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Researcher
Prof. Ambrose Agweyu
Deputy Director, Nairobi
KEMRI | Wellcome Trust
Publications (94)
A complete list of publications by Prof. Ambrose Agweyu. Use the filters to refine by year, journal or keyword.
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2026
Benchmarking large language models and clinicians using locally generated primary healthcare vignettes in Kenya
Mwaniki, P. Musau, W. Isaaka, L. Wanyama, et al.
BMJ Digit Health Ai. 2026; 2:e000081
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2026
Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance
Ombati, R. Kimani, M. Akech, D. Kutima, et al.
Sci Rep. 2026
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2026
Safety of a large language model-based clinical decision support system in African primary healthcare
Agweyu, A. Mwaniki, P. Musau, W. Korom, et al.
Nat Health. 2026; 1:607-618
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2026
Multimodal pulse oximeters to support the integrated management of childhood illnesses: A usability and diagnostic accuracy assessment from a multi-country hybrid type 2 study
Storey, H. L. Fielding, T. L. Mwesigwa, J. Green, et al.
PLOS Glob Public Health. 2026; 6:e0004655
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2025
Assessing the Impact of SARS-CoV-2 Spike Mutations on Antibody Binding: A Comparative Assessment of the Wuhan and JN.1 Variants' Full-Length Spikes in a Multiplex Luminex Assay
Waweru, G. Nyakundi, R. Kutima, B. Owuor, et al.
Viruses. 2025; 17
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2025
Countries should strengthen their health information systems
Strong, K. Abajobir, A. Aboud, F. Agweyu, et al.
BMJ. 2025; 389:r791
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2025
Perceived accuracy and utilisation of DHIS2 data for health decision making and advocacy in Kenya: A Qualitative Study
Oware, P. M. Omondi, G. Adipo, C. Adow, et al.
PLOS Glob Public Health. 2025; 5:e0004508
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2025
Active vaccine safety surveillance: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya
Odhiambo, D. B. Akech, D. Karia, B. Kimani, et al.
PLOS Glob Public Health. 2025; 5:e0005080
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2025
Trials for LLM-supported clinical decisions in African primary healthcare
Mateen, B. A. Menon, V. Agweyu, A. Korom, et al.
Nat Med. 2025; 31:2833-2835
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2025
A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia
Lucinde, R. K. Gathuri, H. Mwaniki, P. Orindi, et al.
N Engl J Med. 2025; 393:2187-2197
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2022
A pragmatic randomized controlled trial of standard care versus corticosteroids plus standard care for treatment of pneumonia in adults admitted to Kenyan hospitals (SONIA)
Lucinde, R. Abdi, A. Orindi, B. Mwakio, et al.
Wellcome Open Res. 2022; 7:269
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2025
Addressing the challenges of estimating the target population in calculation of routine infant immunization coverage in Kenya
Karanja-Chege, C. Agweyu, A. Were, F. Boele van Hensbroek, et al.
PLOS Glob Public Health. 2025; 5:e0004298
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2024
Profile: The Kenya Multi-Site Serosurveillance (KEMIS) collaboration
Kagucia, E. W. Voller, S. Ziraba, A. K. Bigogo, et al.
Gates Open Res. 2024; 8:60
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2025
Pilot implementation of short message service for randomisation in a multisite pragmatic factorial clinical trial in Kenya
Chepkirui, M. Kimego, D. Nzioki, C. Jowi, et al.
Pilot Feasibility Stud. 2025; 11:29
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2025
Uptake and determinants of routine immunization among vulnerable children and adolescents in sub-Saharan Africa: A scoping review
Chege, C. K. Karanja, S. Ogallo, W. Were, et al.
Vaccine. 2025; 54:127021
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2025
Predictors of HIV testing and status disclosure among young adolescents in postconflict settings: findings from a pre-post study design in Nimule per-urban town of South Sudan
Bojo, S. Kokwaro, G. Agweyu, A.
BMJ Open. 2025; 15:e094008
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2025
Evaluating the level of knowledge of HIV prevention methods and associated socio-demographic factors among adolescents before and after participating in health education in Nimule town of South Sudan
Bojo, S. Kokwaro, G. Agweyu, A.
