Abstract

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Nzila AM, Kokwaro G, Winstanley PA, Marsh K, Ward SA
Trends Parasitol. 2004;20

Permenent descriptor

Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.