clinicalresearch/Wellcome Open Res

Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples.Malaria Genomic Epidemiology Network Abdel Hamid MM Abdelraheem MH Acheampong DO Adam I Aide P Ajibaye O Ali M Almagro-Garcia J Amambua-Ngwa A Amenga-Etego L Aniebo I Aninagyei E Ansah F Apinjoh TO Ariani CV Auburn S Awandare GA Balmer A Bejon P Boene S Bwire G Candrinho B Chidimatembue A Chindavongsa K Comiche K Conway D Dara A Diakite M Djimde A Dondorp A Doumbia S Drury E Fanello CA Ferdig M Figueroa K Gamboa D Golassa L Goncalves S Guindo MDA Hamaluba M Hanboonkunupakarn B Howe K Hussien M Imwong M Ishengoma D Jeans J Kabaghe A Kamuhabwa A Kindermans JM Konate DS Kwiatkowski DP Lee C Lee SK Lee SJ Ley B Llanos-Cuentas A Marfurt J Matambisso G Maude RR Maude RJ Mayor A Mayxay M Maiga-Ascofare O McCann RS Miles A Miotto O Mohamed AO Morang'a CM Murie K Ngasala BE Nguyen TN Nolasco O Nosten F Noviyanti R O'Connor I Oboh M Ochola-Oyier LI Olufunke Falade C Olukosi A Olumide A Olusola FI Onyamboko MA Oriero EC Oyibo WA Pannebaker D Pearson RD Phiri K van der Pluijm RW Price RN Quang HH Rajkumar Devaraju V Randrianarivelojosia M Ranford-Cartwright L Rayner JC Rovira-Vallbona E Rowlands K Ruano-Rubio V Sanchez JF Saute F Shettima S da Silva C Simpson VJ Suddaby S Takken W Thu AM Toure M Unlu E Valdivia HO van Vugt M Waithira N Wellems T Wendler J White N Wuendrich Ogidan R
Wellcome Open Res, (2025). 10:325

A pragmatic randomized controlled trial of standard care versus corticosteroids plus standard care for treatment of pneumonia in adults admitted to Kenyan hospitals (SONIA).Lucinde R Abdi A Orindi B Mwakio S Gathuri H Onyango E Chira S Ogero M Isaaka L Shangala J Oginga IN Wachira A Manuthu E Kariuki H Nyikuli J Wekesa C Otedo A Bosire H Okoth SB Ongalo W Mukabi D Lusamba W Muthui B Kirui N Adembesa I Mithi C Sood M Ahmed N Gituma B Ongaki VB Giabe M Omondi C Ombajo LA Kagucia W English M Hamaluba M Ochola-Oyier LI Kamuya D Bejon P Agweyu A Akech S Etyang AO
Wellcome Open Res, (2025). 7:269

SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART).Maitland K Hamaluba M Obonyo N Oguda E Mogoka C Williams TN Chaponda M Miti S Kamavu LK Jonathan Gwasupika J Connon R Gibb DM Dondorp A Day N White N Walker AS George EC Severe Malaria in African Children AResearch Trials consortium
Wellcome Open Res, (2024). 8:484

A Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial).Maitland K Obonyo N Hamaluba M Ogoda E Mogaka C Williams TN Newton C Kariuki SM Gibb DM Walker AS Connon R George EC
Wellcome Open Res, (2024). 9:281

Mortality among non-severely under nourished children with pneumonia globally: protocol for a systematic review and meta-analysis.Nalwanga D Bakker C Kiggwe A Negash AA Ocan M Briend A Maitland K Musiiime V Karamagi C
Wellcome Open Res, (2024). 8:551

Therapeutic monitoring of anti-seizure medications in low- and middle-income countries: a systematic review.Odhiambo M Kariuki SM Newton CR
Wellcome Open Res, (2024). 6:92

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial.Wamae K Ndwiga L Kharabora O Kimenyi K Osoti V de Laurent Z Wambua J Musyoki J Ngetsa C Kalume P Mwambingu G Hamaluba M van der Pluijm R Dondorp AM Bailey J Juliano J Bejon P Ochola-Oyier L
Wellcome Open Res, (2024). 7:95