BMC Public Health. 2025; 25:746
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2025
COVID-19 mortality in Africa and Asia - Authors' reply
Bejon, P. Agweyu, A. Oyier, I. Hamaluba, et al.
Lancet Infect Dis. 2025; 25:e440
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2025
Rethinking the evidence on COVID-19 in Africa
Bejon, P. Agweyu, A. Ochola-Oyier, L. I. Hamaluba, et al.
Lancet Infect Dis. 2025; 25:e463-e471
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2024
Recommendations for Using Health Service Coverage Cascades to Measure Effective Coverage for Maternal, Newborn, Child, and Adolescent Health Services or Interventions
Strong, K. Konstantinou, G. Agweyu, A. Diaz, et al.
Glob Health Sci Pract. 2024; 12
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2024
Latent viral infections as neglected risk factors for long COVID - Authors' reply
Muller, S. A. Isaaka, L. Mumm, R. Scheidt-Nave, et al.
Lancet Glob Health. 2024; 12:e198
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2024
Implementing adaptive e-learning for newborn care in Tanzania: an observational study of provider engagement and knowledge gains
Meaney, P. A. Hokororo, A. Ndosi, H. Dahlen, et al.
BMJ Open. 2024; 14:e077834
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2024
Characteristics of children readmitted with severe pneumonia in Kenyan hospitals
Marangu-Boore, D. Mwaniki, P. Isaaka, L. Njoroge, et al.
BMC Public Health. 2024; 24:1324
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2024
Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya
Lugano, D. Kutima, B. Kimani, M. Sigilai, et al.
BMC Infect Dis. 2024; 24:1474
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2024
Prospective clinical surveillance for severe acute respiratory illness and COVID-19 vaccine effectiveness in Kenyan hospitals during the COVID-19 pandemic
Lucinde, R. K. Gathuri, H. Isaaka, L. Ogero, et al.
BMC Infect Dis. 2024; 24:1246
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2024
Comparative performance of the InBios SCoV-2 Detect (TM) IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations
Kutima, B. Kagucia, E. W. Mwai, K. Kimani, et al.
Wellcome Open Res. 2024; 9:349
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2023
Clinical epidemiology of COVID-19 among hospitalized children in rural western Kenya
Tsegaye, A. T. Sherry, C. Oduol, C. Otieno, et al.
PLOS Glob Public Health. 2023; 3:e0002011
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2023
Advocacy for Better Integration and Use of Child Health Indicators for Global Monitoring
Strong, K. Requejo, J. H. Billah, S. M. Schellenberg, et al.
Glob Health Sci Pract. 2023; 11
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2023
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study
Otiende, M. Nyaguara, A. Bottomley, C. Walumbe, et al.
Nat Commun. 2023; 14:6879
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2023
Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro
Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.
Int J Infect Dis. 2023; 127:11-16
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2023
Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review
Muller, S. A. Isaaka, L. Mumm, R. Scheidt-Nave, et al.
Lancet Glob Health. 2023; 11:e1713-e1724
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2023
SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-December 2022
Kagucia, E. W. Ziraba, A. K. Nyagwange, J. Kutima, et al.
Influenza Other Respir Viruses. 2023; 17:e13173
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2023
Symptom prevalence and secondary attack rate of SARS-CoV-2 in rural Kenyan households: A prospective cohort study
Gallagher, K. E. Nyiro, J. Agoti, C. N. Maitha, et al.
Influenza Other Respir Viruses. 2023; 17:e13185
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2023
Regular measurement is essential but insufficient to improve quality of healthcare
Agweyu, A. Hill, K. Diaz, T. Jackson, et al.
BMJ. 2023; 380:e073412
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2022
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
Tegally, H. San, J. E. Cotten, M. Moir, et al.
Science. 2022; 378:eabq5358
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2022
Epidemiological impact and cost-effectiveness analysis of COVID-19 vaccination in Kenya
Orangi, S. Ojal, J. Brand, S. P. Orlendo, et al.
BMJ Glob Health. 2022; 7
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2022
Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data
Ojal, J. Brand, S. P. C. Were, V. Okiro, et al.
