Autoagglutination of malaria-infected red blood cells and malaria severity

Roberts DJ, Pain A, Kai O, Kortok M, Marsh K
Lancet. 2000;355

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Red blood cells infected with Plasmodium falciparum can adhere to each other and so form large autoagglutinates. We show that this phenotype is common in field isolates and is strongly associated with severe malaria.