Abstract

Sepsis: Changing Definitions, Unchanging Treatment

Obonyo, N. G. Schlapbach, L. J. Fraser, J. F.
Front Pediatr. 2018; 6425

Permanent descriptor

https://doi.org/10.3389/fped.2018.00425

The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle income country settings. It is therefore urgent to develop and validate standardized criteria for sepsis that can be applied to pediatric populations in different settings, including in- and outside intensive care, both in high- and low/middle- income countries. This will be a pre-requisite to evaluate the impact of sepsis treatment strategies to improve clinical outcomes.