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Management

Researcher

Dr. Sophie Uyoga

Ag Deputy Director CGMR-C

KEMRI | Wellcome Trust

Publications (85)

A complete list of publications by Dr. Sophie Uyoga. Use the filters to refine by year, journal or keyword.

  1. 2026
    Intravenous Artesunate in Artemisinin-Resistant Severe Malaria in Uganda

    Maitland, K. Okao, M. Conrad, M. D. Etwop, et al.

    N Engl J Med. 2026; 394:2380-2382

  2. 2025
  3. 2025
    Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study

    Kariuki, S. N. Gilchrist, J. J. Uyoga, S. Macharia, et al.

    J Infect Dis. 2025; 231:e10-e16

  4. 2025
  5. 2025
  6. 2024
  7. 2024
    Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial

    Connon, R. Olupot-Olupot, P. Pistorius, A. M. A. Okiror, et al.

    BMC Med. 2024; 22:516

  8. 2023
    Blood transfusion for children in sub-Saharan Africa: 200 years on

    Uyoga, S. Mbanya, D. George, E. C. Maitland, et al.

    Lancet Child Adolesc Health. 2023; 7:525-526

  9. 2023
  10. 2023
    Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria

    Opi, D. H. Ndila, C. M. Uyoga, S. Macharia, et al.

    PLoS Genet. 2023; 19:e1010910

  11. 2023
  12. 2021
  13. 2023
    Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria

    Mukaka, M. Onyamboko, M. A. Olupot-Olupot, P. Peerawaranun, et al.

    EBioMedicine. 2023; 96:104805

  14. 2023
  15. 2022
    Substantial misdiagnosis of severe malaria in African children

    White, N. J. Watson, J. A. Uyoga, S. Williams, et al.

    Lancet. 2022; 400:807

  16. 2022
    Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations

    Watson, J. A. Uyoga, S. Wanjiku, P. Makale, et al.

    Sci Transl Med. 2022; 14:eabn5040

  17. 2022
  18. 2022
    Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT)

    Uyoga, S. Olupot-Olupot, P. Connon, R. Kiguli, et al.

    Lancet Child Adolesc Health. 2022; 6:606-613

  19. 2022
    Epidemiological impact and cost-effectiveness analysis of COVID-19 vaccination in Kenya

    Orangi, S. Ojal, J. Brand, S. P. Orlendo, et al.

    BMJ Glob Health. 2022; 7

  20. 2022
  21. 2022
    Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data

    Ojal, J. Brand, S. P. C. Were, V. Okiro, et al.

    Wellcome Open Res. 2022; 6:127

  22. 2022
    A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era

    Obonyo, N. G. Olupot-Olupot, P. Mpoya, A. Nteziyaremye, et al.

    Pediatr Crit Care Med. 2022; 23:502-513

  23. 2022
  24. 2022
  25. 2022
  26. 2022
    BIRC6 modifies risk of invasive bacterial infection in Kenyan children

    Gilchrist, J. J. Kariuki, S. N. Watson, J. A. Band, et al.

    Elife. 2022; 11

  27. 2022
  28. 2022
    Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya

    Etyang, A. O. Lucinde, R. Karanja, H. Kalu, et al.

    Clin Infect Dis. 2022; 74:288-293

  29. 2022
    SARS-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021

    Etyang, A. O. Adetifa, I. Omore, R. Misore, et al.

    PLOS Glob Public Health. 2022; 2:e0000883

  30. 2021
    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    Watson, J. A. Ndila, C. M. Uyoga, S. Macharia, et al.

    Elife. 2021; 10

  31. 2021
  32. 2021
    Prevalence of anti-SARS-CoV-2 IgG antibodies among Kenyan blood donors between June and August 2021.

    Uyoga, S. Otiende, M. Adetifa, I. M. O. Karanja, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

  33. 2021
    Point-of-care haemoglobin testing in African hospitals: a neglected essential diagnostic test

    Uyoga, S. George, E. C. Bates, I. Olupot-Olupot, et al.

    Br J Haematol. 2021; 193:894-901

  34. 2021
    Prevalence of SARS-CoV-2 Antibodies From a National Serosurveillance of Kenyan Blood Donors, January-March 2021

    Uyoga, S. Adetifa, I. M. O. Otiende, M. Yegon, et al.

    JAMA. 2021; 326:1436-1438

  35. 2021
    Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors

    Uyoga, S. Adetifa, I. M. O. Karanja, H. K. Nyagwange, et al.

    Science. 2021; 371:79-82

  36. 2021
  37. 2021
    Transfusion management of severe anaemia in African children: a consensus algorithm

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Opoka, et al.

    Br J Haematol. 2021; 193:1247-1259

  38. 2021
    Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya

    Kagucia, E. W. Gitonga, J. N. Kalu, C. Ochomo, et al.

    Open Forum Infect Dis. 2021; 8:ofab314

  39. 2021
    High anti-SARS-CoV-2 IgG antibody seroprevalence among long-distance trucking crews in Kenya within one year of the COVID-19 pandemic.

    Kagucia, E. W. Gitonga, J. N. Kalu, C. Kuya, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

  40. 2021
    Serosurveillance for SARS-CoV-2 Antibodies in a cohort of Health Care Workers in Kenya.

    Etyang, A. O. Lucinde, R. Gitonga, J. N. Kalu, et al.

    1st International Conference on Public Health in Africa (CPHIA). 2021

  41. 2021
  42. 2021
    COVID-19 transmission dynamics underlying epidemic waves in Kenya

    Brand, S. P. C. Ojal, J. Aziza, R. Were, et al.

    Science. 2021; 374:989-994

  43. 2021
    Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels

    Bottomley, C. Otiende, M. Uyoga, S. Gallagher, et al.

