A complete list of publications by Prof. Tom Williams. Use the filters to refine by year, journal or keyword.

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1. 2026
   Incidence of clinically diagnosed infections in children with sickle cell anaemia treated with oral hydroxyurea in Angola, DR Congo, Kenya, and Uganda: a retrospective cohort study from the REACH trial

   Williams, T. N. Smart, L. R. Tomlinson, G. Santos, et al.

   Lancet Haematol. 2026

   View abstract DOI PubMed
2. 2026
   Sevuparin in children with severe malaria: a phase I safety and dose-finding trial

   Chaponda, M. Gwasupika, J. Connon, R. Tshilab Kabwit, et al.

   Nat Commun. 2026; 17

   View abstract DOI PubMed
3. 2026
   Severe anaemia and invasive bacterial infections in Kenyan children: a 26-year hospital surveillance observational study

   Abuga, K. M. Muriuki, J. M. Mutua, A. M. Wambui, et al.

   Lancet Glob Health. 2026; 14:103976

   View abstract DOI PubMed
4. 2026
   Severe anaemia and invasive bacterial infections in Kenyan children: a 26-year hospital surveillance observational study

   Abuga, K. M. Muriuki, J. M. Mutua, A. M. Wambui, et al.

   Lancet Glob Health. 2026; 14:103976

   View abstract DOI PubMed
5. 2026
   Cumulative Plasmodium falciparum infections do not drive long-term telomere shortening in Kenyan children

   Miglar, A. Amadi, D. Grannas, D. Widman, et al.

   Front Cell Infect Microbiol. 2026; 16:1750881

   View abstract DOI PubMed
6. 2026
   Intravenous Artesunate in Artemisinin-Resistant Severe Malaria in Uganda

   Maitland, K. Okao, M. Conrad, M. D. Etwop, et al.

   N Engl J Med. 2026; 394:2380-2382

   View abstract DOI PubMed
7. 2026
   African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

   Muriuki, J. M. Mentzer, A. J. Band, G. Chong, et al.

   Nat Commun. 2026; 17

   View abstract DOI PubMed
8. 2026
   Growth and puberty in African children with sickle cell anemia treated with hydroxyurea

   Backeljauw, P. Tomlinson, G. Smart, L. R. Tshilolo, et al.

   Blood Adv. 2026; 10:4483-4494

   View abstract DOI PubMed
9. 2026
   Nasopharyngeal Microbiome Composition and its Clinical Correlates in Children Hospitalized with Severe Pneumonia in East Africa

   Makori, T. O. Gicheru, E. T. Mburu, M. W. Sada, et al.

   J Infect Dis. 2026

   View abstract DOI PubMed
10. 2026
    The Epidemiology of Sickle Cell Disease in Sub-Saharan Africa: Current Knowledge and Gaps to be Filled

    Ranque, B. Tshilolo, L. Williams, T. N.

    Am J Hematol. 2026; 101 Suppl 1:5-16

    View abstract DOI PubMed
11. 2026
    Hydroxyurea pharmacokinetics in children with sickle cell anemia across different global populations

    Power-Hays, A. McElhinney, K. E. Williams, T. N. Mochamah, et al.

    Blood Adv. 2026; 10:418-427

    View abstract DOI PubMed
12. 2026
    A cost-consequence analysis of the children's administration oxygenation strategies trial (COAST) in severe pneumonia

    Carroll, O. U. Grieve, R. Kiguli, S. Olupot-Olupot, et al.

    PLOS Glob Public Health. 2026; 6:e0005654

    View abstract DOI PubMed
13. 2025
    Malaria prophylaxis in sickle cell anaemia: some answers, more questions

    Williams, T. N. Ware, R. E.

    Lancet Infect Dis. 2025; 25:601-602

    View abstract DOI PubMed
14. 2025
    Single low dose primaquine to block the transmission of Plasmodium falciparum-proposed stand-alone and ACT-adapted regimens

    Taylor, W. R. J. Olupot-Olupot, P. Onyamboko, M. A. Chimjinda, et al.

    BMC Med. 2025; 23:397

    View abstract DOI PubMed
15. 2025
    Infections in sickle cell disease

    Scourfield, L. E. A. Nardo-Marino, A. Williams, T. N. Rees, et al.

    Haematologica. 2025; 110:546-561

    View abstract DOI PubMed
16. 2025
    OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

    Mogire, R. M. Muriuki, J. M. Bayimenye, R. F. Mentzer, et al.

    medRxiv. 2025

    View abstract DOI PubMed
17. 2025
    Early weaning from oxygen therapy in African children with severe pneumonia

    Maitland, K. Giallongo, E. Hamaluba, M. Alaroker, et al.

    BMC Med. 2025; 23:366

    View abstract DOI PubMed
18. 2025
    Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study

    Kariuki, S. N. Gilchrist, J. J. Uyoga, S. Macharia, et al.

    J Infect Dis. 2025; 231:e10-e16

    View abstract DOI PubMed
19. 2025
    Comparing HemoCue(R) and Quantitative Buffy Coat(R) and Coulter Counter-measured haemoglobin concentrations in African children with acute uncomplicated malaria: a Bland-Altman analysis

    Ayuen, D. S. Olupot-Olupot, P. Muhindo, R. Onyamboko, et al.

    Malar J. 2025; 24:77

    View abstract DOI PubMed
20. 2025
    Plasma folate dynamics in Plasmodium falciparum-infected African children treated with artemisinin combination therapy and single low-dose primaquine or placebo

    Ajayi, S. Onyamboko, M. A. Olupot-Olupot, P. Ayuen, et al.

    Malar J. 2025; 24:342

    View abstract DOI PubMed
21. 2024
    Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial

    Power-Hays, A. Tomlinson, G. A. Tshilolo, L. Santos, et al.

    Am J Hematol. 2024; 99:625-632

    View abstract DOI PubMed
22. 2024
    A Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial)

    Maitland, K. Obonyo, N. Hamaluba, M. Ogoda, et al.

    Wellcome Open Res. 2024; 9:281

    View abstract DOI PubMed
23. 2023
    SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART)

    Maitland, K. Hamaluba, M. Obonyo, N. Oguda, et al.

    Wellcome Open Res. 2023; 8:484

    View abstract DOI PubMed
24. 2024
    Nutritional supplementation in children with severe pneumonia in Uganda and Kenya (COAST-Nutrition): a phase 2 randomised controlled trial

    Kiguli, S. Olupot-Olupot, P. Hamaluba, M. Giallongo, et al.

    EClinicalMedicine. 2024; 72:102640

    View abstract DOI PubMed
25. 2024
    Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial

    Connon, R. Olupot-Olupot, P. Pistorius, A. M. A. Okiror, et al.

    BMC Med. 2024; 22:516

    View abstract DOI PubMed
26. 2024
    Dantu Blood Group Erythrocytes Form Large Plasmodium falciparum Rosettes Less Commonly

    Carlier, M. S. A. Nyamu, W. Makale, J. Williams, et al.

    Am J Trop Med Hyg. 2024; 110:436-443

    View abstract DOI PubMed
27. 2024
    Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial

    Aygun, B. Lane, A. Smart, L. R. Santos, et al.

    Lancet Haematol. 2024; 11:e425-e435

    View abstract DOI PubMed
28. 2023
    Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial

    Taylor, W. R. Olupot-Olupot, P. Onyamboko, M. A. Peerawaranun, et al.

    Lancet Infect Dis. 2023; 23:471-483

    View abstract DOI PubMed
29. 2023
    Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study

    Otiende, M. Nyaguara, A. Bottomley, C. Walumbe, et al.

