Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania


J Clin Hypertens (Greenwich)

People with HIV (PWH) have a >2-fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24-h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case-control study of ABPM in 137 PWH and HIV-uninfected controls with normal and high clinic blood pressure (BP) in Tanzania. Nocturnal non-dipping of heart rate (HR) was significantly more common among PWH than HIV-uninfected controls (p = .01). Nocturnal non-dipping of BP was significantly more common in PWH with normal clinic BP (p = .048). Clinical correlates of nocturnal non-dipping were similar in PWH and HIV-uninfected adults and included higher BMI, higher CD4(+) cell count, and high C-reactive protein for HR and markers of renal disease for BP. In conclusion, nocturnal non-dipping of both BP and HR was more common in PWH but further research is needed to determine causes and consequences of this difference.

Nolan, C., Reis, K., Fadhil, S., Etyang, A., Ezeomah, C., Kingery, J. R., Desderius, B., Lee, M. H., Kapiga, S., Peck, R. N.

Pages:1452-1456, Volume:23, Edition:6/4/2021, Date,Jul


Notes:Nolan, Cody|Reis, Karl|Fadhil, Salama|Etyang, Anthony|Ezeomah, Chiomah|Kingery, Justin R|Desderius, Bernard|Lee, Myung-Hee|Kapiga, Saidi|Peck, Robert N|eng|K01 TW010281/TW/FIC NIH HHS/|K01TW010281/TW/FIC NIH HHS/|Research Support, N.I.H., Extramural|2021/06/04 06:00|J Clin Hypertens (Greenwich). 2021 Jul;23(7):1452-1456. doi: 10.1111/jch.14300. Epub 2021 Jun 2.

ISBN: 1751-7176 (Electronic)|1524-6175 (Linking) Permanent ID: PMC8678662 Accession Number: 34080288

Author Address: Center for Global Health, Weill Cornell Medicine, New York, NY, USA.|Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA.|Mwanza Interventional Trials Unit (MITU), Mwanza, Tanzania.|Weill Bugando School of Medicine, Mwanza, Tanzania.|KEMRI-Wellcome Trust Research Program, Kilifi, Kenya.|Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.|Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.