MRC [MC_UU_12011/3, MC_UP_A620_1016] Funding Source: UKRI; Medical Research Council [U1475000003, MR/K012126/1] Funding Source: researchfish; Medical Research Council [MC_UU_12011/3, MC_UP_A620_1016] Funding Source: Medline; Wellcome Trust [100714, 091561, 203077] Funding Source: Medline; World Health Organization [001] Funding Source: Medline