    Nat Commun. 2023; 14:6879

    View abstract DOI PubMed
30. 2023
    Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria

    Opi, D. H. Ndila, C. M. Uyoga, S. Macharia, et al.

    PLoS Genet. 2023; 19:e1010910

    View abstract DOI PubMed
31. 2023
    Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo

    Onyamboko, M. A. Olupot-Olupot, P. Were, W. Namayanja, et al.

    BMC Med. 2023; 21:397

    View abstract DOI PubMed
32. 2023
    Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa

    Olupot-Olupot, P. Tomlinson, G. Williams, T. N. Tshilolo, et al.

    Blood. 2023; 141:1402-1410

    View abstract DOI PubMed
33. 2021
    Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial

    Olupot-Olupot, P. Okiror, W. Mnjalla, H. Muhindo, et al.

    Wellcome Open Res. 2021; 6:161

    View abstract DOI PubMed
34. 2023
    Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria

    Odera, D. O. Tuju, J. Mwai, K. Nkumama, et al.

    Sci Transl Med. 2023; 15:eabn5993

    View abstract DOI PubMed
35. 2023
    Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria

    Mukaka, M. Onyamboko, M. A. Olupot-Olupot, P. Peerawaranun, et al.

    EBioMedicine. 2023; 96:104805

    View abstract DOI PubMed
36. 2023
    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Kariuki, S. N. Macharia, A. W. Makale, J. Nyamu, et al.

    Elife. 2023; 12

    View abstract DOI PubMed
37. 2022
    Risk factors of anaemia and iron deficiency in Somali children and women: Findings from the 2019 Somalia Micronutrient Survey

    Wirth, J. P. Sesay, F. Mbai, J. Ali, et al.

    Matern Child Nutr. 2022; 18:e13254

    View abstract DOI PubMed
38. 2022
    Filling the data gaps on sickle cell anaemia in sub-Saharan Africa

    Williams, T. N.

    Lancet Haematol. 2022; 9:e172-e173

    View abstract DOI PubMed
39. 2022
    Substantial misdiagnosis of severe malaria in African children

    White, N. J. Watson, J. A. Uyoga, S. Williams, et al.

    Lancet. 2022; 400:807

    View abstract DOI PubMed
40. 2022
    Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations

    Watson, J. A. Uyoga, S. Wanjiku, P. Makale, et al.

    Sci Transl Med. 2022; 14:eabn5040

    View abstract DOI PubMed
41. 2022
    The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria

    Uyoga, S. Watson, J. A. Wanjiku, P. Rop, et al.

    Nat Commun. 2022; 13:3307

    View abstract DOI PubMed
42. 2022
    Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT)

    Uyoga, S. Olupot-Olupot, P. Connon, R. Kiguli, et al.

    Lancet Child Adolesc Health. 2022; 6:606-613

    View abstract DOI PubMed
43. 2022
    A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa

    Olupot-Olupot, P. Connon, R. Kiguli, S. Opoka, et al.

    Am J Hematol. 2022; 97:527-536

    View abstract DOI PubMed
44. 2022
    The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia

    Njunge, J. M. Tickell, K. Diallo, A. H. Sayeem Bin Shahid, et al.

    Gates Open Res. 2022; 6:77

    View abstract DOI PubMed
45. 2022
    The significance of spleen size in children with sickle cell anemia

    Nardo-Marino, A. Glenthoj, A. Brewin, J. N. Petersen, et al.

    Am J Hematol. 2022; 97:1520-1528

    View abstract DOI PubMed
46. 2022
    Automating Pitted Red Blood Cell Counts Using Deep Neural Network Analysis: A New Method for Measuring Splenic Function in Sickle Cell Anaemia

    Nardo-Marino, A. Braunstein, T. H. Petersen, J. Brewin, et al.

    Front Physiol. 2022; 13:859906

    View abstract DOI PubMed
47. 2022
    Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria

    Musasia, F. K. Nkumama, I. N. Frank, R. Kipkemboi, et al.

    Nature Communications. 2022; 13:4098

    View abstract DOI PubMed
48. 2022
    Vitamin D Deficiency and Its Association with Iron Deficiency in African Children

    Mogire, R. M. Muriuki, J. M. Morovat, A. Mentzer, et al.

    Nutrients. 2022; 14

    View abstract DOI PubMed
49. 2022
    BIRC6 modifies risk of invasive bacterial infection in Kenyan children

    Gilchrist, J. J. Kariuki, S. N. Watson, J. A. Band, et al.

    Elife. 2022; 11

    View abstract DOI PubMed
50. 2022
    Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial

    George, E. C. Uyoga, S. M'Baya, B. Kyeyune Byabazair, et al.

    Lancet Glob Health. 2022; 10:e360-e368

    View abstract DOI PubMed
51. 2022
    Malaria protection due to sickle haemoglobin depends on parasite genotype

    Band, G. Leffler, E. M. Jallow, M. Sisay-Joof, et al.

    Nature. 2022; 602:106-111

    View abstract DOI PubMed
52. 2022
    Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia

    Abuga, K. M. Muriuki, J. M. Uyoga, S. M. Mwai, et al.

    Haematologica. 2022; 107:1589-1598

    View abstract DOI PubMed
53. 2021
    Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa

    Williams, T. N.

    BMC Med. 2021; 19:17

    View abstract DOI PubMed
54. 2021
    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    Watson, J. A. Ndila, C. M. Uyoga, S. Macharia, et al.

    Elife. 2021; 10

    View abstract DOI PubMed
55. 2021
    Plasma Plasmodium falciparum Histidine-rich Protein 2 Concentrations in Children With Malaria Infections of Differing Severity in Kilifi, Kenya

    Uyoga, S. Wanjiku, P. Rop, J. C. Makale, et al.

    Clin Infect Dis. 2021; 73:e2415-e2423

    View abstract DOI PubMed
56. 2021
    Risk factors for anaemia among Ghanaian women and children vary by population group and climate zone

    Petry, N. Wirth, J. P. Adu-Afarwuah, S. Wegmuller, et al.

    Matern Child Nutr. 2021; 17:e13076

    View abstract DOI PubMed
57. 2021
    Mortality in rural coastal Kenya measured using the Kilifi Health and Demographic Surveillance System: a 16-year descriptive analysis

    Otiende, M. Bauni, E. Nyaguara, A. Amadi, et al.

    Wellcome Open Res. 2021; 6:327

    View abstract DOI PubMed
58. 2021
    Malaria is a cause of iron deficiency in African children

    Muriuki, J. M. Mentzer, A. J. Mitchell, R. Webb, et al.

    Nat Med. 2021; 27:653-658

    View abstract DOI PubMed
59. 2021
    Prevalence and predictors of vitamin D deficiency in young African children

    Mogire, R. M. Morovat, A. Muriuki, J. M. Mentzer, et al.

    BMC Med. 2021; 19:115

    View abstract DOI PubMed
60. 2021
    Transfusion management of severe anaemia in African children: a consensus algorithm

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Opoka, et al.

    Br J Haematol. 2021; 193:1247-1259

    View abstract DOI PubMed
61. 2021
    Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Hamaluba, et al.

    Intensive Care Med. 2021; 47:566-576

    View abstract DOI PubMed
62. 2021
    Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial

    Kiguli, S. Olopot-Olupot, P. Alaroker, F. Engoru, et al.

