A complete list of publications by Prof. Isabella Oyier. Use the filters to refine by year, journal or keyword.

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1. 2026
   Widespread variants of the highly polymorphic Plasmodium falciparum vaccine candidate antigen MSP2 across Sub-Saharan Africa

   Zerebinski, J. Broumou, I. Kimenyi, K. M. Aklillu, et al.

   J Infect Dis. 2026

   View abstract DOI PubMed
2. 2026
   Widespread variants of the highly polymorphic Plasmodium falciparum vaccine candidate antigen MSP2 across Sub-Saharan Africa

   Zerebinski, J. Broumou, I. Kimenyi, K. M. Aklillu, et al.

   J Infect Dis. 2026

   View abstract DOI PubMed
3. 2026
   Longitudinal Epidemiology and Variant Dynamics of SARS-CoV-2 in Coastal Kenya (2020-2025): Clinical Features and Wave Patterns

   Lambisia, A. W. Nyiro, J. Githinji, G. Katama, et al.

   Open Forum Infect Dis. 2026; 13:ofag084

   View abstract DOI PubMed
4. 2026
   Pre-COVID-19 ex vivo cross-reactive IFN-gamma cellular response to SARS-CoV-2 spike overlapping peptides is more prevalent among Kenyan compared to Swedish adults

   Wanjiku, P. Orindi, B. Mwacharo, J. Chemweno, et al.

   BMC Infect Dis. 2026; 26:174

   View abstract DOI PubMed
5. 2026
   Evolving patterns of antimalarial drug resistance markers in symptomatic infections in Kenya, 2013-2022

   Magudha, J. Ndwiga, L. Akinyi, M. Y. Wamae, et al.

   Parasit Vectors. 2026; 19

   View abstract DOI PubMed
6. 2026
   Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial

   Kapulu, M. C. Orenge, F. Kimani, D. Kibwana, et al.

   Nat Med. 2026; 32:178-185

   View abstract DOI PubMed
7. 2025
   Stable Plasmodium falciparum merozoite surface protein-1 allelic diversity despite decreasing parasitaemia in children with multiple malaria infections

   Yaa, R. M. Kimenyi, K. M. Palasciano, H. A. Obiero, et al.

   Malar J. 2025; 24:136

   View abstract DOI PubMed
8. 2025
   Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants' Full-Length Spikes in a Multiplex Luminex Assay

   Waweru, G. Nyakundi, R. Kutima, B. Owuor, et al.

   Viruses. 2025; 17

   View abstract DOI PubMed
9. 2025
   Induction of an early IFN-gamma cellular response and high plasma levels of SDF-1alpha are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients

   Wanjiku, P. Orindi, B. Kimotho, J. Sayed, et al.

   PLoS One. 2025; 20:e0316967

   View abstract DOI PubMed
10. 2025
    A scoping review of antimalarial drug resistance markers in Kenya (1987-2022): toward a National Surveillance Framework and Data Repository

    Wamae, K. Magudha, J. Asiimwe, E. Kimani, et al.

    Malar J. 2025; 24:413

    View abstract DOI PubMed
11. 2025
    Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya

    Osoti, V. Wamae, K. Ndwiga, L. Gichuki, et al.

    BMC Infect Dis. 2025; 25:73

    View abstract DOI PubMed
12. 2025
    Serial cross-sectional school surveys identifies C469Y, P553L, R561H and A675V kelch 13 mutations associated with artemisinin resistance in Western Kenya

    Osoti, V. Wamae, K. Musau, M. M. Magudha, et al.

    Sci Rep. 2025; 15:38303

    View abstract DOI PubMed
13. 2025
    The genome sequence of varicella-zoster virus (Varicellovirus humanalpha3) obtained by metagenomics from a patient presenting with an exanthem rash

    Musundi, S. Okanda, D. Lambisia, A. Morobe, et al.

    Microbiol Resour Announc. 2025; 14:e0024825

    View abstract DOI PubMed
14. 2025
    Emergence and transmission dynamics of the FY.4 Omicron variant in Kenya

    Musundi, S. Mwanga, M. Lambisia, A. Morobe, et al.