Wellcome Open Res. 2022; 6:127
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2022
Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations
Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.
J Clin Virol. 2022; 146:105061
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2022
Unmet need for COVID-19 vaccination coverage in Kenya
Muchiri, S. K. Muthee, R. Kiarie, H. Sitienei, et al.
Vaccine. 2022; 40:2011-2019
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2022
Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21
Lucinde, R. K. Mugo, D. Bottomley, C. Karani, et al.
PLoS One. 2022; 17:e0265478
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2022
Malaria hospitalisation in East Africa: age, phenotype and transmission intensity
Kamau, A. Paton, R. S. Akech, S. Mpimbaza, et al.
BMC Med. 2022; 20:28
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2022
Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya
Etyang, A. O. Lucinde, R. Karanja, H. Kalu, et al.
Clin Infect Dis. 2022; 74:288-293
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2022
SARS-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021
Etyang, A. O. Adetifa, I. Omore, R. Misore, et al.
PLOS Glob Public Health. 2022; 2:e0000883
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2022
Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study
Agoti, C. N. Ochola-Oyier, L. I. Dellicour, S. Mohammed, et al.
Elife. 2022; 11
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2021
Prevalence of anti-SARS-CoV-2 IgG antibodies among Kenyan blood donors between June and August 2021.
Uyoga, S. Otiende, M. Adetifa, I. M. O. Karanja, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Prevalence of SARS-CoV-2 Antibodies From a National Serosurveillance of Kenyan Blood Donors, January-March 2021
Uyoga, S. Adetifa, I. M. O. Otiende, M. Yegon, et al.
JAMA. 2021; 326:1436-1438
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2021
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors
Uyoga, S. Adetifa, I. M. O. Karanja, H. K. Nyagwange, et al.
Science. 2021; 371:79-82
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2021
Pulse oximetry adoption and oxygen orders at paediatric admission over 7 years in Kenya: a multihospital retrospective cohort study
Tuti, T. Aluvaala, J. Akech, S. Agweyu, et al.
BMJ Open. 2021; 11:e050995
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2021
Revitalizing child health: lessons from the past
Strong, K. L. Requejo, J. Agweyu, A. Billah, et al.
Glob Health Action. 2021; 14:1947565
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2021
Malaria infection and severe disease risks in Africa
Paton, R. S. Kamau, A. Akech, S. Agweyu, et al.
Science. 2021; 373:926-931
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2021
All-cause and cause-specific mortality in Kilifi Health and Demographic Surveillance System, in Kenya in the period of the COVID-19 pandemic.
Otiende, M. Nyagura, A. Bottomley, C. Walumbe, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Mortality in rural coastal Kenya measured using the Kilifi Health and Demographic Surveillance System: a 16-year descriptive analysis
Otiende, M. Bauni, E. Nyaguara, A. Amadi, et al.
Wellcome Open Res. 2021; 6:327
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2021
Prevalence and fluid management of dehydration in children without diarrhoea admitted to Kenyan hospitals: a multisite observational study
Omoke, S. English, M. Aluvaala, J. Gathara, et al.
BMJ Open. 2021; 11:e042079
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2021
Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations.
Nyagwange, J. Kutima, B. Mwai, K. Karanja, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya
Kagucia, E. W. Gitonga, J. N. Kalu, C. Ochomo, et al.
Open Forum Infect Dis. 2021; 8:ofab314
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2021
High anti-SARS-CoV-2 IgG antibody seroprevalence among long-distance trucking crews in Kenya within one year of the COVID-19 pandemic.
Kagucia, E. W. Gitonga, J. N. Kalu, C. Kuya, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Neonatal mortality in Kenyan hospitals: a multisite, retrospective, cohort study
Irimu, G. Aluvaala, J. Malla, L. Omoke, et al.
BMJ Glob Health. 2021; 6
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2021
Genomic surveillance of SARS-CoV-2 in Kenya: March 2020-October 2021.
Githinji, G. Lambisia, W. A. Mohamed, K. S. Morobe, et al.
1st International Conference on Public Health in Africa (CPHIA-2021). 2021
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2021
Tracking the introduction and spread of SARS-CoV-2 in coastal Kenya
Githinji, G. de Laurent, Z. R. Mohammed, K. S. Omuoyo, et al.
