Carbonell-Estrany X
Simoes EAF
Bont LJ
Gentile A
Homaira N
Scotta MC
Stein RT
Torres JP
Sheikh J
Broor S
Khuri-Bulos N
Nokes DJ
Munywoki PK
Bassat Q
Sharma AK
Basnet S
Garba M
De Jesus-Cornejo J
Lupisan SP
Nunes MC
Divarathna M
Fullarton JR
Rodgers-Gray BS
Keary I
Renosa MDC
Verwey C
Moore DP
Noordeen F
Kabra S
do Vale MS
Paternina-De La Ossa R
Marino C
Figueras-Aloy J
Krilov L
Berezin E
Zar HJ
Paudel K
Safadi MAP
Dbaibo G
Jroundi I
Jha R
Rafeek RAM
Pinheiro RS
Bracht M
Muthugala R
Lanari M
Martinon-Torres F
Mitchell I
Irimu G
Pandey A
Krishnan A
Mejias A
da Costa MSC
Shrestha S
Pernica JM
de Carvalho FC
Jalango RE
Ibrahim H
Ewa A
Ensinck G
Ulloa-Gutierrez R
Miralha AL
Lucion MF
Hassan MZ
Akhtar Z
Aleem MA
Chowdhury F
Rojo P
Sande C
Musau A
Zaman K
Helena L
Arlant F
Ghimire P
Price A
Subedi KU
Brenes-Chacon H
Goswami DR
Rahman MZ
Hossain ME
Chisti MJ
Vain NE
Lim A
Chiu A
Papenburg J
Juarez MDV
Senaratne T
Arunasalam S
Strand TA
Ayuk A
Ogunrinde O
Tavares LVS
Garba C
Garba BI
Dawa J
Gordon M
Osoro E
Agoti CN
Nyawanda B
Ngama M
Tabu C
Mathew JL
Cornacchia A
Rai GK
Jain A
Giongo MS
Paes BA
Front Pediatr. 2022;101033125
INTRODUCTION: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures. METHODS: A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management. RESULTS: Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision. CONCLUSION: Seven key actions for improving RSV prevention and management in LMICs are proposed.