    Virus Evol. 2025; 11:veaf035

    View abstract DOI PubMed
15. 2025
    Regional action needed to halt antimalarial drug resistance in Africa

    Martinez-Vega, R. Ishengoma, D. S. Gosling, R. Rosenthal, et al.

    Lancet. 2025; 405:7-10

    View abstract DOI PubMed
16. 2025
    Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples

    Malaria Genomic Epidemiology, Network Abdel Hamid, M. M. Abdelraheem, M. H. Acheampong, et al.

    Wellcome Open Res. 2025; 10:325

    View abstract DOI PubMed
17. 2022
    A pragmatic randomized controlled trial of standard care versus corticosteroids plus standard care for treatment of pneumonia in adults admitted to Kenyan hospitals (SONIA)

    Lucinde, R. Abdi, A. Orindi, B. Mwakio, et al.

    Wellcome Open Res. 2022; 7:269

    View abstract DOI PubMed
18. 2025
    Genomic and clinical epidemiology of SARS-CoV-2 in coastal Kenya: insights into variant circulation, reinfection, and multiple lineage importations during a post-pandemic wave

    Lambisia, A. W. Katama, E. N. Moraa, E. Mwita, et al.

    BMC Glob Public Health. 2025; 3:80

    View abstract DOI PubMed
19. 2025
    Rethinking the evidence on COVID-19 in Africa

    Bejon, P. Agweyu, A. Ochola-Oyier, L. I. Hamaluba, et al.

    Lancet Infect Dis. 2025; 25:e463-e471

    View abstract DOI PubMed
20. 2025
    Characterizing Plasmodium falciparum genetic diversity and complexity of infections in clinical malaria infections in Western and Coastal Kenya using the poly-alpha microsatellite marker

    Abade, N. A. Mgawe, C. Ndwiga, L. Kimenyi, et al.

    Malar J. 2025; 24:452

    View abstract DOI PubMed
21. 2024
    Editorial: Malaria molecular epidemiology current situation in Africa

    Tandoh, K. Z. Duah-Quashie, N. O. Raman, J. Ochola-Oyier, et al.

    Front Epidemiol. 2024; 4:1400612

    View abstract DOI PubMed
22. 2024
    A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda

    Ogwang, R. Osoti, V. Wamae, K. Ndwiga, et al.

    Antimicrob Agents Chemother. 2024; 68:e0157623

    View abstract DOI PubMed
23. 2024
    Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya

    Lugano, D. Kutima, B. Kimani, M. Sigilai, et al.

    BMC Infect Dis. 2024; 24:1474

    View abstract DOI PubMed
24. 2024
    The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria

    Kioko, M. Mwangi, S. Pance, A. Ochola-Oyier, et al.

    Sci Adv. 2024; 10:eadl2256

    View abstract DOI PubMed
25. 2024
    Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected

    Kimenyi, K. M. Akinyi, M. Y. Mwikali, K. Gilmore, et al.

    BMC Infect Dis. 2024; 24:140

    View abstract DOI PubMed
26. 2022
    A cross-sectional analysis identifies a low prevalence of Plasmodium ovale species infections in symptomatic and asymptomatic individuals in Kilifi county, Kenya

    Akinyi, M. Y. Chifwete, M. Ndwiga, L. Kimenyi, et al.

    Wellcome Open Res. 2022; 7:207

    View abstract DOI PubMed
27. 2024
    ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria

    Adegbola, A. J. Ndwiga, L. Wamae, K. Osoti, et al.

    Front Genet. 2024; 15:1470156

    View abstract DOI PubMed
28. 2023
    Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya

    Okanda, D. Ndwiga, L. Osoti, V. Achieng, et al.

    Front Epidemiol. 2023; 3:1083114

    View abstract DOI PubMed
29. 2023
    Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro

    Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.

