Abstract

Rates of acquisition of pneumococcal colonization and transmission probabilities, by serotype, among newborn infants in Kilifi District, Kenya

Tigoi CC, Gatakaa H, Karani A, Mugo D, Kungu S, Wanjiru E, Jomo J, Musyimi R, Ojal J, Glass NE, Abdullahi O, Scott JA
Clin Infect Dis. 2012;55

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BACKGROUND: Herd protection and serotype replacement disease following introduction of pneumococcal conjugate vaccine (PCV) are attributable to the vaccine's impact on colonization. Prior to vaccine introduction in Kenya, we did an epidemiological study to estimate the rate of pneumococcal acquisition, by serotype, in an uncolonized population. METHODS: Nasopharyngeal swab specimens were taken from newborns aged