Abstract

Measurement of quinine in filter paper-absorbed blood by high-performance liquid chromatography

Mberu EK, Ward SA, Winstanley PA, Watkins WM
J Chromatogr. 1991;570

Permenent descriptor

An adaptation of an existing high-performance liquid chromatographic assay is described for the measurement of quinine, within the therapeutic concentration range, in whole blood. This method, in particular the use of small blood samples which have been dried onto filter paper strips, has advantages for clinical and pharmacokinetic studies in the tropics on children with malaria.