0709 203000 - Nairobi 0709 983000 - Kilifi
0709 203000 - NRB 0709 983000 - Kilifi
0709 203000 - NRB | 0709 983000 - Kilifi

Management

Bio

Isabella Oyier is the Head of the Biosciences Department at KEMRI-Wellcome Trust Research Program (KWTRP), a Professor of Molecular Epidemiology, Nuffield Department of Medicine, University of Oxford a Calestous Juma Fellow, funded by BMGF and a Global Research Fellow at Reuben College, University of Oxford. Her current research focuses on integrating malaria molecular epidemiology into routine surveillance in Kenya. A project that partners with the Division of National Malaria Programme to implement malaria molecular surveillance activities. During the COVID-19 pandemic, she led the COVID-19 testing for the Coastal region. KWTRP was a regional COVID-19 genomic surveillance reference lab for Africa CDC and WHO-Afro and she led and coordinated this effort. In addition, she is coordinating the scale up COVID-19 immunological surveillance in the East Africa region, to determine genetic variants with immune escape potential. More recently she is co-leading a Wellcome funded 4 pathogen genomics surveillance grant that cuts across 8 countries, Cambodia, Indonesia, Kenya, Laos, Malawi, South Africa, Thailand and Vietnam.

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Current Work

Her research interests are in Plasmodium falciparum malaria molecular epidemiology, focusing on the spatial and temporal use of molecular tools to: 1) examine genetic variation in merozoite antigens that are potential candidates for blood stage vaccines and its impact on naturally acquired immunity; 2) define complexity of infection while examining the impact of interventions or changes in malaria epidemiology; 3) distinguish persistent infections and reinfections in both therapeutic efficacy studies and in longitudinal follow up of asymptomatic individuals; and 4) monitor drug resistance molecular markers.

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Recent publications

Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21.
Lucinde, R. K., Mugo, D., Bottomley, C., Karani, A., Gardiner, E., Aziza, R., Gitonga, J. N., Karanja, H., Nyagwange, J., Tuju, J., Wanjiku, P., Nzomo, E., Kamuri, E., Thuranira, K., Agunda, S., Nyutu, G., Etyang, A. O., Adetifa, I. M. O., Kagucia, E., Uyoga, S., Otiende, M., Otieno, E., Ndwiga, L., Agoti, C. N., Aman, R. A., Mwangangi, M., Amoth, P., Kasera, K., Nyaguara, A., Ng'ang'a, W., Ochola, L. B., Namdala, E., Gaunya, O., Okuku, R., Barasa, E., Bejon, P., Tsofa, B., Ochola-Oyier, L. I., Warimwe, G. M., Agweyu, A., Scott, J. A. G., Gallagher, K. E.
PLoS One, (2022). 17:e0265478