    Wellcome Open Res. 2021; 6:221

    View abstract DOI PubMed
63. 2021
    Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data

    Connon, R. George, E. C. Olupot-Olupot, P. Kiguli, et al.

    BMC Public Health. 2021; 21:1480

    View abstract DOI PubMed
64. 2021
    Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children

    Bundi, C. K. Nalwoga, A. Lubyayi, L. Muriuki, et al.

    Clin Infect Dis. 2021; 73:43-49

    View abstract DOI PubMed
65. 2020
    Anemia, micronutrient deficiencies, malaria, hemoglobinopathies and malnutrition in young children and non-pregnant women in Ghana: Findings from a national survey

    Wegmuller, R. Bentil, H. Wirth, J. P. Petry, et al.

    PLoS One. 2020; 15:e0228258

    View abstract DOI PubMed
66. 2020
    Glucose-6-phosphate dehydrogenase deficiency and susceptibility to childhood diseases in Kilifi, Kenya

    Uyoga, S. Macharia, A. W. Ndila, C. M. Nyutu, et al.

    Blood Adv. 2020; 4:5942-5950

    View abstract DOI PubMed
67. 2020
    Clustering of health risk behaviors among adolescents in Kilifi, Kenya, a rural Sub-Saharan African setting

    Ssewanyana, D. Abubakar, A. Newton, C. R. J. C. Otiende, et al.

    PLoS One. 2020; 15:e0242186

    View abstract DOI PubMed
68. 2020
    Caring for Africa's sickle cell children: will we rise to the challenge?

    Oron, A. P. Chao, D. L. Ezeanolue, E. E. Ezenwa, et al.

    BMC Med. 2020; 18:92

    View abstract DOI PubMed
69. 2020
    Characterising demographics, knowledge, practices and clinical care among patients attending sickle cell disease clinics in Eastern Uganda

    Olupot-Olupot, P. Wabwire, H. Ndila, C. Adong, et al.

    Wellcome Open Res. 2020; 5:87

    View abstract DOI PubMed
70. 2020
    The clinical spectrum of severe childhood malaria in Eastern Uganda

    Olupot-Olupot, P. Engoru, C. Nteziyaremye, J. Chebet, et al.

    Malar J. 2020; 19:322

    View abstract DOI PubMed
71. 2020
    Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑alpha (3.7I) form of alpha-thalassaemia using genome-wide microarray data

    Ndila, C. M. Nyirongo, V. Macharia, A. W. Jeffreys, et al.

    Wellcome Open Res. 2020; 5:287

    View abstract DOI PubMed
72. 2020
    Vitamin D Status Is Not Associated with Cognitive or Motor Function in Pre-School Ugandan Children

    Mutua, A. M. Nampijja, M. Elliott, A. M. Pettifor, et al.

    Nutrients. 2020; 12

    View abstract DOI PubMed
73. 2020
    Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review

    Mutua, A. M. Mogire, R. M. Elliott, A. M. Williams, et al.

    Wellcome Open Res. 2020; 5:28

    View abstract DOI PubMed
74. 2020
    Estimating the burden of iron deficiency among African children

    Muriuki, J. M. Mentzer, A. J. Webb, E. L. Morovat, et al.

    BMC Med. 2020; 18:31

    View abstract DOI PubMed
75. 2020
    Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis

    Mogire, R. M. Mutua, A. Kimita, W. Kamau, et al.

    Lancet Glob Health. 2020; 8:e134-e142

    View abstract DOI PubMed
76. 2020
    Author Correction: Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya

    Malinga, J. Mogeni, P. Omedo, I. Rockett, et al.

    Sci Rep. 2020; 10:22416

    View abstract DOI PubMed
77. 2020
    beta-Thalassemia pathogenic variants in a cohort of children from the East African coast

    Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, et al.

    Mol Genet Genomic Med. 2020; 8:e1294

    View abstract DOI PubMed
78. 2020
    Human genetics and malaria resistance

    Kariuki, S. N. Williams, T. N.

    Hum Genet. 2020; 139:801-811

    View abstract DOI PubMed
79. 2020
    Red blood cell tension protects against severe malaria in the Dantu blood group

    Kariuki, S. N. Marin-Menendez, A. Introini, V. Ravenhill, et al.

    Nature. 2020; 585:579-583

    View abstract DOI PubMed
80. 2020
    Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency

    Gilchrist, J. J. Uyoga, S. Pirinen, M. Rautanen, et al.

    BMC Med. 2020; 18:148

    View abstract DOI PubMed
81. 2020
    How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children

    Abuga, K. M. Muriuki, J. M. Williams, T. N. Atkinson, et al.

    Int J Mol Sci. 2020; 21

    View abstract DOI PubMed
82. 2019
    Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa

    Uyoga, S. Mpoya, A. Olupot-Olupot, P. Kiguli, et al.

    Vox Sang. 2019; 114:340-348

    View abstract DOI PubMed
83. 2019
    The indirect health effects of malaria estimated from health advantages of the sickle cell trait

    Uyoga, S. Macharia, A. W. Ndila, C. M. Nyutu, et al.

    Nat Commun. 2019; 10:856

    View abstract DOI PubMed
84. 2019
    The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study

    Uyoga, S. Macharia, A. W. Mochamah, G. Ndila, et al.

    Lancet Glob Health. 2019; 7:e1458-e1466

    View abstract DOI PubMed
85. 2019
    Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

    Tshilolo, L. Tomlinson, G. Williams, T. N. Santos, et al.

    N Engl J Med. 2019; 380:121-131

    View abstract DOI PubMed
86. 2019
    Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis

    Silaba, M. Ooko, M. Bottomley, C. Sande, et al.

    Lancet Glob Health. 2019; 7:e337-e346

    View abstract DOI PubMed
87. 2019
    Effect of strikes by health workers on mortality between 2010 and 2016 in Kilifi, Kenya: a population-based cohort analysis

    Ong'ayo, G. Ooko, M. Wang'ondu, R. Bottomley, et al.

    Lancet Glob Health. 2019; 7:e961-e967

    View abstract DOI PubMed
88. 2019
    Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya

    Njuguna, P. Maitland, K. Nyaguara, A. Mwanga, et al.

    BMC Med. 2019; 17:124

    View abstract DOI PubMed
89. 2019
    Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort

    Muthui, M. K. Mogeni, P. Mwai, K. Nyundo, et al.

    Wellcome Open Res. 2019; 4:66

    View abstract DOI PubMed
90. 2019
    Iron Status and Associated Malaria Risk Among African Children

    Muriuki, J. M. Mentzer, A. J. Kimita, W. Ndungu, et al.

    Clin Infect Dis. 2019; 68:1807-1814

    View abstract DOI PubMed
91. 2019
    The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

    Muriuki, J. M. Mentzer, A. J. Band, G. Gilchrist, et al.

    Sci Adv. 2019; 5:eaaw0109

    View abstract DOI PubMed
92. 2019
    Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya

    Malinga, J. Mogeni, P. Omedo, I. Rockett, et al.

    Sci Rep. 2019; 9:19018

    View abstract DOI PubMed
93. 2019
    Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial

    Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.

    Lancet Glob Health. 2019; 7:e1435-e1447

    View abstract DOI PubMed
94. 2019
    Transfusion Volume for Children with Severe Anemia in Africa

    Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.

    N Engl J Med. 2019; 381:420-431

    View abstract DOI PubMed
95. 2019
    Informing thresholds for paediatric transfusion in Africa: the need for a trial

    Maitland, K. Ohuma, E. O. Mpoya, A. Uyoga, et al.