Nat Commun. 2021; 12:4809
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2021
Serosurveillance for SARS-CoV-2 Antibodies in a cohort of Health Care Workers in Kenya.
Etyang, A. O. Lucinde, R. Gitonga, J. N. Kalu, et al.
1st International Conference on Public Health in Africa (CPHIA). 2021
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2021
Employing learning health system principles to advance research on severe neonatal and paediatric illness in Kenya
English, M. Irimu, G. Akech, S. Aluvaala, et al.
BMJ Glob Health. 2021; 6
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2021
COVID-19 transmission dynamics underlying epidemic waves in Kenya
Brand, S. P. C. Ojal, J. Aziza, R. Were, et al.
Science. 2021; 374:989-994
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2021
Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels
Bottomley, C. Otiende, M. Uyoga, S. Gallagher, et al.
Nat Commun. 2021; 12:6196
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2021
Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya
Adetifa, I. M. O. Uyoga, S. Gitonga, J. N. Mugo, et al.
Nat Commun. 2021; 12:3966
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2020
Child Health Accountability Tracking-extending child health measurement
Strong, K. Requejo, J. Agweyu, A. McKerrow, et al.
Lancet Child Adolesc Health. 2020; 4:259-261
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2020
Is the effect of COVID-19 on children underestimated in low- and middle- income countries?
Simba, J. Sinha, I. Mburugu, P. Agweyu, et al.
Acta Paediatr. 2020; 109:1930-1931
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2020
Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review
Ogero, M. Sarguta, R. J. Malla, L. Aluvaala, et al.
BMJ Open. 2020; 10:e035045
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2020
Methodological rigor of prognostic models for predicting in-hospital paediatric mortality in low- and middle-income countries: a systematic review protocol
Ogero, M. Sarguta, R. Malla, L. Aluvaala, et al.
Wellcome Open Res. 2020; 5:106
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2020
Examining which clinicians provide admission hospital care in a high mortality setting and their adherence to guidelines: an observational study in 13 hospitals
Ogero, M. Akech, S. Malla, L. Agweyu, et al.
Arch Dis Child. 2020; 105:648-654
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2020
Embracing the challenge of adolescent health in Kenya
Karianjahi, N. Mbogo, J. Wambugu, C. Tole, et al.
Lancet Child Adolesc Health. 2020; 4:101-103
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2020
The Clinical Profile of Severe Pediatric Malaria in an Area Targeted for Routine RTS,S/AS01 Malaria Vaccination in Western Kenya
Akech, S. Chepkirui, M. Ogero, M. Agweyu, et al.
Clin Infect Dis. 2020; 71:372-380
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2020
Protecting children in low-income and middle-income countries from COVID-19
Ahmed, S. Mvalo, T. Akech, S. Agweyu, et al.
BMJ Glob Health. 2020; 5
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2020
Extending the measurement of quality beyond service delivery indicators
Agweyu, A. Masenge, T. Munube, D.
BMJ Glob Health. 2020; 5
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2019
Risk factors for death among children aged 5-14 years hospitalised with pneumonia: a retrospective cohort study in Kenya
Macpherson, L. Ogero, M. Akech, S. Aluvaala, et al.
BMJ Glob Health. 2019; 4:e001715
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2019
The effects of aflatoxin exposure on Hepatitis B-vaccine induced immunity in Kenyan children
Githang'a, D. Wangia, R. N. Mureithi, M. W. Wandiga, et al.
Curr Probl Pediatr Adolesc Health Care. 2019; 49:117-130
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2019
The effects of exposures to mycotoxins on immunity in children: A systematic review
Githang'a, D. Anzala, O. Mutegi, C. Agweyu, et al.
Curr Probl Pediatr Adolesc Health Care. 2019; 49:109-116
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2019
Effect of enhancing audit and feedback on uptake of childhood pneumonia treatment policy in hospitals that are part of a clinical network: a cluster randomized trial
Ayieko, P. Irimu, G. Ogero, M. Mwaniki, et al.