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.
Tegally, H., San, J. E., Cotten, M., Moir, M., Tegomoh, B., Mboowa, G., Martin, D. P., Baxter, C., Lambisia, A. W., Diallo, A., Amoako, D. G., Diagne, M. M., Sisay, A., Zekri, A. N., Gueye, A. S., Sangare, A. K., Ouedraogo, A. S., Sow, A., Musa, A. O., Sesay, A. K., Abias, A. G., Elzagheid, A. I., Lagare, A., Kemi, A. S., Abar, A. E., Johnson, A. A., Fowotade, A., Oluwapelumi, A. O., Amuri, A. A., Juru, A., Kandeil, A., Mostafa, A., Rebai, A., Sayed, A., Kazeem, A., Balde, A., Christoffels, A., Trotter, A. J., Campbell, A., Keita, A. K., Kone, A., Bouzid, A., Souissi, A., Agweyu, A., Naguib, A., Gutierrez, A. V., Nkeshimana, A., Page, A. J., Yadouleton, A., Vinze, A., Happi, A. N., Chouikha, A., Iranzadeh, A., Maharaj, A., Batchi-Bouyou, A. L., Ismail, A., Sylverken, A. A., Goba, A., Femi, A., Sijuwola, A. E., Marycelin, B., Salako, B. L., Oderinde, B. S., Bolajoko, B., Diarra, B., Herring, B. L., Tsofa, B., Lekana-Douki, B., Mvula, B., Njanpop-Lafourcade, B. M., Marondera, B. T., Khaireh, B. A., Kouriba, B., Adu, B., Pool, B., McInnis, B., Brook, C., Williamson, C., Nduwimana, C., Anscombe, C., Pratt, C. B., Scheepers, C., Akoua-Koffi, C. G., Agoti, C. N., Mapanguy, C. M., Loucoubar, C., Onwuamah, C. K., Ihekweazu, C., Malaka, C. N., Peyrefitte, C., Grace, C., Omoruyi, C. E., Rafai, C. D., Morang'a, C. M., Erameh, C., Lule, D. B., Bridges, D. J., Mukadi-Bamuleka, D., Park, D., Rasmussen, D. A., Baker, D., Nokes, D. J., Ssemwanga, D., Tshiabuila, D., Amuzu, D. S. Y., Goedhals, D., Grant, D. S., Omuoyo, D. O., Maruapula, D., Wanjohi, D. W., Foster-Nyarko, E., Lusamaki, E. K., Simulundu, E., Ong'era, E. M., Ngabana, E. N., Abworo, E. O., Otieno, E., Shumba, E., Barasa, E., Ahmed, E. B., Ahmed, E. A., Lokilo, E., Mukantwari, E., Philomena, E., Belarbi, E., Simon-Loriere, E., Anoh, E. A., Manuel, E., Leendertz, F., Taweh, F. M., Wasfi, F., Abdelmoula, F., Takawira, F. T., Derrar, F., Ajogbasile, F. V., Treurnicht, F., Onikepe, F., Ntoumi, F., Muyembe, F. M., Ragomzingba, F. E. Z., Dratibi, F. A., Iyanu, F. A., Mbunsu, G. K., Thilliez, G., Kay, G. L., Akpede, G. O., van Zyl, G. U., Awandare, G. A., Kpeli, G. S., Schubert, G., Maphalala, G. P., Ranaivoson, H. C., Omunakwe, H. E., Onywera, H., Abe, H., Karray, H., Nansumba, H., Triki, H., Kadjo, H. A. A., Elgahzaly, H., Gumbo, H., Mathieu, H., Kavunga-Membo, H., Smeti, I., Olawoye, I. B., Adetifa, I. M. O., Odia, I., Ben Boubaker, I. B., Mohammad, I. A., Ssewanyana, I., Wurie, I., Konstantinus, I. S., Halatoko, J. W. A., Ayei, J., Sonoo, J., Makangara, J. C., Tamfum, J. M., Heraud, J. M., Shaffer, J. G., Giandhari, J., Musyoki, J., Nkurunziza, J., Uwanibe, J. N., Bhiman, J. N., Yasuda, J., Morais, J., Kiconco, J., Sandi, J. D., Huddleston, J., Odoom, J. K., Morobe, J. M., Gyapong, J. O., Kayiwa, J. T., Okolie, J. C., Xavier, J. S., Gyamfi, J., Wamala, J. F., Bonney, J. H. K., Nyandwi, J., Everatt, J., Nakaseegu, J., Ngoi, J. M., Namulondo, J., Oguzie, J. U., Andeko, J. C., Lutwama, J. J., Mogga, J. J. H., O'Grady, J., Siddle, K. J., Victoir, K., Adeyemi, K. T., Tumedi, K. A., Carvalho, K. S., Mohammed, K. S., Dellagi, K., Musonda, K. G., Duedu, K. O., Fki-Berrajah, L., Singh, L., Kepler, L. M., Biscornet, L., de Oliveira Martins, L., Chabuka, L., Olubayo, L., Ojok, L. D., Deng, L. L., Ochola-Oyier, L. I., Tyers, L., Mine, M., Ramuth, M., Mastouri, M., ElHefnawi, M., Mbanne, M., Matsheka, M. I., Kebabonye, M., Diop, M., Momoh, M., Lima Mendonca, M. D. L., Venter, M., Paye, M. F., Faye, M., Nyaga, M. M., Mareka, M., Damaris, M. M., Mburu, M. W., Mpina, M. G., Owusu, M., Wiley, M. R., Tatfeng, M. Y., Ayekaba, M. O., Abouelhoda, M., Beloufa, M. A., Seadawy, M. G., Khalifa, M. K., Matobo, M. M., Kane, M., Salou, M., Mbulawa, M. B., Mwenda, M., Allam, M., Phan, M. V. T., Abid, N., Rujeni, N., Abuzaid, N., Ismael, N., Elguindy, N., Top, N. M., Dia, N., Mabunda, N., Hsiao, N. Y., Silochi, N. B., Francisco, N. M., Saasa, N., Bbosa, N., Murunga, N., Gumede, N., Wolter, N., Sitharam, N., Ndodo, N., Ajayi, N. A., Tordo, N., Mbhele, N., Razanajatovo, N. H., Iguosadolo, N., Mba, N., Kingsley, O. C., Sylvanus, O., Femi, O., Adewumi, O. M., Testimony, O., Ogunsanya, O. A., Fakayode, O., Ogah, O. E., Oludayo, O. E., Faye, O., Smith-Lawrence, P., Ondoa, P., Combe, P., Nabisubi, P., Semanda, P., Oluniyi, P. E., Arnaldo, P., Quashie, P. K., Okokhere, P. O., Bejon, P., Dussart, P., Bester, P. A., Mbala, P. K., Kaleebu, P., Abechi, P., El-Shesheny, R., Joseph, R., Aziz, R. K., Essomba, R. G., Ayivor-Djanie, R., Njouom, R., Phillips, R. O., Gorman, R., Kingsley, R. A., Neto Rodrigues, R. M. D. E. S. A., Audu, R. A., Carr, R. A. A., Gargouri, S., Masmoudi, S., Bootsma, S., Sankhe, S., Mohamed, S. I., Femi, S., Mhalla, S., Hosch, S., Kassim, S. K., Metha, S., Trabelsi, S., Agwa, S. H., Mwangi, S. W., Doumbia, S., Makiala-Mandanda, S., Aryeetey, S., Ahmed, S. S., Ahmed, S. M., Elhamoumi, S., Moyo, S., Lutucuta, S., Gaseitsiwe, S., Jalloh, S., Andriamandimby, S. F., Oguntope, S., Grayo, S., Lekana-Douki, S., Prosolek, S., Ouangraoua, S., van Wyk, S., Schaffner, S. F., Kanyerezi, S., Ahuka-Mundeke, S., Rudder, S., Pillay, S., Nabadda, S., Behillil, S., Budiaki, S. L., van der Werf, S., Mashe, T., Mohale, T., Le-Viet, T., Velavan, T. P., Schindler, T., Maponga, T. G., Bedford, T., Anyaneji, U. J., Chinedu, U., Ramphal, U., George, U. E., Enouf, V., Nene, V., Gorova, V., Roshdy, W. H., Karim, W. A., Ampofo, W. K., Preiser, W., Choga, W. T., Ahmed, Y. A., Ramphal, Y., Bediako, Y., Naidoo, Y., Butera, Y., de Laurent, Z. R., Africa Pathogen Genomics, Initiative., Ouma, A. E. O., von Gottberg, A., Githinji, G., Moeti, M., Tomori, O., Sabeti, P. C., Sall, A. A., Oyola, S. O., Tebeje, Y. K., Tessema, S. K., de Oliveira, T., Happi, C., Lessells, R., Nkengasong, J., Wilkinson, E.
Science, (2022). :eabq5358