    Wellcome Open Res. 2019; 4:27

    View abstract DOI PubMed
96. 2019
    Immediate Transfusion in African Children with Uncomplicated Severe Anemia

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Engoru, et al.

    N Engl J Med. 2019; 381:407-419

    View abstract DOI PubMed
97. 2019
    The population dynamics of hemoglobins A, A(2), F and S in the context of the hemoglobinopathies HbS and alpha-thalassemia in Kenyan infants

    Macharia, A. W. Uyoga, S. Ndila, C. Nyutu, et al.

    Haematologica. 2019; 104:e184-e186

    View abstract DOI PubMed
98. 2019
    Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study

    Hammitt, L. L. Etyang, A. O. Morpeth, S. C. Ojal, et al.

    Lancet. 2019; 393:2146-2154

    View abstract DOI PubMed
99. 2019
    Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study

    Etyang, A. O. Kapesa, S. Odipo, E. Bauni, et al.

    J Am Heart Assoc. 2019; 8:e011771

    View abstract DOI PubMed
100. 2019
     IgM in human immunity to Plasmodium falciparum malaria

     Boyle, M. J. Chan, J. A. Handayuni, I. Reiling, et al.

     Sci Adv. 2019; 5:eaax4489

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101. 2018
     Sickle Cell Anemia and Its Phenotypes

     Williams, T. N. Thein, S. L.

     Annu Rev Genomics Hum Genet. 2018; 19:113-147

     View abstract DOI PubMed
102. 2018
     Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

     Taylor, W. R. Naw, H. K. Maitland, K. Williams, et al.

     BMC Med. 2018; 16:11

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103. 2018
     Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia

     Opi, D. H. Swann, O. Macharia, A. Uyoga, et al.

     Elife. 2018; 7

     View abstract DOI PubMed
104. 2018
     Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda

     Olupot-Olupot, P. Prevatt, N. Engoru, C. Nteziyaremye, et al.

     Wellcome Open Res. 2018; 3:130

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105. 2018
     Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

     Ndila, C. M. Uyoga, S. Macharia, A. W. Nyutu, et al.

     Lancet Haematol. 2018; 5:e333-e345

     View abstract DOI PubMed
106. 2018
     Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa

     McGann, P. T. Williams, T. N. Olupot-Olupot, P. Tomlinson, et al.

     Am J Hematol. 2018; 93:537-545

     View abstract DOI PubMed
107. 2018
     The clinical epidemiology of sickle cell anemia In Africa

     Macharia, A. W. Mochamah, G. Uyoga, S. Ndila, et al.

     Am J Hematol. 2018; 93:363-370

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108. 2018
     Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

     Gilchrist, J. J. Rautanen, A. Fairfax, B. P. Mills, et al.

     Nat Commun. 2018; 9:1014

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109. 2018
     Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children

     Gilchrist, J. J. Mentzer, A. J. Rautanen, A. Pirinen, et al.

     Proc Natl Acad Sci U S A. 2018; 115:E3601-E3603

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110. 2018
     Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait

     Etyang, A. O. Wandabwa, C. K. Kapesa, S. Muthumbi, et al.

     Am J Epidemiol. 2018; 187:199-205

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111. 2018
     Sickle Cell and alpha+-Thalassemia Traits Influence the Association between Ferritin and Hepcidin in Rural Kenyan Children Aged 14-26 Months

     Byrd, K. A. Williams, T. N. Lin, A. Pickering, et al.

     J Nutr. 2018; 148:1903-1910

     View abstract DOI PubMed
112. 2018
     Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya

     Brent, A. J. Nyundo, C. Langat, J. Mulunda, et al.

     Emerg Infect Dis. 2018; 24:514-523

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113. 2018
     Coverage and timeliness of vaccination and the validity of routine estimates: Insights from a vaccine registry in Kenya

     Adetifa, I. M. O. Karia, B. Mutuku, A. Bwanaali, et al.

     Vaccine. 2018; 36:7965-7974

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114. 2017
     Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

     Wang, L. Ko, E. R. Gilchrist, J. J. Pittman, et al.

     Sci Adv. 2017; 3:e1602096

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115. 2017
     No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes

     Swann, O. V. Harrison, E. M. Opi, D. H. Nyatichi, et al.

     Sci Rep. 2017; 7:17825

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116. 2017
     Subphenotypes of sickle cell disease in Africa

     Piel, F. B. Williams, T. N.

     Blood. 2017; 130:2157-2158

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117. 2017
     High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda

     Olupot-Olupot, P. Engoru, C. Uyoga, S. Muhindo, et al.

     Clin Infect Dis. 2017; 64:939-946

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118. 2017
     Linking health facility data from young adults aged 18-24 years to longitudinal demographic data: Experience from The Kilifi Health and Demographic Surveillance System [version 1; referees: 1 approved, 1 approved with reservations]

     Nyundo, C Doyle, AM Walumbe, D Otiende, et al.

     Wellcome Open Res. 2017; 2

     View abstract PubMed
119. 2017
     The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study

     Nardo-Marino, A. Williams, T. N. Olupot-Olupot, P.

     BMC Hematol. 2017; 17:14

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120. 2017
     Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children

     Mugyenyi, C. K. Elliott, S. R. Yap, X. Z. Feng, et al.

     J Infect Dis. 2017; 216:887-898

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121. 2017
     Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction

     Mogeni, P. Williams, T. N. Omedo, I. Kimani, et al.

     J Infect Dis. 2017; 216:1091-1098

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122. 2017
     Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

     McCallum, F. J. Persson, K. E. Fowkes, F. J. Reiling, et al.

     J Leukoc Biol. 2017; 101:913-925

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123. 2017
     Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

     Maitland, K. Kiguli, S. Opoka, R. O. Olupot-Olupot, et al.

     Wellcome Open Res. 2017; 2:100

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124. 2017
     Resistance to malaria through structural variation of red blood cell invasion receptors

     Leffler, E. M. Band, G. Busby, G. B. J. Kivinen, et al.

     Science. 2017; 356

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125. 2017
     Blood Pressure and Arterial Stiffness in Kenyan Adolescents With alpha(+)Thalassemia

     Etyang, A. O. Khayeka-Wandabwa, C. Kapesa, S. Muthumbi, et al.

     J Am Heart Assoc. 2017; 6

     View abstract DOI PubMed
126. 2017
     Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaounde and Douala, Cameroon

     Engle-Stone, R. Williams, T. N. Nankap, M. Ndjebayi, et al.

     Nutrients. 2017; 9

     View abstract DOI PubMed
127. 2017
     Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

     Clarke, G. M. Rockett, K. Kivinen, K. Hubbart, et al.

     Elife. 2017; 6

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128. 2017
     Cohort Profile: The Kilifi Vaccine Monitoring Study

     Adetifa, I. M. O. Bwanaali, T. Wafula, J. Mutuku, et al.

     Int J Epidemiol. 2017; 46:792-792h

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129. 2016
     Sickle Cell Disease in Sub-Saharan Africa

     Williams, T. N.

     Hematol Oncol Clin North Am. 2016; 30:343-58

     View abstract DOI PubMed
130. 2016
     Host Genetics

     Williams, T.N.

     Advances in Malaria research. 2016

     View abstract
131. 2016
     Invasive Group A Streptococcus Infection among Children, Rural Kenya

     Seale, A. C. Davies, M. R. Anampiu, K. Morpeth, et al.

     Emerg Infect Dis. 2016; 22:224-32

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132. 2016
     Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: deviations from Hardy-Weinberg equilibrium

     Piel, F. B. Adamkiewicz, T. V. Amendah, D. Williams, et al.

