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Researcher
Dr. Sophie Uyoga
Ag Deputy Director CGMR-C
KEMRI | Wellcome Trust
Publications (85)
A complete list of publications by Dr. Sophie Uyoga. Use the filters to refine by year, journal or keyword.
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2026
Intravenous Artesunate in Artemisinin-Resistant Severe Malaria in Uganda
Maitland, K. Okao, M. Conrad, M. D. Etwop, et al.
N Engl J Med. 2026; 394:2380-2382
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2025
Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants' Full-Length Spikes in a Multiplex Luminex Assay
Waweru, G. Nyakundi, R. Kutima, B. Owuor, et al.
Viruses. 2025; 17
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2025
Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study
Kariuki, S. N. Gilchrist, J. J. Uyoga, S. Macharia, et al.
J Infect Dis. 2025; 231:e10-e16
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2025
Comparing HemoCue(R) and Quantitative Buffy Coat(R) and Coulter Counter-measured haemoglobin concentrations in African children with acute uncomplicated malaria: a Bland-Altman analysis
Ayuen, D. S. Olupot-Olupot, P. Muhindo, R. Onyamboko, et al.
Malar J. 2025; 24:77
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2025
Plasma folate dynamics in Plasmodium falciparum-infected African children treated with artemisinin combination therapy and single low-dose primaquine or placebo
Ajayi, S. Onyamboko, M. A. Olupot-Olupot, P. Ayuen, et al.
Malar J. 2025; 24:342
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2024
Comparative performance of the InBios SCoV-2 Detect (TM) IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations
Kutima, B. Kagucia, E. W. Mwai, K. Kimani, et al.
Wellcome Open Res. 2024; 9:349
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2024
Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial
Connon, R. Olupot-Olupot, P. Pistorius, A. M. A. Okiror, et al.
BMC Med. 2024; 22:516
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2023
Blood transfusion for children in sub-Saharan Africa: 200 years on
Uyoga, S. Mbanya, D. George, E. C. Maitland, et al.
Lancet Child Adolesc Health. 2023; 7:525-526
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2023
Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial
Taylor, W. R. Olupot-Olupot, P. Onyamboko, M. A. Peerawaranun, et al.
Lancet Infect Dis. 2023; 23:471-483
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2023
Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria
Opi, D. H. Ndila, C. M. Uyoga, S. Macharia, et al.
PLoS Genet. 2023; 19:e1010910
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2023
Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo
Onyamboko, M. A. Olupot-Olupot, P. Were, W. Namayanja, et al.
BMC Med. 2023; 21:397
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2021
Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial
Olupot-Olupot, P. Okiror, W. Mnjalla, H. Muhindo, et al.
Wellcome Open Res. 2021; 6:161
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2023
Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria
Mukaka, M. Onyamboko, M. A. Olupot-Olupot, P. Peerawaranun, et al.
EBioMedicine. 2023; 96:104805
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2023
SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022
Kagucia, E. W. Ziraba, A. K. Nyagwange, J. Kutima, et al.
Influenza Other Respir Viruses. 2023; 17:e13173
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2022
Substantial misdiagnosis of severe malaria in African children
White, N. J. Watson, J. A. Uyoga, S. Williams, et al.
Lancet. 2022; 400:807
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2022
Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations
Watson, J. A. Uyoga, S. Wanjiku, P. Makale, et al.
Sci Transl Med. 2022; 14:eabn5040
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2022
The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
Uyoga, S. Watson, J. A. Wanjiku, P. Rop, et al.
Nat Commun. 2022; 13:3307
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2022
Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT)
Uyoga, S. Olupot-Olupot, P. Connon, R. Kiguli, et al.
Lancet Child Adolesc Health. 2022; 6:606-613
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2022
Epidemiological impact and cost-effectiveness analysis of COVID-19 vaccination in Kenya
Orangi, S. Ojal, J. Brand, S. P. Orlendo, et al.
BMJ Glob Health. 2022; 7
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2022
A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa
Olupot-Olupot, P. Connon, R. Kiguli, S. Opoka, et al.
Am J Hematol. 2022; 97:527-536
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2022
Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data
Ojal, J. Brand, S. P. C. Were, V. Okiro, et al.
Wellcome Open Res. 2022; 6:127
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2022
A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era
Obonyo, N. G. Olupot-Olupot, P. Mpoya, A. Nteziyaremye, et al.
Pediatr Crit Care Med. 2022; 23:502-513
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2022
Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations
Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.
J Clin Virol. 2022; 146:105061
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2022
Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21
Lucinde, R. K. Mugo, D. Bottomley, C. Karani, et al.
PLoS One. 2022; 17:e0265478
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2022
High false discovery rate of the Architect anti-HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing
Lucey, O. Acana, S. Olupot-Olupot, P. Muhindo, et al.
Vox Sang. 2022; 117:1360-1367
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2022
BIRC6 modifies risk of invasive bacterial infection in Kenyan children
Gilchrist, J. J. Kariuki, S. N. Watson, J. A. Band, et al.