Epidemiological impact and cost-effectiveness analysis of COVID-19 vaccination in Kenya.
Orangi, S., Ojal, J., Brand, S. P., Orlendo, C., Kairu, A., Aziza, R., Ogero, M., Agweyu, A., Warimwe, G. M., Uyoga, S., Otieno, E., Ochola-Oyier, L. I., Agoti, C. N., Kasera, K., Amoth, P., Mwangangi, M., Aman, R., Ng'ang'a, W., Adetifa, I. M., Scott, J. A. G., Bejon, P., Keeling, M. J., Flasche, S., Nokes, D. J., Barasa, E.
BMJ Glob Health, (2022). 7:e009430

Genomic Epidemiology of SARS-CoV-2 in Seychelles, 2020-2021.
Morobe, J. M., Pool, B., Marie, L., Didon, D., Lambisia, A. W., Makori, T., Mohammed, K. S., de Laurent, Z. R., Ndwiga, L., Mburu, M. W., Moraa, E., Murunga, N., Musyoki, J., Mwacharo, J., Nyamako, L., Riako, D., Ephnatus, P., Gambo, F., Naimani, J., Namulondo, J., Tembo, S. Z., Ogendi, E., Balde, T., Dratibi, F. A., Yahaya, A. A., Gumede, N., Achilla, R. A., Borus, P. K., Wanjohi, D. W., Tessema, S. K., Mwangangi, J., Bejon, P., Nokes, D. J., Ochola-Oyier, L. I., Githinji, G., Biscornet, L., Agoti, C. N.
Viruses, (2022). 14:1318

Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study.
Agoti, C. N., Ochola-Oyier, L. I., Dellicour, S., Mohammed, K. S., Lambisia, A. W., de Laurent, Z. R., Morobe, J. M., Mburu, M. W., Omuoyo, D. O., Ongera, E. M., Ndwiga, L., Maitha, E., Kitole, B., Suleiman, T., Mwakinangu, M., Nyambu, J. K., Otieno, J., Salim, B., Musyoki, J., Murunga, N., Otieno, E., Kiiru, J. N., Kasera, K., Amoth, P., Mwangangi, M., Aman, R., Kinyanjui, S., Warimwe, G., Phan, M., Agweyu, A., Cotten, M., Barasa, E., Tsofa, B., Nokes, D. J., Bejon, P., Githinji, G.
Elife, (2022). 11:e71703