Isabella Ochola-Oyier

Peripheral blood mononuclear cell transcriptomes reveal an over-representation of down-regulated genes associated with immunity in HIV-exposed uninfected infants.Musimbi ZD, Rono MK, Otieno JR, Kibinge N, Ochola-Oyier LI, de Villiers EP, Nduati EW
Sci Rep, (2019). 9:18124

Understanding P. falciparum Asymptomatic Infections: A Proposition for a Transcriptomic Approach.Kimenyi KM, Wamae K, Ochola-Oyier LI
Front Immunol, (2019). 10:2398

No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites.Wamae K, Okanda D, Ndwiga L, Osoti V, Kimenyi KM, Abdi AI, Bejon P, Sutherland C, Ochola-Oyier LI
Antimicrob Agents Chemother, (2019). :

Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook.Ghansah A, Kamau E, Amambua-Ngwa A, Ishengoma DS, Maiga-Ascofare O, Amenga-Etego L, Deme A, Yavo W, Randrianarivelojosia M, Plasmodium Diversity Network Africa, Ochola-Oyier LI, Helegbe GK, Bailey J, Alifrangis M, Djimde A
Malar J, (2019). 18:324

Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection.Ochola-Oyier LI, Wamae K, Omedo I, Ogola C, Matharu A, Musabyimana JP, Njogu FK, Marsh K
Infect Genet Evol, (2019). 69:235-245

Transmission and Age Impact the Risk of Developing Febrile Malaria in Children with Asymptomatic Plasmodium falciparum Parasitemia.Wamae K, Wambua J, Nyangweso G, Mwambingu G, Osier F, Ndung'u F, Bejon P, Ochola-Oyier LI
J Infect Dis, (2019). 219:936-944

Polymorphisms in the K13 Gene in Plasmodium falciparum from Different Malaria Transmission Areas of Kenya.de Laurent ZR, Chebon LJ, Ingasia LA, Akala HM, Andagalu B, Ochola-Oyier LI, Kamau E
Am J Trop Med Hyg, (2018). 98:1360-1366

Geographic-genetic analysis of Plasmodium falciparum parasite populations from surveys of primary school children in Western Kenya.Omedo I, Mogeni P, Rockett K, Kamau A, Hubbart C, Jeffreys A, Ochola-Oyier LI, de Villiers EP, Gitonga CW, Noor AM, Snow RW, Kwiatkowski D, Bejon P
Wellcome Open Res, (2017). 2:29

Implications from predicted B-cell and T-cell epitopes of Plasmodium falciparum merozoite proteins EBA175-RII and Rh5.Wamae KK, Ochola-Oyier LI
Bioinformation, (2016). 12:82-91

Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population.Ochola-Oyier LI, Okombo J, Wagatua N, Ochieng J, Tetteh KK, Fegan G, Bejon P, Marsh K
Malar J, (2016). 15:261

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.Ochola-Oyier LI, Okombo J, Mwai L, Kiara SM, Pole L, Tetteh KK, Nzila A, Marsh K
Antimicrob Agents Chemother, (2015). 59:1770-5

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya.Okombo J, Kamau AW, Marsh K, Sutherland CJ, Ochola-Oyier LI
Int J Parasitol Drugs Drug Resist, (2014). 4:152-63

Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.Kiboi D, Irungu B, Orwa J, Kamau L, Ochola-Oyier LI, Nganga J, Nzila A
Exp Parasitol, (2014). 147:23-32

Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.Okombo J, Abdi AI, Kiara SM, Mwai L, Pole L, Sutherland CJ, Nzila A, Ochola-Oyier LI
Antimicrob Agents Chemother, (2013). 57:6196-204

The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.Okombo J, Zongo I, Gadalla N, Bousema T, Beshir KB, Roper C, Hallett R, Ochola-Oyier LI, Sutherland CJ
Antimicrob Agents Chemother, (2013). 57:4595-8

In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.Okombo J, Kiara SM, Rono J, Mwai L, Pole L, Ohuma E, Borrmann S, Ochola LI, Nzila A
Antimicrob Agents Chemother, (2010). 54:3302-7

Allele frequency-based and polymorphism-versus-divergence indices of balancing selection in a new filtered set of polymorphic genes in Plasmodium falciparum.Ochola LI, Tetteh KK, Stewart LB, Riitho V, Marsh K, Conway DJ
Mol Biol Evol, (2010). 27:2344-51

In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.Kiara SM, Okombo J, Masseno V, Mwai L, Ochola I, Borrmann S, Nzila A
Antimicrob Agents Chemother, (2009). 53:3793-8

Prospective identification of malaria parasite genes under balancing selection.Tetteh KK, Stewart LB, Ochola LI, Amambua-Ngwa A, Thomas AW, Marsh K, Weedall GD, Conway DJ
PLoS One, (2009). 4:e5568

Challenges in retaining research scientists beyond the doctoral level in Kenya.Ochola LI, Gitau E
PLoS Negl Trop Dis, (2009). 3:e345