Elife. 2022; 11
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2022
Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial
George, E. C. Uyoga, S. M'Baya, B. Kyeyune Byabazair, et al.
Lancet Glob Health. 2022; 10:e360-e368
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2022
Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya
Etyang, A. O. Lucinde, R. Karanja, H. Kalu, et al.
Clin Infect Dis. 2022; 74:288-293
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2022
SARS-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021
Etyang, A. O. Adetifa, I. Omore, R. Misore, et al.
PLOS Glob Public Health. 2022; 2:e0000883
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2021
Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
Watson, J. A. Ndila, C. M. Uyoga, S. Macharia, et al.
Elife. 2021; 10
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2021
Plasma Plasmodium falciparum Histidine-rich Protein 2 Concentrations in Children With Malaria Infections of Differing Severity in Kilifi, Kenya
Uyoga, S. Wanjiku, P. Rop, J. C. Makale, et al.
Clin Infect Dis. 2021; 73:e2415-e2423
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2021
Prevalence of anti-SARS-CoV-2 IgG antibodies among Kenyan blood donors between June and August 2021.
Uyoga, S. Otiende, M. Adetifa, I. M. O. Karanja, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Point-of-care haemoglobin testing in African hospitals: a neglected essential diagnostic test
Uyoga, S. George, E. C. Bates, I. Olupot-Olupot, et al.
Br J Haematol. 2021; 193:894-901
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2021
Prevalence of SARS-CoV-2 Antibodies From a National Serosurveillance of Kenyan Blood Donors, January-March 2021
Uyoga, S. Adetifa, I. M. O. Otiende, M. Yegon, et al.
JAMA. 2021; 326:1436-1438
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2021
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors
Uyoga, S. Adetifa, I. M. O. Karanja, H. K. Nyagwange, et al.
Science. 2021; 371:79-82
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2021
Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations.
Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Transfusion management of severe anaemia in African children: a consensus algorithm
Maitland, K. Kiguli, S. Olupot-Olupot, P. Opoka, et al.
Br J Haematol. 2021; 193:1247-1259
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2021
Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya
Kagucia, E. W. Gitonga, J. N. Kalu, C. Ochomo, et al.
Open Forum Infect Dis. 2021; 8:ofab314
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2021
High anti-SARS-CoV-2 IgG antibody seroprevalence among long-distance trucking crews in Kenya within one year of the COVID-19 pandemic.
Kagucia, E. W. Gitonga, J. N. Kalu, C. Kuya, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Serosurveillance for SARS-CoV-2 Antibodies in a cohort of Health Care Workers in Kenya.
Etyang, A. O. Lucinde, R. Gitonga, J. N. Kalu, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data
Connon, R. George, E. C. Olupot-Olupot, P. Kiguli, et al.
BMC Public Health. 2021; 21:1480
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2021
COVID-19 transmission dynamics underlying epidemic waves in Kenya
Brand, S. P. C. Ojal, J. Aziza, R. Were, et al.
Science. 2021; 374:989-994
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2021
Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels
Bottomley, C. Otiende, M. Uyoga, S. Gallagher, et al.
Nat Commun. 2021; 12:6196
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2021
Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya
Adetifa, I. M. O. Uyoga, S. Gitonga, J. N. Mugo, et al.
Nat Commun. 2021; 12:3966
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2020
Glucose-6-phosphate dehydrogenase deficiency and susceptibility to childhood diseases in Kilifi, Kenya
Uyoga, S. Macharia, A. W. Ndila, C. M. Nyutu, et al.
Blood Adv. 2020; 4:5942-5950
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2020
Caring for Africa's sickle cell children: will we rise to the challenge?
Oron, A. P. Chao, D. L. Ezeanolue, E. E. Ezenwa, et al.
BMC Med. 2020; 18:92
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2020
The clinical spectrum of severe childhood malaria in Eastern Uganda
Olupot-Olupot, P. Engoru, C. Nteziyaremye, J. Chebet, et al.
Malar J. 2020; 19:322
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2020
beta-Thalassemia pathogenic variants in a cohort of children from the East African coast
Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, et al.
Mol Genet Genomic Med. 2020; 8:e1294
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2020
Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency
Gilchrist, J. J. Uyoga, S. Pirinen, M. Rautanen, et al.
BMC Med. 2020; 18:148
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2019
Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa
Uyoga, S. Mpoya, A. Olupot-Olupot, P. Kiguli, et al.
Vox Sang. 2019; 114:340-348
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2019
The indirect health effects of malaria estimated from health advantages of the sickle cell trait
Uyoga, S. Macharia, A. W. Ndila, C. M. Nyutu, et al.
Nat Commun. 2019; 10:856
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2019
The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study
Uyoga, S. Macharia, A. W. Mochamah, G. Ndila, et al.
Lancet Glob Health. 2019; 7:e1458-e1466
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2019
Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial
Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.
Lancet Glob Health. 2019; 7:e1435-e1447
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2019
Transfusion Volume for Children with Severe Anemia in Africa
Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.
N Engl J Med. 2019; 381:420-431
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2019
Informing thresholds for paediatric transfusion in Africa: the need for a trial
Maitland, K. Ohuma, E. O. Mpoya, A. Uyoga, et al.
