BACKGROUND: Malaria transmission has recently fallen in many parts of Africa, but systematic descriptions of infection and disease across all age groups are rare. Here, an epidemiological investigation of parasite prevalence, the incidence of fevers associated with infection, severe hospitalized disease and mortality among children older than 6 months and adults on the Kenyan coast is presented. METHODS: A prospective fever surveillance was undertaken at 6 out-patients (OPD) health-facilities between March 2018 and February 2019. Four community-based, cross sectional surveys of fever history and infection prevalence were completed among randomly selected homestead members from the same communities. Paediatric and adult malaria at Kilifi county hospital was obtained for the 12 months period. Rapid Diagnostic Tests (CareStart RDT) to detect HRP2-specific to Plasmodium falciparum was used in the community and the OPD, and microscopy in the hospital. Crude and age-specific incidence rates were computed using Poisson regression. RESULTS: Parasite prevalence gradually increased from childhood, reaching 12% by 9 years of age then declining through adolescence into adulthood. The incidence rate of RDT positivity in the OPD followed a similar trend to that of infection prevalence in the community. The incidence of hospitalized malaria from the same community was concentrated among children aged 6 months to 4 years (i.e. 64% and 70% of all hospitalized and severe malaria during the 12 months of surveillance, respectively). Only 3.7% (12/316) of deaths were directly attributable to malaria. Malaria mortality was highest among children aged 6 months-4 years at 0.57 per 1000 person-years (95% CI 0.2, 1.2). Severe malaria and death from malaria was negligible above 15 years of age. CONCLUSION: Under conditions of low transmission intensity, immunity to disease and the fatal consequences of infection appear to continue to be acquired in childhood and faster than anti-parasitic immunity. There was no evidence of an emerging significant burden of severe malaria or malaria mortality among adults. This is contrary to current modelled approaches to disease burden estimation in Africa and has important implications for the targeting of infection prevention strategies based on chemoprevention or vector control.
Kamau, A., Mtanje, G., Mataza, C., Mwambingu, G., Mturi, N., Mohammed, S., Ong’ayo, G., Nyutu, G., Nyaguara, A., Bejon, P., Snow, R. W.
Pages:210, Volume:19, Edition:6/20/2020, Date,Jun-17
Notes:Kamau, Alice|Mtanje, Grace|Mataza, Christine|Mwambingu, Gabriel|Mturi, Neema|Mohammed, Shebe|Ong’ayo, Gerald|Nyutu, Gideon|Nyaguara, Amek|Bejon, Philip|Snow, Robert W|eng|103602/WT_/Wellcome Trust/United Kingdom|212176/WT_/Wellcome Trust/United Kingdom|DEL-15-003/DELTAS Africa Initiative|England|2020/06/20 06:00|Malar J. 2020 Jun 17;19(1):210. doi: 10.1186/s12936-020-03286-6.
ISBN: 1475-2875 (Electronic)|1475-2875 (Linking) Permanent ID: PMC7301992 Accession Number: 32552891
Author Address: KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. firstname.lastname@example.org.|Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. email@example.com.|KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.|Ministry of Health, Kilifi County Government, Kilifi, Kenya.|Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.