Abdirahman Abdi

Induction of an early IFN-γ cellular response and high plasma levels of SDF-1α are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients.Wanjiku P, Orindi B, Kimotho J, Sayed S, Shah R, Saleh M, Mwacharo J, Maronga C, Olouch V, Karanu A, Shah J, Nneka Z, Ochola-Oyier LI, Abdi AI, Dunachie S, Bejon P, Nduati EW, Ndungu FM
PLoS One, (2025). 20:e0316967

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.McLean FE, Omondi BR, Diallo N, Otoboh S, Kifude C, Abdi A, Lim R, Otto TD, Ghumra A, Rowe JA
PLoS Pathog, (2025). 21:e1012434

Antibodies to PfEMP1 and Variant Surface Antigens: Protection after Controlled Human Malaria Infection in Semi-immune Kenyan Adults.Kinyua AW, Turner L, Kimingi HW, Mwai K, Mwikali K, Andisi C, Sim BKL, Bejon P, Kapulu MC, Kinyanjui SM, Lavstsen T, Abdi AI
J Infect, (2024). 89:106252

The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria.Kioko M, Mwangi S, Pance A, Ochola-Oyier LI, Kariuki S, Newton C, Bejon P, Rayner JC, Abdi AI
Sci Adv, (2024). 10:eadl2256

Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis.Kioko M, Mwangi S, Njunge JM, Berkley JA, Bejon P, Abdi AI
Mol Neurobiol, (2024). :Online ahead of print

Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected.Kimenyi KM, Akinyi MY, Mwikali K, Gilmore T, Mwangi S, Omer E, Gichuki B, Wambua J, Njunge J, Obiero G, Bejon P, Langhorne J, Abdi A, Ochola-Oyier LI
BMC Infect Dis, (2024). 24:140

Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study.Kimotho J, Sein Y, Sayed S, Shah R, Mwai K, Saleh M, Wanjiku P, Mwacharo J, Nyagwange J, Karanja H, Kutima B, Gitonga JN, Mugo D, Karanu A, Moranga L, Oluoch V, Shah J, Mutiso J, Mburu A, Nneka Z, Betti P, Mutinda WU, Issak Abdi A, Bejon P, Ochola-Oyier LI, Warimwe GM, Nduati EW, Ndungu FM
Wellcome Open Res, (2023). 8:350

Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum.Kioko M, Pance A, Mwangi S, Goulding D, Kemp A, Rono M, Ochola-Oyier LI, Bull PC, Bejon P, Rayner JC, Abdi AI
Nature Communications, (2023). 14:6447

From contigs towards chromosomes: automatic improvement of long read assemblies (ILRA).Ruiz JL, Reimering S, Escobar-Prieto JD, Brancucci NMB, Echeverry DF, Abdi AI, Marti M, G�mez-D�az E, Otto TD
Brief Bioinform, (2023). 24:bbad248

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment.Abdi AI, Achcar F, Sollelis L, Silva-Filho JL, Mwikali K, Muthui M, Mwangi S, Kimingi HW, Orindi B, Andisi C, Alkema M, Chandrasekar A, Bull PC, Bejon P, Modrzynska K, Bousema T, Marti M
Elife, (2023). 12:e85140

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.Odera DO, Tuju J, Mwai K, Nkumama IN, F�rle K, Chege T, Kimathi R, Diehl S, Musasia FK, Rosenkranz M, Njuguna P, Hamaluba M, Kapulu MC, Frank R, Osier FHA, Abdi AI, Chi PC, de Laurent Z, Jao I, Kamuya D, Kamuyu G, Makale J, Murungi L, Musyoki J, Muthui M, Mwacharo J, Kariuki S, Mwanga D, Mwongeli J, Ndungu F, Njue M, Nyangweso G, Kimani D, Ngoi JM, Musembi J, Ngoto O, Otieno E, Ooko M, Shangala J, Wambua J, Mohammed KS, Omuoyo D, Mosobo M, Kibinge N, Kinyanjui S, Bejon P, Lowe B, Marsh K, Marsh V, Abebe Y, Billingsley PF, Sim BKL, Hoffman SL, James ER, Richie TL, Audi A, Olewe F, Oloo J, Ongecha J, Ongas MO, Koskei N, Bull PC, Hodgson SH, Kivisi C, Imwong M, Murphy SC, Ogutu B, Tarning J, Winterberg M, Williams TN
Sci Transl Med, (2023). 15:eabn5993

A pragmatic randomized controlled trial of standard care versus corticosteroids plus standard care for treatment of pneumonia in adults admitted to Kenyan hospitals (SONIA).Lucinde R, Abdi A, Orindi B, Mwakio S, Gathuri H, Onyango E, Chira S, Ogero M, Isaaka L, Shangala J, Oginga IN, Wachira A, Manuthu E, Kariuki H, Nyikuli J, Wekesa C, Otedo A, Bosire H, Okoth SB, Ongalo W, Mukabi D, Lusamba W, Muthui B, Kirui N, Adembesa I, Mithi C, Sood M, Ahmed N, Gituma B, Ongaki VB, Giabe M, Omondi C, Ombajo LA, Kagucia W, English M, Hamaluba M, Ochola-Oyier LI, Kamuya D, Bejon P, Agweyu A, Akech S, Etyang AO
Wellcome Open Res, (2022). 7:269

Analysis of var Gene Transcription Pattern Using DBLalpha Tags.Andisi KC, Abdi AI
Methods Mol Biol, (2022). 2470:173-184

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018.Kimenyi KM, Wamae K, Ngoi JM, de Laurent ZR, Ndwiga L, Osoti V, Obiero G, Abdi AI, Bejon P, Ochola-Oyier LI
Malar J, (2022). 21:192

Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study.Kimingi HW, Kinyua AW, Achieng NA, Wambui KM, Mwangi S, Nguti R, Kivisi CA, Jensen ATR, Bejon P, Kapulu MC, Abdi AI, Kinyanjui SM, CHMI-SIKA Study Team
Front Immunol, (2022). 13:894770

Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition.Maghraby MK, Li B, Chi L, Ling C, Benmoussa A, Provost P, Postmus AC, Abdi A, Pierro A, Bourdon C, Bandsma RHJ
Sci Rep, (2021). 11:7635

Exploring Plasmodium falciparum Var Gene Expression to Assess Host Selection Pressure on Parasites During Infancy.Kivisi CA, Muthui M, Hunt M, Fegan G, Otto TD, Githinji G, Warimwe GM, Rance R, Marsh K, Bull PC, Abdi AI
Front Immunol, (2019). 10:2328

No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites.Wamae K, Okanda D, Ndwiga L, Osoti V, Kimenyi KM, Abdi AI, Bejon P, Sutherland C, Ochola-Oyier LI
Antimicrob Agents Chemother, (2019). :

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).Tuju J, Mackinnon MJ, Abdi AI, Karanja H, Musyoki JN, Warimwe GM, Gitau EN, Marsh K, Bull PC, Urban BC
PLoS Pathog, (2019). 15:e1007870

Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres.Otto TD, Bohme U, Sanders M, Reid A, Bruske EI, Duffy CW, Bull PC, Pearson RD, Abdi A, Dimonte S, Stewart LB, Campino S, Kekre M, Hamilton WL, Claessens A, Volkman SK, Ndiaye D, Amambua-Ngwa A, Diakite M, Fairhurst RM, Conway DJ, Franck M, Newbold CI, Berriman M
Wellcome Open Res, (2018). 3:52