Wellcome Open Res. 2019; 4:27
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2019
Immediate Transfusion in African Children with Uncomplicated Severe Anemia
Maitland, K. Kiguli, S. Olupot-Olupot, P. Engoru, et al.
N Engl J Med. 2019; 381:407-419
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2019
The population dynamics of hemoglobins A, A(2), F and S in the context of the hemoglobinopathies HbS and alpha-thalassemia in Kenyan infants
Macharia, A. W. Uyoga, S. Ndila, C. Nyutu, et al.
Haematologica. 2019; 104:e184-e186
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2019
Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration
Houston, K. A. Gibb, J. Olupot-Olupot, P. Obonyo, et al.
BMC Med. 2019; 17:122
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2018
Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia
Opi, D. H. Swann, O. Macharia, A. Uyoga, et al.
Elife. 2018; 7
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2018
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Ndila, C. M. Uyoga, S. Macharia, A. W. Nyutu, et al.
Lancet Haematol. 2018; 5:e333-e345
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2018
The clinical epidemiology of sickle cell anemia In Africa
Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, et al.
Am J Hematol. 2018; 93:363-370
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2018
Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria
Kotlyar, S. Olupot-Olupot, P. Nteziyaremye, J. Akech, et al.
Pediatr Crit Care Med. 2018; 19:179-185
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2017
No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes
Swann, O. V. Harrison, E. M. Opi, D. H. Nyatichi, et al.
Sci Rep. 2017; 7:17825
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2017
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda
Olupot-Olupot, P. Engoru, C. Uyoga, S. Muhindo, et al.
Clin Infect Dis. 2017; 64:939-946
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2017
Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia
Clarke, G. M. Rockett, K. Kivinen, K. Hubbart, et al.
Elife. 2017; 6
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2016
Red blood cell complement receptor one level varies with Knops blood group, alpha(+)thalassaemia and age among Kenyan children
Opi, D. H. Uyoga, S. Orori, E. N. Williams, et al.
Genes Immun. 2016; 17:171-8
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2016
Environmental Correlation Analysis for Genes Associated with Protection against Malaria
Mackinnon, M. J. Ndila, C. Uyoga, S. Macharia, et al.
Mol Biol Evol. 2016; 33:1188-204
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2016
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children
Kenyan Bacteraemia Study, Group Wellcome Trust Case Control, Consortium Rautanen, A. Pirinen, et al.
Am J Hum Genet. 2016; 98:1092-1100
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2015
Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study
Uyoga, S. Ndila, C. M. Macharia, A. W. Nyutu, et al.
Lancet Haematol. 2015; 2:e437-44
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2015
Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models
Ndungu, F. M. Marsh, K. Fegan, G. Wambua, et al.
BMC Med. 2015; 13:183
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2015
Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial
Mpoya, A. Kiguli, S. Olupot-Olupot, P. Opoka, et al.
Trials. 2015; 16:593
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2014
Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya
Shah, S. S. Macharia, A. Makale, J. Uyoga, et al.
BMC Med Genet. 2014; 15:93
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2014
Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia
Olupot-Olupot, P. Engoru, C. Thompson, J. Nteziyaremye, et al.
BMC Med. 2014; 12:67
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2014
Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children
Atkinson, S. H. Armitage, A. E. Khandwala, S. Mwangi, et al.
Blood. 2014; 123:3221-9
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2012
Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia
Uyoga, S. Skorokhod, O. A. Opiyo, M. Orori, et al.
Br J Haematol. 2012; 157:116-24
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2011
Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
Scott, J. A. Berkley, J. A. Mwangi, I. Ochola, et al.
Lancet. 2011; 378:1316-23
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2010
Preventable deaths in sickle-cell anaemia in African children - Authors' reply
Williams, T.N. Uyoga, S. Macharia, A. Sharif, et al.
Lancet. 2010; 375:461
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2010
High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya
McAuley, C. F. Webb, C. Makani, J. Macharia, et al.
Blood. 2010; 116:1663-8
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2010
Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis
Idro, R. Gwer, S. Williams, T. N. Otieno, et al.
PLoS One. 2010; 5:e14001
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2009
Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study
Williams, T. N. Uyoga, S. Macharia, A. Ndila, et al.
Lancet. 2009; 374:1364-70
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2008
Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area
Idro, R. Williams, T. N. Gwer, S. Uyoga, et al.
Epilepsy Res. 2008; 81:114-8
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2007
Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa
Beeson, J. G. Ndungu, F. Persson, K. E. Chesson, et al.
Am J Trop Med Hyg. 2007; 77:22-8
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2006
Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters
Wambua, S. Mwacharo, J. Uyoga, S. Macharia, et al.
Br J Haematol. 2006; 133:206-9
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2005
Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
Williams, T. N. Wambua, S. Uyoga, S. Macharia, et al.
Blood. 2005; 106:368-71
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2005
Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait
Williams, T. N. Mwangi, T. W. Wambua, S. Peto, et al.
Nat Genet. 2005; 37:1253-7