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol.Olupot-Olupot P Aloroker F Mpoya A Mnjalla H Paasi G Nakuya M Houston K Obonyo N Hamaluba M Evans JA Dewez M Atti S Guindo O Ouattara SM Chara A Sainna HA Amos OO Ogundipe O Sunyoto T Coldiron M Langendorf C Scherrer MF Petrucci R Connon R George EC Gibb DM Maitland K
Wellcome Open Res, (2024). 6:160

Safety and immunogenicity of varied doses of R21/Matrix-M vaccine at three years follow-up: A phase 1b age de-escalation, dose-escalation trial in adults, children, and infants in Kilifi-Kenya.Sang S Datoo MS Otieno E Muiruri C Bellamy D Gathuri E Ngoto O Musembi J Provstgaard-Morys S Stockdale L Aboagye J Woods D Lawrie A Roberts R Keter K Kimani D Ndungu F Kapulu M Njau I Orindi B Ewer KJ Hill AVS Bejon P Hamaluba M
Wellcome Open Res, (2023). 8:450

Safety and immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccine in adults in Kenya: a phase 1/2 single-blind, randomised controlled trial.Hamaluba M Sang S Orindi B Njau I Karanja H Kamau N Gitonga JN Mugo D Wright D Nyagwange J Kutima B Omuoyo D Mwatasa M Ngetsa C Agoti C Cheruiyot S Nyaguara A Munene M Mturi N Oloo E Ochola-Oyier L Mumba N Mauncho C Namayi R Davies A Tsofa B Nduati EW Aliyan N Kasera K Etyang A Boyd A Hill A Gilbert S Douglas A Pollard A Bejon P Lambe T Warimwe G COVVaccine Trial Group
Wellcome Open Res, (2023). 8:182

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.Olupot-Olupot P Okiror W Mnjalla H Muhindo R Uyoga S Mpoya A Williams TN terHeine R Burger DM Urban B Connon R George EC Gibb DM Walker AS Maitland K
Wellcome Open Res, (2023). 6:161

Strategies for improving mental health and wellbeing used by adults ageing with HIV from the Kenyan coast: a qualitative exploration.Mwangala PN Wagner RG Newton CR Abubakar A
Wellcome Open Res, (2023). 7:221

Development of a legume-enriched feed for treatment of severe acute malnutrition.Walsh K Delamare de la Villenaise de Chenevarin G McGurk J Maitland K Frost G
Wellcome Open Res, (2023). 6:206

Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples.MalariaGen, Abdel Hamid MM Abdelraheem MH Acheampong DO Ahouidi A Ali M Almagro-Garcia J Amambua-Ngwa A Amaratunga C Amenga-Etego L Andagalu B Anderson T Andrianaranjaka V Aniebo I Aninagyei E Ansah F Ansah PO Apinjoh T Arnaldo P Ashley E Auburn S Awandare GA Ba H Baraka V Barry A Bejon P Bertin GI Boni MF Borrmann S Bousema T Bouyou-Akotet M Branch O Bull PC Cheah H Chindavongsa K Chookajorn T Chotivanich K Claessens A Conway DJ Corredor V Courtier E Craig A D'Alessandro U Dama S Day N Denis B Dhorda M Diakite M Djimde A Dolecek C Dondorp A Doumbia S Drakeley C Drury E Duffy P Echeverry DF Egwang TG Enosse SMM Erko B Fairhurst RM Faiz A Fanello CA Fleharty M Forbes M Fukuda M Gamboa D Ghansah A Golassa L Goncalves S Harrison GLA Healy SA Hendry JA Hernandez-Koutoucheva A Hien TT Hill CA Hombhanje F Hott A Htut Y Hussein M Imwong M Ishengoma D Jackson SA Jacob CG Jeans J Johnson KJ Kamaliddin C Kamau E Keatley J Kochakarn T Konate DS Konate A Kone A Kwiatkowski DP Kyaw MP Kyle D Lawniczak M Lee SK Lemnge M Lim P Lon C Loua KM Mandara CI Marfurt J Marsh K Maude RJ Mayxay M Maiga-Ascofare O Miotto O Mita T Mobegi V Mohamed AO Mokuolu OA Montgomery J Morang'a CM Mueller I Murie K Newton PN Ngo Duc T Nguyen T Nguyen TN Nguyen Thi Kim T Nguyen Van H Noedl H Nosten F Noviyanti R Ntui VN Nzila A Ochola-Oyier LI Ocholla H Oduro A Omedo I Onyamboko MA Ouedraogo JB Oyebola K Oyibo WA Pearson R Peshu N Phyo AP Plowe CV Price RN Pukrittayakamee S Quang HH Randrianarivelojosia M Rayner JC Ringwald P Rosanas-Urgell A Rovira-Vallbona E Ruano-Rubio V Ruiz L Saunders D Shayo A Siba P Simpson VJ Sissoko MS Smith C Su XZ Sutherland C Takala-Harrison S Talman A Tavul L Thanh NV Thathy V Thu AM Toure M Tshefu A Verra F Vinetz J Wellems TE Wendler J White NJ Whitton G Yavo W van der Pluijm RW
Wellcome Open Res, (2023). 8:22

