Abstract
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum
Nzila, A. M.
Kokwaro, G.
Winstanley, P. A.
Marsh, K.
Ward, S. A.
Trends Parasitol. 2004; 20109-12
Permanent descriptor
https://doi.org/10.1016/j.pt.2003.12.005Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.