     Genet Med. 2016; 18:265-74

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133. 2016
     Red blood cell complement receptor one level varies with Knops blood group, alpha(+)thalassaemia and age among Kenyan children

     Opi, D. H. Uyoga, S. Orori, E. N. Williams, et al.

     Genes Immun. 2016; 17:171-8

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134. 2016
     Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study

     Mogeni, P. Williams, T. N. Fegan, G. Nyundo, et al.

     PLoS Med. 2016; 13:e1002047

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135. 2016
     Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub-Saharan Africa: Rationale and Design of the REACH Trial

     McGann, P. T. Tshilolo, L. Santos, B. Tomlinson, et al.

     Pediatr Blood Cancer. 2016; 63:98-104

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136. 2016
     Environmental Correlation Analysis for Genes Associated with Protection against Malaria

     Mackinnon, M. J. Ndila, C. Uyoga, S. Macharia, et al.

     Mol Biol Evol. 2016; 33:1188-204

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137. 2016
     Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

     Kenyan Bacteraemia Study, Group Wellcome Trust Case Control, Consortium Rautanen, A. Pirinen, et al.

     Am J Hum Genet. 2016; 98:1092-1100

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138. 2015
     Infections and the common inherited haemoglobin disorders

     Williams, T.N. Weatherall, D.J.

     Cohen, Powderly & Opal Infectious Diseases. 2015

     View abstract
139. 2015
     Red blood cell variants and malaria: a long story not yet over

     Williams, T. N.

     Lancet Haematol. 2015; 2:e130-1

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140. 2015
     Sickle Cell Disease in sub-Saharan Africa

     Williams, T.N.

     Global Hematology/Oncology Clinics of North America. 2015

     View abstract
141. 2015
     An accurate and affordable test for the rapid diagnosis of sickle cell disease could revolutionize the outlook for affected children born in resource-limited settings

     Williams, T. N.

     BMC Med. 2015; 13:238

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142. 2015
     Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study

     Uyoga, S. Ndila, C. M. Macharia, A. W. Nyutu, et al.

     Lancet Haematol. 2015; 2:e437-44

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143. 2015
     Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

     Shelton, J. M. Corran, P. Risley, P. Silva, et al.

     Malar J. 2015; 14:333

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144. 2015
     Sickle Cell Anemia: history and epidemiology

     Piel, F.B. Williams, T.N.

     Sickle Cell Anemia: from basic science to clinical practice. 2015

     View abstract
145. 2015
     Erratum to "Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and alpha(+)thalassemia" [EBioMedicine 1 (2014) 29-36]

     Opi, D. H. Ochola, L. B. Tendwa, M. Siddondo, et al.

     EBioMedicine. 2015; 2:1001

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146. 2015
     Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models

     Ndungu, F. M. Marsh, K. Fegan, G. Wambua, et al.

     BMC Med. 2015; 13:183

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147. 2015
     Invasive Salmonellosis in Kilifi, Kenya

     Muthumbi, E. Morpeth, S. C. Ooko, M. Mwanzu, et al.

     Clin Infect Dis. 2015; 61 Suppl 4:S290-301

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148. 2015
     Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

     Mpoya, A. Kiguli, S. Olupot-Olupot, P. Opoka, et al.

     Trials. 2015; 16:593

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149. 2015
     Genetic variants associated with non-typhoidal Salmonella bacteraemia in African children

     Gilchrist, J. J. Mills, T. C. Naranbhai, V. Chapman, et al.

     Lancet. 2015; 385 Suppl 1:S13

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150. 2015
     Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition

     G. B. D. DALYs Hale Collaborators Murray, C. J. Barber, R. M. Foreman, K. J. Abbasoglu Ozgoren, et al.

     Lancet. 2015; 386:2145-91

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151. 2015
     Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

     G. B. D. Risk Factors Collaborators Forouzanfar, M. H. Alexander, L. Anderson, H. R. Bachman, et al.

     Lancet. 2015; 386:2287-323

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152. 2015
     Sickle cell disease: a neglected chronic disease of increasing global health importance

     Chakravorty, S. Williams, T. N.

     Arch Dis Child. 2015; 100:48-53

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153. 2015
     Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya

     Atkinson, S. H. Uyoga, S. M. Armitage, A. E. Khandwala, et al.

     EBioMedicine. 2015; 2:1478-86

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154. 2014
     An assessment of the impact of host polymorphisms on Plasmodium falciparum var gene expression patterns among Kenyan children

     Warimwe, G. M. Fegan, G. Kiragu, E. W. Musyoki, et al.

     BMC Infect Dis. 2014; 14:524

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155. 2014
     Nutritional status of young children with inherited blood disorders in western Kenya

     Tsang, B. L. Sullivan, K. M. Ruth, L. J. Williams, et al.

     Am J Trop Med Hyg. 2014; 90:955-962

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156. 2014
     The burden and consequences of inherited blood disorders among young children in western Kenya

     Suchdev, P. S. Ruth, L. J. Earley, M. Macharia, et al.

     Matern Child Nutr. 2014; 10:135-44

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157. 2014
     Cause-specific childhood mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

     Streatfield, P. K. Khan, W. A. Bhuiya, A. Hanifi, et al.

     Glob Health Action. 2014; 7:25363

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158. 2014
     HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

     Streatfield, P. K. Khan, W. A. Bhuiya, A. Hanifi, et al.

     Glob Health Action. 2014; 7:25370

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159. 2014
     Malaria mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

     Streatfield, P. K. Khan, W. A. Bhuiya, A. Hanifi, et al.

     Glob Health Action. 2014; 7:25369

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160. 2014
     Mortality from external causes in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System Sites

     Streatfield, P. K. Khan, W. A. Bhuiya, A. Hanifi, et al.

     Glob Health Action. 2014; 7:25366

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161. 2014
     Adult non-communicable disease mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites

     Streatfield, P. K. Khan, W. A. Bhuiya, A. Hanifi, et al.

     Glob Health Action. 2014; 7:25365

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162. 2014
     Cause-specific mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

     Streatfield, P. K. Khan, W. A. Bhuiya, A. Alam, et al.

     Glob Health Action. 2014; 7:25362

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163. 2014
     Pregnancy-related mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites

     Streatfield, P. K. Alam, N. Compaore, Y. Rossier, et al.

     Glob Health Action. 2014; 7:25368

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164. 2014
     Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya

     Shah, S. S. Macharia, A. Makale, J. Uyoga, et al.

     BMC Med Genet. 2014; 15:93

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165. 2014
     Global migration and the changing distribution of sickle haemoglobin: a quantitative study of temporal trends between 1960 and 2000

     Piel, F. B. Tatem, A. J. Huang, Z. Gupta, et al.

     Lancet Glob Health. 2014; 2:e80-9

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166. 2014
     Managing the burden of sickle-cell disease in Africa

     Piel, F. B. Rees, D. C. Williams, T. N.

     Lancet Haematol. 2014; 1:e11-2

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167. 2014
     Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and alpha(+)thalassemia

     Opi, D. H. Ochola, L. B. Tendwa, M. Siddondo, et al.

     EBioMedicine. 2014; 1:29-36

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168. 2014
     Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

     Olupot-Olupot, P. Engoru, C. Thompson, J. Nteziyaremye, et al.

     BMC Med. 2014; 12:67

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169. 2014
     Verbal autopsy as a tool for identifying children dying of sickle cell disease: a validation study conducted in Kilifi district, Kenya

     Ndila, C. Bauni, E. Nyirongo, V. Mochamah, et al.