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults).Abouyannis M FitzGerald R Ngama M Mwangudzah H Nyambura YK Ngome S Riako D Babu L Lewa F Else L Dily Penchala S Orindi B Mumba N Kalama B Ndungu FM Adetifa I Khoo S Lalloo DG Casewell NR Hamaluba M
Wellcome Open Res, (2022). 7:90

Barriers to access and utilization of healthcare by children with neurological impairments and disability in low-and middle-income countries: a systematic review.Mwangi LW Abuga JA Cottrell E Kariuki SM Kinyanjui SM Newton CR
Wellcome Open Res, (2022). 6:61

Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.Kiguli S Olopot-Olupot P Alaroker F Engoru C Opoka RO Tagoola A Hamaluba M Mnjalla H Mpoya A Mogaka C Nalwanga D Nabawanuka E Nokes J Nyaigoti C Briend A van Woensel JBM Grieve R Sadique Z Williams TN Thomas K Harrison DA Rowan K Maitland K
Wellcome Open Res, (2021). 6:221

Validity and reliability of the Neurodevelopmental Screening Tool (NDST) in screening for neurodevelopmental disorders in children living in rural Kenyan coast.Bitta MA Kipkemoi P Kariuki SM Abubakar A Gona J Philips-Owen J Newton CR
Wellcome Open Res, (2021). 6:137

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples.MalariaGen, Ahouidi A Ali M Almagro-Garcia J Amambua-Ngwa A Amaratunga C Amato R Amenga-Etego L Andagalu B Anderson TJC Andrianaranjaka V Apinjoh T Ariani C Ashley EA Auburn S Awandare GA Ba H Baraka V Barry AE Bejon P Bertin GI Boni MF Borrmann S Bousema T Branch O Bull PC Busby GBJ Chookajorn T Chotivanich K Claessens A Conway D Craig A D'Alessandro U Dama S Day NP Denis B Diakite M Djimde A Dolecek C Dondorp AM Drakeley C Drury E Duffy P Echeverry DF Egwang TG Erko B Fairhurst RM Faiz A Fanello CA Fukuda MM Gamboa D Ghansah A Golassa L Goncalves S Hamilton WL Harrison GLA Hart L Henrichs C Hien TT Hill CA Hodgson A Hubbart C Imwong M Ishengoma DS Jackson SA Jacob CG Jeffery B Jeffreys AE Johnson KJ Jyothi D Kamaliddin C Kamau E Kekre M Kluczynski K Kochakarn T Konate A Kwiatkowski DP Kyaw MP Lim P Lon C Loua KM Maiga-Ascofare O Malangone C Manske M Marfurt J Marsh K Mayxay M Miles A Miotto O Mobegi V Mokuolu OA Montgomery J Mueller I Newton PN Nguyen T Nguyen TN Noedl H Nosten F Noviyanti R Nzila A Ochola-Oyier LI Ocholla H Oduro A Omedo I Onyamboko MA Ouedraogo JB Oyebola K Pearson RD Peshu N Phyo AP Plowe CV Price RN Pukrittayakamee S Randrianarivelojosia M Rayner JC Ringwald P Rockett KA Rowlands K Ruiz L Saunders D Shayo A Siba P Simpson VJ Stalker J Su XZ Sutherland C Takala-Harrison S Tavul L Thathy V Tshefu A Verra F Vinetz J Wellems TE Wendler J White NJ Wright I Yavo W Ye H
Wellcome Open Res, (2021). 6:42

Mortality during and following hospital admission among school-aged children: a cohort study.Ngari MM Obiero C Mwangome MK Nyaguara A Mturi N Murunga S Otiende M Iversen PO Fegan GW Walson JL Berkley JA
Wellcome Open Res, (2020). 5:234