    Nat Commun. 2021; 12:6196

  44. 2021
    Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

    Adetifa, I. M. O. Uyoga, S. Gitonga, J. N. Mugo, et al.

    Nat Commun. 2021; 12:3966

  45. 2020
    Glucose-6-phosphate dehydrogenase deficiency and susceptibility to childhood diseases in Kilifi, Kenya

    Uyoga, S. Macharia, A. W. Ndila, C. M. Nyutu, et al.

    Blood Adv. 2020; 4:5942-5950

  46. 2020
    Caring for Africa's sickle cell children: will we rise to the challenge?

    Oron, A. P. Chao, D. L. Ezeanolue, E. E. Ezenwa, et al.

    BMC Med. 2020; 18:92

  47. 2020
    The clinical spectrum of severe childhood malaria in Eastern Uganda

    Olupot-Olupot, P. Engoru, C. Nteziyaremye, J. Chebet, et al.

    Malar J. 2020; 19:322

  48. 2020
    beta-Thalassemia pathogenic variants in a cohort of children from the East African coast

    Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, et al.

    Mol Genet Genomic Med. 2020; 8:e1294

  49. 2020
    Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency

    Gilchrist, J. J. Uyoga, S. Pirinen, M. Rautanen, et al.

    BMC Med. 2020; 18:148

  50. 2019
    Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa

    Uyoga, S. Mpoya, A. Olupot-Olupot, P. Kiguli, et al.

    Vox Sang. 2019; 114:340-348

  51. 2019
    The indirect health effects of malaria estimated from health advantages of the sickle cell trait

    Uyoga, S. Macharia, A. W. Ndila, C. M. Nyutu, et al.

    Nat Commun. 2019; 10:856

  52. 2019
    The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study

    Uyoga, S. Macharia, A. W. Mochamah, G. Ndila, et al.

    Lancet Glob Health. 2019; 7:e1458-e1466

  53. 2019
  54. 2019
    Transfusion Volume for Children with Severe Anemia in Africa

    Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.

    N Engl J Med. 2019; 381:420-431

  55. 2019
    Informing thresholds for paediatric transfusion in Africa: the need for a trial

    Maitland, K. Ohuma, E. O. Mpoya, A. Uyoga, et al.

    Wellcome Open Res. 2019; 4:27

  56. 2019
    Immediate Transfusion in African Children with Uncomplicated Severe Anemia

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Engoru, et al.

    N Engl J Med. 2019; 381:407-419

  57. 2019
  58. 2019
  59. 2018
  60. 2018
    Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

    Ndila, C. M. Uyoga, S. Macharia, A. W. Nyutu, et al.

    Lancet Haematol. 2018; 5:e333-e345

  61. 2018
    The clinical epidemiology of sickle cell anemia In Africa

    Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, et al.

    Am J Hematol. 2018; 93:363-370

  62. 2018
    Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria

    Kotlyar, S. Olupot-Olupot, P. Nteziyaremye, J. Akech, et al.

    Pediatr Crit Care Med. 2018; 19:179-185

  63. 2017
    No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes

    Swann, O. V. Harrison, E. M. Opi, D. H. Nyatichi, et al.

    Sci Rep. 2017; 7:17825

  64. 2017
    High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda

    Olupot-Olupot, P. Engoru, C. Uyoga, S. Muhindo, et al.

    Clin Infect Dis. 2017; 64:939-946

  65. 2017
  66. 2016
  67. 2016
    Environmental Correlation Analysis for Genes Associated with Protection against Malaria

    Mackinnon, M. J. Ndila, C. Uyoga, S. Macharia, et al.

    Mol Biol Evol. 2016; 33:1188-204

  68. 2016
    Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

    Kenyan Bacteraemia Study, Group Wellcome Trust Case Control, Consortium Rautanen, A. Pirinen, et al.

    Am J Hum Genet. 2016; 98:1092-1100

  69. 2015
  70. 2015
  71. 2015
  72. 2014
    Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya

    Shah, S. S. Macharia, A. Makale, J. Uyoga, et al.

    BMC Med Genet. 2014; 15:93

  73. 2014
    Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

    Olupot-Olupot, P. Engoru, C. Thompson, J. Nteziyaremye, et al.

    BMC Med. 2014; 12:67

  74. 2014
  75. 2012
  76. 2011
  77. 2010
    Preventable deaths in sickle-cell anaemia in African children - Authors' reply

    Williams, T.N. Uyoga, S. Macharia, A. Sharif, et al.

    Lancet. 2010; 375:461

  78. 2010
    High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

    McAuley, C. F. Webb, C. Makani, J. Macharia, et al.

    Blood. 2010; 116:1663-8

  79. 2010
    Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis

    Idro, R. Gwer, S. Williams, T. N. Otieno, et al.

    PLoS One. 2010; 5:e14001

  80. 2009
    Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study

    Williams, T. N. Uyoga, S. Macharia, A. Ndila, et al.

    Lancet. 2009; 374:1364-70

  81. 2008
    Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area

    Idro, R. Williams, T. N. Gwer, S. Uyoga, et al.

    Epilepsy Res. 2008; 81:114-8

  82. 2007
    Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa

    Beeson, J. G. Ndungu, F. Persson, K. E. Chesson, et al.

    Am J Trop Med Hyg. 2007; 77:22-8

  83. 2006
    Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters

    Wambua, S. Mwacharo, J. Uyoga, S. Macharia, et al.

    Br J Haematol. 2006; 133:206-9

  84. 2005
  85. 2005
    Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait

    Williams, T. N. Mwangi, T. W. Wambua, S. Peto, et al.

    Nat Genet. 2005; 37:1253-7