    Int J Infect Dis. 2023; 127:11-16

    View abstract DOI PubMed
30. 2023
    Validation of saline, PBS and a locally produced VTM at varying storage conditions to detect the SARS-CoV-2 virus by qRT-PCR

    Ngetsa, C. Osoti, V. Okanda, D. Marura, et al.

    PLoS One. 2023; 18:e0280685

    View abstract DOI PubMed
31. 2023
    New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March-May 2023

    Mwanga, M. J. Lambisia, A. W. Morobe, J. M. Murunga, et al.

    Emerg Infect Dis. 2023; 29:2376-2379

    View abstract DOI PubMed
32. 2023
    Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

    MalariaGen, Abdel Hamid, M. M. Abdelraheem, M. H. Acheampong, et al.

    Wellcome Open Res. 2023; 8:22

    View abstract DOI PubMed
33. 2023
    Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum

    Kioko, M. Pance, A. Mwangi, S. Goulding, et al.

    Nat Commun. 2023; 14:6447

    View abstract DOI PubMed
34. 2023
    SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022

    Kagucia, E. W. Ziraba, A. K. Nyagwange, J. Kutima, et al.

    Influenza Other Respir Viruses. 2023; 17:e13173

    View abstract DOI PubMed
35. 2023
    Symptom prevalence and secondary attack rate of SARS-CoV-2 in rural Kenyan households: A prospective cohort study

    Gallagher, K. E. Nyiro, J. Agoti, C. N. Maitha, et al.

    Influenza Other Respir Viruses. 2023; 17:e13185

    View abstract DOI PubMed
36. 2022
    Amplicon Sequencing as a Potential Surveillance Tool for Complexity of Infection and Drug Resistance Markers in Plasmodium falciparum Asymptomatic Infections

    Wamae, K. Kimenyi, K. M. Osoti, V. de Laurent, et al.

    J Infect Dis. 2022; 226:920-927

    View abstract DOI PubMed
37. 2022
    The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

    Tegally, H. San, J. E. Cotten, M. Moir, et al.

    Science. 2022; 378:eabq5358

    View abstract DOI PubMed
38. 2022
    Targeted Amplicon Deep Sequencing for Monitoring Antimalarial Resistance Markers in Western Kenya

    Osoti, V. Akinyi, M. Wamae, K. Kimenyi, et al.

    Antimicrob Agents Chemother. 2022; 66:e0194521

    View abstract DOI PubMed
39. 2022
    Epidemiological impact and cost-effectiveness analysis of COVID-19 vaccination in Kenya

    Orangi, S. Ojal, J. Brand, S. P. Orlendo, et al.

    BMJ Glob Health. 2022; 7

    View abstract DOI PubMed
40. 2022
    Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data

    Ojal, J. Brand, S. P. C. Were, V. Okiro, et al.

    Wellcome Open Res. 2022; 6:127

    View abstract DOI PubMed
41. 2022
    Epidemiology of COVID-19 infections on routine polymerase chain reaction (PCR) and serology testing in Coastal Kenya

    Nyagwange, J. Ndwiga, L. Muteru, K. Wamae, et al.

    Wellcome Open Res. 2022; 7:69

    View abstract DOI PubMed
42. 2022
    Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations

    Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.

    J Clin Virol. 2022; 146:105061

    View abstract DOI PubMed
43. 2022
    Genomic Epidemiology of SARS-CoV-2 in Seychelles, 2020-2021

    Morobe, J. M. Pool, B. Marie, L. Didon, et al.

    Viruses. 2022; 14

    View abstract DOI PubMed
44. 2022
    Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21

    Lucinde, R. K. Mugo, D. Bottomley, C. Karani, et al.

    PLoS One. 2022; 17:e0265478

    View abstract DOI PubMed
45. 2022
    Optimization of the SARS-CoV-2 ARTIC Network V4 Primers and Whole Genome Sequencing Protocol

    Lambisia, A. W. Mohammed, K. S. Makori, T. O. Ndwiga, et al.

    Front Med (Lausanne). 2022; 9:836728

    View abstract DOI PubMed
46. 2022
    Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018

    Kimenyi, K. M. Wamae, K. Ngoi, J. M. de Laurent, et al.

