievens M Vekemans J Msham S Lang T Gould J Dubois MC Jongert E Vansadia P Carter T Njuguna P Awuondo KO Malabeja A Abdul O Gesase S Mturi N Drakeley CJ Savarese B Villafana T Lapierre D Ballou WR Cohen J Lemnge MM Peshu N Marsh K Riley EM von Seidlein L Bejon P
Lancet Infect Dis, (2011). 11:102-9

Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya.Olotu A Fegan G Williams TN Sasi P Ogada E Bauni E Wambua J Marsh K Borrmann S Bejon P
PLoS One, (2010). 5:e15569

Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.Lusingu J Olotu A Leach A Lievens M Vekemans J Olivier A Benns S Olomi R Msham S Lang T Gould J Hallez K Guerra Y Njuguna P Awuondo KO Malabeja A Abdul O Gesase S Dekker D Malle L Ismael S Mturi N Drakeley CJ Savarese B Villafana T Ballou WR Cohen J Riley EM Lemnge MM Marsh K Bejon P von Seidlein L
PLoS One, (2010). 5:e14090

Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya.Bejon P Williams TN Liljander A Noor AM Wambua J Ogada E Olotu A Osier FH Hay SI Farnert A Marsh K
PLoS Med, (2010). 7:e1000304