     BMC Med. 2014; 12:65

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170. 2014
     Causes of death among persons of all ages within the Kilifi Health and Demographic Surveillance System, Kenya, determined from verbal autopsies interpreted using the InterVA-4 model

     Ndila, C. Bauni, E. Mochamah, G. Nyirongo, et al.

     Glob Health Action. 2014; 7:25593

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171. 2014
     Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

     Murray, C. J. Ortblad, K. F. Guinovart, C. Lim, et al.

     Lancet. 2014; 384:1005-70

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172. 2014
     Remembering the forgotten non-communicable diseases

     Lopez, A. D. Williams, T. N. Levin, A. Tonelli, et al.

     BMC Med. 2014; 12:200

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173. 2014
     Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

     Hodgson, S. H. Juma, E. Salim, A. Magiri, et al.

     Front Microbiol. 2014; 5:686

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174. 2014
     Burden of disease in adults admitted to hospital in a rural region of coastal Kenya: an analysis of data from linked clinical and demographic surveillance systems

     Etyang, A. O. Munge, K. Bunyasi, E. W. Matata, et al.

     Lancet Glob Health. 2014; 2:e216-24

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175. 2014
     Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa

     de Vries, J. Williams, T. N. Bojang, K. Kwiatkowski, et al.

     BMC Med Ethics. 2014; 15:62

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176. 2014
     A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots

     Bejon, P. Williams, T. N. Nyundo, C. Hay, et al.

     Elife. 2014; 3:e02130

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177. 2014
     Epistasis between the haptoglobin common variant and alpha+thalassemia influences risk of severe malaria in Kenyan children

     Atkinson, S. H. Uyoga, S. M. Nyatichi, E. Macharia, et al.

     Blood. 2014; 123:2008-16

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178. 2014
     Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children

     Atkinson, S. H. Armitage, A. E. Khandwala, S. Mwangi, et al.

     Blood. 2014; 123:3221-9

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179. 2013
     Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

     Piel, F. B. Patil, A. P. Howes, R. E. Nyangiri, et al.

     Lancet. 2013; 381:142-51

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180. 2013
     The distribution of haemoglobin C and its prevalence in newborns in Africa

     Piel, F. B. Howes, R. E. Patil, A. P. Nyangiri, et al.

     Sci Rep. 2013; 3:1671

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181. 2013
     Online biomedical resources for malaria-related red cell disorders

     Piel, F. B. Howes, R. E. Nyangiri, O. A. Moyes, et al.

     Hum Mutat. 2013; 34:937-44

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182. 2013
     Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions

     Piel, F. B. Hay, S. I. Gupta, S. Weatherall, et al.

     PLoS Med. 2013; 10:e1001484

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183. 2013
     The "difficult patient" conundrum in sickle cell disease in Kenya: complex sociopolitical problems need wide multidimensional solutions

     Marsh, V. Mocamah, G. Mabibo, E. Kombe, et al.

     Am J Bioeth. 2013; 13:20-2

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184. 2013
     Consulting communities on feedback of genetic findings in international health research: sharing sickle cell disease and carrier information in coastal Kenya

     Marsh, V. Kombe, F. Fitzpatrick, R. Williams, et al.

     BMC Med Ethics. 2013; 14:41

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185. 2013
     Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

     Lee, J. C. Espeli, M. Anderson, C. A. Linterman, et al.

     Cell. 2013; 155:57-69

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186. 2013
     The genetic risk of acute seizures in African children with falciparum malaria

     Kariuki, S. M. Rockett, K. Clark, T. G. Reyburn, et al.

     Epilepsia. 2013; 54:990-1001

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187. 2013
     Spatial distribution of G6PD deficiency variants across malaria-endemic regions

     Howes, R. E. Dewi, M. Piel, F. B. Monteiro, et al.

     Malar J. 2013; 12:418

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188. 2013
     Determinants of anemia among preschool children in rural, western Kenya

     Foote, E. M. Sullivan, K. M. Ruth, L. J. Oremo, et al.

     Am J Trop Med Hyg. 2013; 88:757-64

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189. 2013
     Imputation-based meta-analysis of severe malaria in three African populations

     Band, G. Le, Q. S. Jostins, L. Pirinen, et al.

     PLoS Genet. 2013; 9:e1003509

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190. 2013
     Routine paediatric sickle cell disease (SCD) outpatient care in a rural Kenyan hospital: utilization and costs

     Amendah, D. D. Mukamah, G. Komba, A. Ndila, et al.

     PLoS One. 2013; 8:e61130

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191. 2012
     World distribution, population genetics, and health burden of the hemoglobinopathies

     Williams, T. N. Weatherall, D. J.

     Cold Spring Harb Perspect Med. 2012; 2:a011692

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192. 2012
     Balancing act: haemoglobinopathies and malaria

     Williams, T. N.

     Lancet Infect Dis. 2012; 12:427-8

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193. 2012
     Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia

     Uyoga, S. Skorokhod, O. A. Opiyo, M. Orori, et al.

     Br J Haematol. 2012; 157:116-24

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194. 2012
     Profile: The Kilifi Health and Demographic Surveillance System (KHDSS)

     Scott, J. A. Bauni, E. Moisi, J. C. Ojal, et al.

     Int J Epidemiol. 2012; 41:650-7

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195. 2012
     The Jamaican historical experience of the impact of educational interventions on sickle cell disease child mortality

     Grosse, S. D. Atrash, H. K. Odame, I. Amendah, et al.

     Am J Prev Med. 2012; 42:e101-3

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196. 2012
     Investigating the potential for ethnic group harm in collaborative genomics research in Africa: is ethnic stigmatisation likely?

     de Vries, J. Jallow, M. Williams, T. N. Kwiatkowski, et al.

     Soc Sci Med. 2012; 75:1400-7

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197. 2011
     Sickle cell disease and malaria morbidity: a tale with two tails

     Williams, T. N. Obaro, S. K.

     Trends Parasitol. 2011; 27:315-20

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198. 2011
     How do hemoglobins S and C result in malaria protection?

     Williams, T. N.

     J Infect Dis. 2011; 204:1651-3

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199. 2011
     Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

     Scott, J. A. Berkley, J. A. Mwangi, I. Ochola, et al.

     Lancet. 2011; 378:1316-23

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200. 2011
     Manifestations of paediatric Leishmania infantum infections in Malta

     Pace, D. Williams, T. N. Grochowska, A. Betts, et al.

     Travel Med Infect Dis. 2011; 9:37-46

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201. 2011
     Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome

     Ochola, L. B. Siddondo, B. R. Ocholla, H. Nkya, et al.

     PLoS One. 2011; 6:e14741

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202. 2011
     Sensitivity of hospital-based surveillance for severe disease: a geographic information system analysis of access to care in Kilifi district, Kenya

     Moisi, J. C. Nokes, D. J. Gatakaa, H. Williams, et al.

     Bull World Health Organ. 2011; 89:102-11

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203. 2011
     Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis

     Moisi, J. C. Gatakaa, H. Berkley, J. A. Maitland, et al.

     Bull World Health Organ. 2011; 89:725-32, 732A

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204. 2011
     Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania

     Makani, J. Cox, S. E. Soka, D. Komba, et al.

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205. 2011
     Social autopsy: INDEPTH Network experiences of utility, process, practices, and challenges in investigating causes and contributors to mortality

     Kallander, K. Kadobera, D. Williams, T. N. Nielsen, et al.