    Malar J. 2022; 21:192

    View abstract DOI PubMed
47. 2022
    Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya

    Etyang, A. O. Lucinde, R. Karanja, H. Kalu, et al.

    Clin Infect Dis. 2022; 74:288-293

    View abstract DOI PubMed
48. 2022
    SARS-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021

    Etyang, A. O. Adetifa, I. Omore, R. Misore, et al.

    PLOS Glob Public Health. 2022; 2:e0000883

    View abstract DOI PubMed
49. 2022
    Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study

    Agoti, C. N. Ochola-Oyier, L. I. Dellicour, S. Mohammed, et al.

    Elife. 2022; 11

    View abstract DOI PubMed
50. 2021
    Prevalence of anti-SARS-CoV-2 IgG antibodies among Kenyan blood donors between June and August 2021.

    Uyoga, S. Otiende, M. Adetifa, I. M. O. Karanja, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

    View abstract
51. 2021
    Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors

    Uyoga, S. Adetifa, I. M. O. Karanja, H. K. Nyagwange, et al.

    Science. 2021; 371:79-82

    View abstract DOI PubMed
52. 2021
    Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations.

    Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

    View abstract
53. 2021
    The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations

    Ndwiga, L. Osoti, V. Ochwedo, K. O. Wamae, et al.

    Malar J. 2021; 20:278

    View abstract DOI PubMed
54. 2021
    A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

    Ndwiga, L. Kimenyi, K. M. Wamae, K. Osoti, et al.

    Int J Parasitol Drugs Drug Resist. 2021; 16:155-161

    View abstract DOI PubMed
55. 2021
    An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

    MalariaGen, Ahouidi, A. Ali, M. Almagro-Garcia, et al.

    Wellcome Open Res. 2021; 6:42

    View abstract DOI PubMed
56. 2021
    Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya

    Kagucia, E. W. Gitonga, J. N. Kalu, C. Ochomo, et al.

    Open Forum Infect Dis. 2021; 8:ofab314

    View abstract DOI PubMed
57. 2021
    High anti-SARS-CoV-2 IgG antibody seroprevalence among long-distance trucking crews in Kenya within one year of the COVID-19 pandemic.

    Kagucia, E. W. Gitonga, J. N. Kalu, C. Kuya, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

    View abstract
58. 2021
    Genomic surveillance of SARS-CoV-2 in Kenya: March 2020-October 2021.

    Githinji, G. Lambisia, W. A. Mohamed, K. S. Morobe, et al.

    1st International Conference on Public Health in Africa (CPHIA-2021). 2021

    View abstract
59. 2021
    Tracking the introduction and spread of SARS-CoV-2 in coastal Kenya

    Githinji, G. de Laurent, Z. R. Mohammed, K. S. Omuoyo, et al.

    Nat Commun. 2021; 12:4809

    View abstract DOI PubMed
60. 2021
    Serosurveillance for SARS-CoV-2 Antibodies in a cohort of Health Care Workers in Kenya.

    Etyang, A. O. Lucinde, R. Gitonga, J. N. Kalu, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

    View abstract
61. 2021
    COVID-19 transmission dynamics underlying epidemic waves in Kenya

    Brand, S. P. C. Ojal, J. Aziza, R. Were, et al.

    Science. 2021; 374:989-994

    View abstract DOI PubMed
62. 2021
    Characteristics of SARS-CoV-2 infections in households in rural coastal Kenya: a prospective genomic study.

    Agoti, C.N. Nyiro, J. Murunga, N. Lambisia, et al.

    1st International Conference on Public Health in Africa (CPHIA-2021). 2021

    View abstract
63. 2021
    Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

    Adetifa, I. M. O. Uyoga, S. Gitonga, J. N. Mugo, et al.

    Nat Commun. 2021; 12:3966

    View abstract DOI PubMed
64. 2020
    An optimization of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams

    Mohammed, K. S. de Laurent, Z. R. Omuoyo, D. O. Lewa, et al.

