Mortality during and following hospital admission among school-aged children: a cohort study


Wellcome Open Res

Background: Far less is known about the reasons for hospitalization or mortality during and after hospitalization among school-aged children than among under-fives in low- and middle-income countries. This study aimed to describe common types of illness causing hospitalisation; inpatient mortality and post-discharge mortality among school-age children at Kilifi County Hospital (KCH), Kenya. Methods: A retrospective cohort study of children 5-12 years old admitted at KCH, 2007 to 2016, and resident within the Kilifi Health Demographic Surveillance System (KHDSS). Children discharged alive were followed up for one year by quarterly census. Outcomes were inpatient and one-year post-discharge mortality. Results: We included 3,907 admissions among 3,196 children with a median age of 7 years 8 months (IQR 74-116 months). Severe anaemia (792, 20%), malaria (749, 19%), sickle cell disease (408, 10%), trauma (408, 10%), and severe pneumonia (340, 8.7%) were the commonest reasons for admission. Comorbidities included 623 (16%) with severe wasting, 386 (10%) with severe stunting, 90 (2.3%) with oedematous malnutrition and 194 (5.0%) with HIV infection. 132 (3.4%) children died during hospitalisation. Inpatient death was associated with signs of disease severity, age, bacteraemia, HIV infection and severe stunting. After discharge, 89/2,997 (3.0%) children died within one year during 2,853 child-years observed (31.2 deaths [95%CI, 25.3-38.4] per 1,000 child-years). 63/89 (71%) of post-discharge deaths occurred within three months and 45% of deaths occurred outside hospital. Post-discharge mortality was positively associated with weak pulse, tachypnoea, severe anaemia, HIV infection and severe wasting and negatively associated with malaria. Conclusions: Reasons for admissions are markedly different from those reported in under-fives. There was significant post-discharge mortality, suggesting hospitalisation is a marker of risk in this population. Our findings inform guideline development to include risk stratification, targeted post-discharge care and facilitate access to healthcare to improve survival in the early months post-discharge in school-aged children.

Ngari, M. M., Obiero, C., Mwangome, M. K., Nyaguara, A., Mturi, N., Murunga, S., Otiende, M., Iversen, P. O., Fegan, G. W., Walson, J. L., Berkley, J. A.

Pages:234, Volume:5, Edition:1/15/2021, Date,


Notes:Ngari, Moses M|Obiero, Christina|Mwangome, Martha K|Nyaguara, Amek|Mturi, Neema|Murunga, Sheila|Otiende, Mark|Iversen, Per Ole|Fegan, Gregory W|Walson, Judd L|Berkley, James A|eng|WT_/Wellcome Trust/United Kingdom|MR/M007367/1/MRC_/Medical Research Council/United Kingdom|England|2021/01/15 06:00|Wellcome Open Res. 2021 Jan 4;5:234. doi: 10.12688/wellcomeopenres.16323.2. eCollection 2020.

ISBN: 2398-502X (Print)|2398-502X (Linking) Permanent ID: PMC7656274.2 Accession Number: 33195820

Author Address: KEMRI/Wellcome Trust Research Programme, P.O Box 230 – 80108, Kilifi, Kenya.|The Childhood Acute Illness & Nutrition Network (CHAIN), Nairobi, Kenya.|Department of Nutrition, IBM, University of Oslo, Oslo, Norway.|Department of Haematology, Oslo University Hospital, Oslo, Norway.|Division of Human Nutrition, Stellenbosch University, Tygerberg, South Africa.|Swansea Trials Unit, Swansea University Medical School, Swansea, UK.|Departments of Global Health, Medicine, Pediatrics and Epidemiology, University of Washington, Seattle, Seattle, USA.|Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, UK.