     Popul Health Metr. 2011; 9:44

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206. 2011
     The global distribution of the Duffy blood group

     Howes, R. E. Patil, A. P. Piel, F. B. Nyangiri, et al.

     Nat Commun. 2011; 2:266

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207. 2011
     Sickle cell disease in Africa: a neglected cause of early childhood mortality

     Grosse, S. D. Odame, I. Atrash, H. K. Amendah, et al.

     Am J Prev Med. 2011; 41:S398-405

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208. 2011
     Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania

     Cox, S. E. Makani, J. Fulford, A. J. Komba, et al.

     Haematologica. 2011; 96:948-53

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209. 2011
     Validating physician-certified verbal autopsy and probabilistic modeling (InterVA) approaches to verbal autopsy interpretation using hospital causes of adult deaths

     Bauni, E. Ndila, C. Mochamah, G. Nyutu, et al.

     Popul Health Metr. 2011; 9:49

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210. 2010
     Preventable deaths in sickle-cell anaemia in African children - Authors' reply

     Williams, T.N. Uyoga, S. Macharia, A. Sharif, et al.

     Lancet. 2010; 375:461

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211. 2010
     A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus

     Willcocks, L. C. Carr, E. J. Niederer, H. A. Rayner, et al.

     Proc Natl Acad Sci U S A. 2010; 107:7881-5

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212. 2010
     Parvovirus B19 infection and severe anaemia in Kenyan children: a retrospective case control study

     Wildig, J. Cossart, Y. Peshu, N. Gicheru, et al.

     BMC Infect Dis. 2010; 10:88

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213. 2010
     The population genetics and dynamics of the thalassemias

     Weatherall, D. J. Williams, T. N. Allen, S. J. O'Donnell, et al.

     Hematol Oncol Clin North Am. 2010; 24:1021-31

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214. 2010
     Sickle-cell disease

     Rees, D. C. Williams, T. N. Gladwin, M. T.

     Lancet. 2010; 376:2018-31

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215. 2010
     Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

     Piel, F. B. Patil, A. P. Howes, R. E. Nyangiri, et al.

     Nat Commun. 2010; 1:104

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216. 2010
     Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya

     Olotu, A. Fegan, G. Williams, T. N. Sasi, et al.

     PLoS One. 2010; 5:e15569

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217. 2010
     Rotavirus genetic diversity, disease association, and temporal change in hospitalized rural Kenyan children

     Nokes, D. J. Peenze, I. Netshifhefhe, L. Abwao, et al.

     J Infect Dis. 2010; 202 Suppl:S180-6

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218. 2010
     Copy number, linkage disequilibrium and disease association in the FCGR locus

     Niederer, H. A. Willcocks, L. C. Rayner, T. F. Yang, et al.

     Hum Mol Genet. 2010; 19:3282-94

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219. 2010
     Geographic access to care is not a determinant of child mortality in a rural Kenyan setting with high health facility density

     Moisi, J. C. Gatakaa, H. Noor, A. M. Williams, et al.

     BMC Public Health. 2010; 10:142

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220. 2010
     High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

     McAuley, C. F. Webb, C. Makani, J. Macharia, et al.

     Blood. 2010; 116:1663-8

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221. 2010
     Experiences with community engagement and informed consent in a genetic cohort study of severe childhood diseases in Kenya

     Marsh, V. M. Kamuya, D. M. Mlamba, A. M. Williams, et al.

     BMC Med Ethics. 2010; 11:13

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222. 2010
     Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization

     Makani, J. Komba, A. N. Cox, S. E. Oruo, et al.

     Blood. 2010; 115:215-20

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223. 2010
     CISH and susceptibility to infectious diseases

     Khor, C. C. Vannberg, F. O. Chapman, S. J. Guo, et al.

     N Engl J Med. 2010; 362:2092-101

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224. 2010
     Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis

     Idro, R. Gwer, S. Williams, T. N. Otieno, et al.

     PLoS One. 2010; 5:e14001

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225. 2010
     Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study

     Chapman, S. J. Khor, C. C. Vannberg, F. O. Rautanen, et al.

     Crit Care. 2010; 14:R227

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226. 2010
     NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations

     Chapman, S. J. Khor, C. C. Vannberg, F. O. Rautanen, et al.

     Genes Immun. 2010; 11:319-25

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227. 2010
     Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya

     Bejon, P. Williams, T. N. Liljander, A. Noor, et al.

     PLoS Med. 2010; 7:e1000304

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228. 2009
     Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study

     Williams, T. N. Uyoga, S. Macharia, A. Ndila, et al.

     Lancet. 2009; 374:1364-70

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229. 2009
     Human genetic resistance to malaria

     Williams, T. N.

     Adv Exp Med Biol. 2009; 634:243-53

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230. 2009
     Population Genetics and Global Health Burden

     Weatherall, D. J. Williams, T. N.

     Disorders of Hemoglobin. 2009

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231. 2009
     An observational study of children with sickle cell disease in Kilifi, Kenya

     Sadarangani, M. Makani, J. Komba, A. N. Ajala-Agbo, et al.

     Br J Haematol. 2009; 146:675-82

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232. 2009
     Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations

     Mangano, V. D. Clark, T. G. Auburn, S. Campino, et al.

     PLoS One. 2009; 4:e4206

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233. 2009
     Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness

     Makani, J. Kirkham, F. J. Komba, A. Ajala-Agbo, et al.

     Br J Haematol. 2009; 145:529-32

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234. 2009
     Homozygosity and risk of childhood death due to invasive bacterial disease

     Lyons, E. J. Amos, W. Berkley, J. A. Mwangi, et al.

     BMC Med Genet. 2009; 10:55

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235. 2009
     Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya

     Komba, A. N. Makani, J. Sadarangani, M. Ajala-Agbo, et al.

     Clin Infect Dis. 2009; 49:216-22

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236. 2009
     Genome-wide and fine-resolution association analysis of malaria in West Africa

     Jallow, M. Teo, Y. Y. Small, K. S. Rockett, et al.

     Nat Genet. 2009; 41:657-65

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237. 2009
     Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

     Fry, A. E. Ghansa, A. Small, K. S. Palma, et al.

     Hum Mol Genet. 2009; 18:2683-92

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238. 2009
     Epidemiological studies of the 'non-specific effects' of vaccines: I--data collection in observational studies

     Fine, P. E. Williams, T. N. Aaby, P. Kallander, et al.

     Trop Med Int Health. 2009; 14:969-76

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239. 2009
     Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection

     Farnert, A. Williams, T. N. Mwangi, T. W. Ehlin, et al.

     J Infect Dis. 2009; 200:1166-75

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240. 2009
     Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations

     Clark, T. G. Diakite, M. Auburn, S. Campino, et al.

     J Infect Dis. 2009; 199:569-75

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241. 2009
     HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria

     Berkley, J. A. Bejon, P. Mwangi, T. Gwer, et al.

     Clin Infect Dis. 2009; 49:336-43

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242. 2008
     Relationship between exposure, clinical malaria, and age in an area of changing transmission intensity

     O'Meara, W. P. Mwangi, T. W. Williams, T. N. McKenzie, et al.

     Am J Trop Med Hyg. 2008; 79:185-91

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243. 2008
     Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya

     Nokes, D. J. Abwao, J. Pamba, A. Peenze, et al.

     PLoS Med. 2008; 5:e153

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244. 2008
     Evidence for over-dispersion in the distribution of clinical malaria episodes in children

     Mwangi, T. W. Fegan, G. Williams, T. N. Kinyanjui, et al.