    Wellcome Open Res. 2020; 5:162

    View abstract DOI PubMed
65. 2020
    Pooled testing conserves SARS-CoV-2 laboratory resources and improves test turn-around time: experience on the Kenyan Coast

    Agoti, C. N. Mutunga, M. Lambisia, A. W. Kimani, et al.

    Wellcome Open Res. 2020; 5:186

    View abstract DOI PubMed
66. 2019
    Transmission and Age Impact the Risk of Developing Febrile Malaria in Children with Asymptomatic Plasmodium falciparum Parasitemia

    Wamae, K. Wambua, J. Nyangweso, G. Mwambingu, et al.

    J Infect Dis. 2019; 219:936-944

    View abstract DOI PubMed
67. 2019
    No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites

    Wamae, K. Okanda, D. Ndwiga, L. Osoti, et al.

    Antimicrob Agents Chemother. 2019; 63

    View abstract DOI PubMed
68. 2019
    Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection

    Ochola-Oyier, L. I. Wamae, K. Omedo, I. Ogola, et al.

    Infect Genet Evol. 2019; 69:235-245

    View abstract DOI PubMed
69. 2019
    Peripheral blood mononuclear cell transcriptomes reveal an over-representation of down-regulated genes associated with immunity in HIV-exposed uninfected infants

    Musimbi, Z. D. Rono, M. K. Otieno, J. R. Kibinge, et al.

    Sci Rep. 2019; 9:18124

    View abstract DOI PubMed
70. 2019
    Understanding P. falciparum Asymptomatic Infections: A Proposition for a Transcriptomic Approach

    Kimenyi, K. M. Wamae, K. Ochola-Oyier, L. I.

    Front Immunol. 2019; 10:2398

    View abstract DOI PubMed
71. 2019
    Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook

    Ghansah, A. Kamau, E. Amambua-Ngwa, A. Ishengoma, et al.

    Malar J. 2019; 18:324

    View abstract DOI PubMed
72. 2018
    Polymorphisms in the K13 Gene in Plasmodium falciparum from Different Malaria Transmission Areas of Kenya

    de Laurent, Z. R. Chebon, L. J. Ingasia, L. A. Akala, et al.

    Am J Trop Med Hyg. 2018; 98:1360-1366

    View abstract DOI PubMed
73. 2017
    Geographic-genetic analysis of Plasmodium falciparum parasite populations from surveys of primary school children in Western Kenya

    Omedo, I. Mogeni, P. Rockett, K. Kamau, et al.

    Wellcome Open Res. 2017; 2:29

    View abstract DOI PubMed
74. 2016
    Implications from predicted B-cell and T-cell epitopes of Plasmodium falciparum merozoite proteins EBA175-RII and Rh5

    Wamae, K. K. Ochola-Oyier, L. I.

    Bioinformation. 2016; 12:82-91

    View abstract DOI PubMed
75. 2016
    Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

    Ochola-Oyier, L. I. Okombo, J. Wagatua, N. Ochieng, et al.

    Malar J. 2016; 15:261

    View abstract DOI PubMed
76. 2015
    The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya

    Ochola-Oyier, L. I. Okombo, J. Mwai, L. Kiara, et al.

    Antimicrob Agents Chemother. 2015; 59:1770-5

    View abstract DOI PubMed
77. 2014
    Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

    Okombo, J. Kamau, A. W. Marsh, K. Sutherland, et al.

    Int J Parasitol Drugs Drug Resist. 2014; 4:152-63

    View abstract DOI PubMed
78. 2014
    Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes

    Kiboi, D. Irungu, B. Orwa, J. Kamau, et al.

    Exp Parasitol. 2014; 147:23-32

    View abstract DOI PubMed
79. 2013
    The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa

    Okombo, J. Zongo, I. Gadalla, N. Bousema, et al.

    Antimicrob Agents Chemother. 2013; 57:4595-8

    View abstract DOI PubMed
80. 2013
    Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses

    Okombo, J. Abdi, A. I. Kiara, S. M. Mwai, et al.

    Antimicrob Agents Chemother. 2013; 57:6196-204

    View abstract DOI PubMed