Publications

Epidemiology and Demography

Risk factors for mortality and effect of correct fluid prescription in children with diarrhoea and dehydration without severe acute malnutrition admitted to Kenyan hospitals: an observational, association study.Akech, S. Ayieko, P. Gathara, D. Agweyu, A. Irimu, G. Stepniewska, K. English, M. Clinical Information Network, authors
Lancet Child Adolesc Health, (2018). 2:516-524

Caregiver oral rehydration solution fluid monitoring charts versus standard care for the management of some dehydration among Kenyan children: a randomized controlled trial.Kailemia, M. Kariuki, N. Laving, A. Agweyu, A. Wamalwa, D.
Int Health, (2018). 10:442-450

Prevalence, outcome and quality of care among children hospitalized with severe acute malnutrition in Kenyan hospitals: A multi-site observational study.Gachau, S. Irimu, G. Ayieko, P. Akech, S. Agweyu, A. English, M. Clinical Information Network Author, Group
PLoS One, (2018). 13:e0197607

Human Coronavirus NL63 Molecular Epidemiology and Evolutionary Patterns in Rural Coastal Kenya.Kiyuka, P. K. Agoti, C. N. Munywoki, P. K. Njeru, R. Bett, A. Otieno, J. R. Otieno, G. P. Kamau, E. Clark, T. G. van der Hoek, L. Kellam, P. Nokes, D. J. Cotten, M.
J Infect Dis, (2018). 217:1728-1739

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia.Opi, D. H. Swann, O. Macharia, A. Uyoga, S. Band, G. Ndila, C. M. Harrison, E. M. Thera, M. A. Kone, A. K. Diallo, D. A. Doumbo, O. K. Lyke, K. E. Plowe, C. V. Moulds, J. M. Shebbe, M. Mturi, N. Peshu, N. Maitland, K. Raza, A. Kwiatkowski, D. P. Rockett, K. A. Williams, T. N. Rowe, J. A.
Elife, (2018). 7:

Continuous Invasion by Respiratory Viruses Observed in Rural Households During a Respiratory Syncytial Virus Seasonal Outbreak in Coastal Kenya.Munywoki, P. K. Koech, D. C. Agoti, C. N. Cane, P. A. Medley, G. F. Nokes, D. J.
Clin Infect Dis, (2018). 67:1559-1567

Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial.Mallewa, J. Szubert, A. J. Mugyenyi, P. Chidziva, E. Thomason, M. J. Chepkorir, P. Abongomera, G. Baleeta, K. Etyang, A. Warambwa, C. Melly, B. Mudzingwa, S. Kelly, C. Agutu, C. Wilkes, H. Nkomani, S. Musiime, V. Lugemwa, A. Pett, S. L. Bwakura-Dangarembizi, M. Prendergast, A. J. Gibb, D. M. Walker, A. S. Berkley, J. A. Reality trial team
Lancet HIV, (2018). 5:e231-e240

Sickle Cell Anemia and Its Phenotypes.Williams, T. N. Thein, S. L.
Annu Rev Genomics Hum Genet, (2018). 19:113-147

Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children.Gilchrist, J. J. Mentzer, A. J. Rautanen, A. Pirinen, M. Mwarumba, S. Njuguna, P. Mturi, N. Wellcome Trust Case-Control, Consortium Kenyan Bacteraemia Study, Group Williams, T. N. Scott, J. A. G. Hill, A. V. S.
Proc Natl Acad Sci U S A, (2018). 115:E3601-E3603

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.Gilchrist, J. J. Rautanen, A. Fairfax, B. P. Mills, T. C. Naranbhai, V. Trochet, H. Pirinen, M. Muthumbi, E. Mwarumba, S. Njuguna, P. Mturi, N. Msefula, C. L. Gondwe, E. N. MacLennan, J. M. Chapman, S. J. Molyneux, M. E. Knight, J. C. Spencer, C. C. A. Williams, T. N. MacLennan, C. A. Scott, J. A. G. Hill, A. V. S.
Nat Commun, (2018). 9:1014

Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa.Aramburo, A. Todd, J. George, E. C. Kiguli, S. Olupot-Olupot, P. Opoka, R. O. Engoru, C. Akech, S. O. Nyeko, R. Mtove, G. Gibb, D. M. Babiker, A. G. Maitland, K.
BMC Med, (2018). 16:37

Approaching quality improvement at scale: a learning health system approach in Kenya.Irimu, G. Ogero, M. Mbevi, G. Agweyu, A. Akech, S. Julius, T. Nyamai, R. Githang'a, D. Ayieko, P. English, M. Clinical Information Network Authors, Group
Arch Dis Child, (2018). 103:1013-1019

Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya.Brent, A. J. Nyundo, C. Langat, J. Mulunda, C. Wambua, J. Bauni, E. Sande, J. Park, K. Williams, T. N. Newton, C. R. J. Levin, M. Scott, J. A. G. Kids Tb Study Group
Emerg Infect Dis, (2018). 24:514-523

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.Taylor, W. R. Naw, H. K. Maitland, K. Williams, T. N. Kapulu, M. D'Alessandro, U. Berkley, J. A. Bejon, P. Okebe, J. Achan, J. Amambua, A. N. Affara, M. Nwakanma, D. van Geertruyden, J. P. Mavoko, M. Lutumba, P. Matangila, J. Brasseur, P. Piola, P. Randremanana, R. Lasry, E. Fanello, C. Onyamboko, M. Schramm, B. Yah, Z. Jones, J. Fairhurst, R. M. Diakite, M. Malenga, G. Molyneux, M. Rwagacondo, C. Obonyo, C. Gadisa, E. Aseffa, A. Loolpapit, M. Henry, M. C. Dorsey, G. John, C. Sirima, S. B. Barnes, K. I. Kremsner, P. Day, N. P. White, N. J. Mukaka, M.
BMC Med, (2018). 16:11

Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa.McGann, P. T. Williams, T. N. Olupot-Olupot, P. Tomlinson, G. A. Lane, A. Luis Reis da Fonseca, J. Kitenge, R. Mochamah, G. Wabwire, H. Stuber, S. Howard, T. A. McElhinney, K. Aygun, B. Latham, T. Santos, B. Tshilolo, L. Ware, R. E. Reach Investigators
Am J Hematol, (2018). 93:537-545

Appropriateness of clinical severity classification of new WHO childhood pneumonia guidance: a multi-hospital, retrospective, cohort study.Agweyu, A. Lilford, R. J. English, M. Clinical Information Network Author, Group
Lancet Glob Health, (2018). 6:e74-e83

Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria.Kotlyar, S. Olupot-Olupot, P. Nteziyaremye, J. Akech, S. O. Uyoga, S. Muhindo, R. Moore, C. L. Maitland, K.
Pediatr Crit Care Med, (2018). 19:179-185

The clinical epidemiology of sickle cell anemia In Africa.Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, C. M. Nyutu, G. Makale, J. Tendwa, M. Nyatichi, E. Ojal, J. Shebe, M. Awuondo, K. O. Mturi, N. Peshu, N. Tsofa, B. Scott, J. A. G. Maitland, K. Williams, T. N.
Am J Hematol, (2018). 93:363-370

Comparable outcomes among trial and nontrial participants in a clinical trial of antibiotics for childhood pneumonia: a retrospective cohort study.Agweyu, A. Oliwa, J. Gathara, D. Muinga, N. Allen, E. Lilford, R. J. English, M.
J Clin Epidemiol, (2018). 94:1-7

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait.Etyang, A. O. Wandabwa, C. K. Kapesa, S. Muthumbi, E. Odipo, E. Wamukoya, M. Ngomi, N. Haregu, T. Kyobutungi, C. Williams, T. N. Makale, J. Macharia, A. Cruickshank, J. K. Smeeth, L. Scott, J. A. G.
Am J Epidemiol, (2018). 187:199-205