     PLoS One. 2008; 3:e2196

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245. 2008
     Acquisition of growth-inhibitory antibodies against blood-stage Plasmodium falciparum

     McCallum, F. J. Persson, K. E. Mugyenyi, C. K. Fowkes, et al.

     PLoS One. 2008; 3:e3571

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246. 2008
     Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children

     Mackintosh, C. L. Mwangi, T. Kinyanjui, S. M. Mosobo, et al.

     Int J Parasitol. 2008; 38:1445-54

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247. 2008
     Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1

     Mackintosh, C. L. Christodoulou, Z. Mwangi, T. W. Kortok, et al.

     Malar J. 2008; 7:155

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248. 2008
     Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area

     Idro, R. Williams, T. N. Gwer, S. Uyoga, et al.

     Epilepsy Res. 2008; 81:114-8

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249. 2008
     Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria

     Fry, A. E. Griffiths, M. J. Auburn, S. Diakite, et al.

     Hum Mol Genet. 2008; 17:567-76

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250. 2008
     Variation in the ICAM1 gene is not associated with severe malaria phenotypes

     Fry, A. E. Auburn, S. Diakite, M. Green, et al.

     Genes Immun. 2008; 9:462-9

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251. 2008
     Association of the GNAS locus with severe malaria

     Auburn, S. Diakite, M. Fry, A. E. Ghansah, et al.

     Hum Genet. 2008; 124:499-506

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252. 2008
     Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya

     Akech, S. O. Hassall, O. Pamba, A. Idro, et al.

     Malar J. 2008; 7:256

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253. 2007
     Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria

     Verra, F. Simpore, J. Warimwe, G. M. Tetteh, et al.

     PLoS One. 2007; 2:e978

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254. 2007
     Sickle cell disease in Africa: burden and research priorities

     Makani, J. Williams, T. N. Marsh, K.

     Ann Trop Med Parasitol. 2007; 101:3-14

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255. 2007
     Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus

     Khor, C. C. Vannberg, F. O. Chapman, S. J. Walley, et al.

     Genes Immun. 2007; 8:570-6

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256. 2007
     A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

     Khor, C. C. Chapman, S. J. Vannberg, F. O. Dunne, et al.

     Nat Genet. 2007; 39:523-8

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257. 2007
     Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue

     Cordery, D. V. Kishore, U. Kyes, S. Shafi, et al.

     J Infect Dis. 2007; 195:905-12

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258. 2007
     Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa

     Beeson, J. G. Ndungu, F. Persson, K. E. Chesson, et al.

     Am J Trop Med Hyg. 2007; 77:22-8

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259. 2007
     The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya

     Atkinson, S. H. Mwangi, T. W. Uyoga, S. M. Ogada, et al.

     Clin Infect Dis. 2007; 44:802-9

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260. 2006
     Red blood cell defects and malaria

     Williams, T. N.

     Mol Biochem Parasitol. 2006; 149:121-7

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261. 2006
     Human red blood cell polymorphisms and malaria

     Williams, T. N.

     Curr Opin Microbiol. 2006; 9:388-94

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262. 2006
     The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya

     Wambua, S. Mwangi, T. W. Kortok, M. Uyoga, et al.

     PLoS Med. 2006; 3:e158

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263. 2006
     Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters

     Wambua, S. Mwacharo, J. Uyoga, S. Macharia, et al.

     Br J Haematol. 2006; 133:206-9

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264. 2006
     Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait

     Urban, B. C. Shafi, M. J. Cordery, D. V. Macharia, et al.

     Am J Trop Med Hyg. 2006; 74:578-84

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265. 2006
     The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria

     Urban, B. C. Cordery, D. Shafi, M. J. Bull, et al.

     Infect Immun. 2006; 74:6700-6

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266. 2006
     High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya

     Polley, S. D. Conway, D. J. Cavanagh, D. R. McBride, et al.

     Vaccine. 2006; 24:4233-46

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267. 2005
     Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya

     Williams, T. N. Wambua, S. Uyoga, S. Macharia, et al.

     Blood. 2005; 106:368-71

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268. 2005
     Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait

     Williams, T. N. Mwangi, T. W. Wambua, S. Peto, et al.

     Nat Genet. 2005; 37:1253-7

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269. 2005
     Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases

     Williams, T. N. Mwangi, T. W. Wambua, S. Alexander, et al.

     J Infect Dis. 2005; 192:178-86

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270. 2005
     An immune basis for malaria protection by the sickle cell trait

     Williams, T. N. Mwangi, T. W. Roberts, D. J. Alexander, et al.

     PLoS Med. 2005; 2:e128

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271. 2005
     Cytokine mRNA expression and iron status in children living in a malaria endemic area

     Nyakeriga, A. M. Williams, T. N. Marsh, K. Wambua, et al.

     Scand J Immunol. 2005; 61:370-5

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272. 2005
     Nutritional iron status in children with alpha+ thalassemia and the sickle cell trait in a malaria endemic area on the coast of Kenya

     Nyakeriga, A. M. Troye-Blomberg, M. Mwacharo, J. K. Wambua, et al.

     Haematologica. 2005; 90:552-4

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273. 2005
     Management of severe malaria in children: proposed guidelines for the United Kingdom

     Maitland, K. Nadel, S. Pollard, A. J. Williams, et al.

     BMJ. 2005; 331:337-43

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274. 2005
     Heritability of malaria in Africa

     Mackinnon, M. J. Mwangi, T. W. Snow, R. W. Marsh, et al.

     PLoS Med. 2005; 2:e340

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275. 2005
     A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

     Jenkins, N. E. Mwangi, T. W. Kortok, M. Marsh, et al.

     Clin Infect Dis. 2005; 41:1817-9

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276. 2005
     B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area

     Dorfman, J. R. Bejon, P. Ndungu, F. M. Langhorne, et al.

     J Infect Dis. 2005; 191:1623-30

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277. 2004
     Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria

     Polley, S. D. Mwangi, T. Kocken, C. H. Thomas, et al.

     Vaccine. 2004; 23:718-28

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278. 2004
     Iron deficiency and malaria among children living on the coast of Kenya

     Nyakeriga, A. M. Troye-Blomberg, M. Dorfman, J. R. Alexander, et al.

     J Infect Dis. 2004; 190:439-47

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279. 2004
     Malaria and nutritional status in children living on the coast of Kenya

     Nyakeriga, A. M. Troye-Blomberg, M. Chemtai, A. K. Marsh, et al.

     Am J Clin Nutr. 2004; 80:1604-10

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280. 2004
     Falciparum malaria: current therapeutic challenges

     Maitland, K. Makanga, M. Williams, T. N.

     Curr Opin Infect Dis. 2004; 17:405-12

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281. 2004
     HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia

     Maitland, K. Bunce, M. Harding, R. M. Barnardo, et al.

     Tissue Antigens. 2004; 64:678-86

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282. 2004
     The use of cryopreserved mature trophozoites in assessing antibody recognition of variant surface antigens of Plasmodium falciparum-infected erythrocytes

     Kinyanjui, S. M. Howard, T. Williams, T. N. Bull, et al.

     J Immunol Methods. 2004; 288:9-18

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283. 2003
     Reevaluation of flow cytometry for investigating antibody binding to the surface of Plasmodium falciparum trophozoite-infected red blood cells

     Williams, T. N. Newbold, C. I.

     Cytometry A. 2003; 56:96-103

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284. 2002
     The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes

     Williams, T. N. Weatherall, D. J. Newbold, C. I.

     Br J Haematol. 2002; 118:663-70

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