Implement Sci. 2019; 14:20
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2018
Caregiver oral rehydration solution fluid monitoring charts versus standard care for the management of some dehydration among Kenyan children: a randomized controlled trial
Kailemia, M. Kariuki, N. Laving, A. Agweyu, et al.
Int Health. 2018; 10:442-450
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2018
Approaching quality improvement at scale: a learning health system approach in Kenya
Irimu, G. Ogero, M. Mbevi, G. Agweyu, et al.
Arch Dis Child. 2018; 103:1013-1019
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2018
Prevalence, outcome and quality of care among children hospitalized with severe acute malnutrition in Kenyan hospitals: A multi-site observational study
Gachau, S. Irimu, G. Ayieko, P. Akech, et al.
PLoS One. 2018; 13:e0197607
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2018
Risk factors for mortality and effect of correct fluid prescription in children with diarrhoea and dehydration without severe acute malnutrition admitted to Kenyan hospitals: an observational, association study
Akech, S. Ayieko, P. Gathara, D. Agweyu, et al.
Lancet Child Adolesc Health. 2018; 2:516-524
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2018
Comparable outcomes among trial and nontrial participants in a clinical trial of antibiotics for childhood pneumonia: a retrospective cohort study
Agweyu, A. Oliwa, J. Gathara, D. Muinga, et al.
J Clin Epidemiol. 2018; 94:1-7
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2018
Appropriateness of clinical severity classification of new WHO childhood pneumonia guidance: a multi-hospital, retrospective, cohort study
Agweyu, A. Lilford, R. J. English, M. Clinical Information Network Author, et al.
Lancet Glob Health. 2018; 6:e74-e83
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2017
An exploration of mortality risk factors in non-severe pneumonia in children using clinical data from Kenya
Tuti, T. Agweyu, A. Mwaniki, P. Peek, et al.
BMC Med. 2017; 15:201
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2017
Correction to: An exploration of mortality risk factors in non-severe pneumonia in children using clinical data from Kenya
Tuti, T. Agweyu, A. Mwaniki, P. Peek, et al.
BMC Med. 2017; 15:212
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2017
Does audit and feedback improve the adoption of recommended practices? Evidence from a longitudinal observational study of an emerging clinical network in Kenya
Gachau, S. Ayieko, P. Gathara, D. Mwaniki, et al.
BMJ Glob Health. 2017; 2:e000468
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2016
Building Learning Health Systems to Accelerate Research and Improve Outcomes of Clinical Care in Low- and Middle-Income Countries
English, M. Irimu, G. Agweyu, A. Gathara, et al.
PLoS Med. 2016; 13:e1001991
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2015
An unsupported preference for intravenous antibiotics
Li, H. K. Agweyu, A. English, M. Bejon, et al.
PLoS Med. 2015; 12:e1001825
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2015
Oral amoxicillin versus benzyl penicillin for severe pneumonia among kenyan children: a pragmatic randomized controlled noninferiority trial
Agweyu, A. Gathara, D. Oliwa, J. Muinga, et al.
Clin Infect Dis. 2015; 60:1216-24
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2015
Amoxicillin equivalent to parenteral antibiotics in the treatment of resource-deficient infants with tachypnea
Agweyu, A.
J Pediatr. 2015; 167:778-9
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2014
Trends in procurement costs for HIV commodities: a 7-year retrospective analysis of global fund data across 125 countries
Wafula, F. Agweyu, A. Macintyre, K.
J Acquir Immune Defic Syndr. 2014; 65:e134-9
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2014
Prevalence and correlates of treatment failure among Kenyan children hospitalised with severe community-acquired pneumonia: a prospective study of the clinical effectiveness of WHO pneumonia case management guidelines
Agweyu, A. Kibore, M. Digolo, L. Kosgei, et al.
Trop Med Int Health. 2014; 19:1310-20
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2013
Regional and temporal trends in malaria commodity costs: an analysis of Global Fund data for 79 countries
Wafula, F. Agweyu, A. Macintyre, K.
Malar J. 2013; 12:466
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2012
Experience developing national evidence-based clinical guidelines for childhood pneumonia in a low-income setting--making the GRADE?
Agweyu, A. Opiyo, N. English, M.
BMC Pediatr. 2012; 12:1