A complete list of publications by Dr. Ally Olotu. Use the filters to refine by year, journal or keyword.

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1. 2025
   Vaccine-induced responses to R21/Matrix-M - an analysis of samples from a phase 1b age de-escalation, dose-escalation trial

   Bundi, C. Bellamy, D. Kibwana, E. Nyamako, et al.

   Front Immunol. 2025; 16:1620366

   View abstract DOI PubMed
2. 2024
   Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023

   Kapulu, M. Manda-Taylor, L. Balasingam, S. Means, et al.

   Biologicals. 2024; 85:101747

   View abstract DOI PubMed
3. 2024
   Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial

   Datoo, M. S. Dicko, A. Tinto, H. Ouedraogo, et al.

   Lancet. 2024; 403:533-544

   View abstract DOI PubMed
4. 2024
   Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023

   Cavaleri, M. Kaslow, D. Boateng, E. Chen, et al.

   Biologicals. 2024; 85:101745

   View abstract DOI PubMed
5. 2023
   Sporozoite immunization: innovative translational science to support the fight against malaria

   Richie, T. L. Church, L. W. P. Murshedkar, T. Billingsley, et al.

   Expert Rev Vaccines. 2023; 22:964-1007

   View abstract DOI PubMed
6. 2023
   Pre-vaccination monocyte-to-lymphocyte ratio as a biomarker for the efficacy of malaria candidate vaccines: A subgroup analysis of pooled clinical trial data

   Nyandele, J. P. Kibondo, U. A. Issa, F. Van Geertruyden, et al.

   PLoS One. 2023; 18:e0291244

   View abstract DOI PubMed
7. 2022
   The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea

   Manock, S. R. Nsue, V. U. Olotu, A. Mpina, et al.

   Trans R Soc Trop Med Hyg. 2022; 116:745-749

   View abstract DOI PubMed
8. 2022
   Malaria hospitalisation in East Africa: age, phenotype and transmission intensity

   Kamau, A. Paton, R. S. Akech, S. Mpimbaza, et al.

   BMC Med. 2022; 20:28

   View abstract DOI PubMed
9. 2020
   Providing Ancillary Care in Clinical Research: A Case of Diffuse Large B-Cell Lymphoma during a Malaria Vaccine Trial in Equatorial Guinea

   Manock, S. R. Mtoro, A. Urbano Nsue Ndong, V. Olotu, et al.

   Am J Trop Med Hyg. 2020; 104:695-699

   View abstract DOI PubMed
10. 2020
    The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa

    Billingsley, P. F. Maas, C. D. Olotu, A. Schwabe, et al.

    Am J Trop Med Hyg. 2020; 103:947-954

    View abstract DOI PubMed
11. 2019
    Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis

    Mwanga, E. P. Minja, E. G. Mrimi, E. Jimenez, et al.

    Malar J. 2019; 18:341

    View abstract DOI PubMed
12. 2017
    High Sporozoite Antibody Titers in Conjunction with Microscopically Detectable Blood Infection Display Signatures of Protection from Clinical Malaria

    Offeddu, V. Olotu, A. Osier, F. Marsh, et al.

    Front Immunol. 2017; 8:488

    View abstract DOI PubMed
13. 2017
    Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study

    Gitaka, J. Ogwang, C. Ngari, M. Akoo, et al.

    PLoS One. 2017; 12:e0177382

    View abstract DOI PubMed
14. 2016
    Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children

    Olotu, A. Fegan, G. Wambua, J. Nyangweso, et al.

    N Engl J Med. 2016; 374:2519-29

    View abstract DOI PubMed
15. 2015
    Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity

    Rono, J. Farnert, A. Murungi, L. Ojal, et al.

    BMC Med. 2015; 13:114

    View abstract DOI PubMed
16. 2014
    A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

    White, M. T. Bejon, P. Olotu, A. Griffin, et al.

    BMC Med. 2014; 12:117

    View abstract DOI PubMed
17. 2014
    Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children

    Olotu, A. Clement, F. Jongert, E. Vekemans, et al.

    PLoS One. 2014; 9:e115126

    View abstract DOI PubMed
18. 2014
    CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria

    Gitau, E. N. Tuju, J. Karanja, H. Stevenson, et al.

    J Immunol. 2014; 192:1753-61

    View abstract DOI PubMed
19. 2013
    The relationship between RTS,S vaccine-induced antibodies, CD4(+) T cell responses and protection against Plasmodium falciparum infection

    White, M. T. Bejon, P. Olotu, A. Griffin, et al.

    PLoS One. 2013; 8:e61395

    View abstract DOI PubMed
20. 2013
    Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

    Warimwe, G. M. Fletcher, H. A. Olotu, A. Agnandji, et al.

    BMC Med. 2013; 11:184

    View abstract DOI PubMed
21. 2013
    Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure

    Roetynck, S. Olotu, A. Simam, J. Marsh, et al.

    PLoS One. 2013; 8:e55195

    View abstract DOI PubMed
22. 2013
    Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure

    Olotu, A. Fegan, G. Wambua, J. Nyangweso, et al.

    N Engl J Med. 2013; 368:1111-20

    View abstract DOI PubMed
23. 2013
    Feedback of research findings for vaccine trials: experiences from two malaria vaccine trials involving healthy children on the Kenyan Coast

    Gikonyo, C. Kamuya, D. Mbete, B. Njuguna, et al.

    Dev World Bioeth. 2013; 13:48-56

    View abstract DOI PubMed
24. 2013
    Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data

    Bejon, P. White, M. T. Olotu, A. Bojang, et al.

    Lancet Infect Dis. 2013; 13:319-27

    View abstract DOI PubMed
25. 2012
    A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

    Rts, S. Clinical Trials Partnership Agnandji, S. T. Lell, B. Fernandes, et al.

    N Engl J Med. 2012; 367:2284-95

    View abstract DOI PubMed
26. 2012
    Estimating individual exposure to malaria using local prevalence of malaria infection in the field

    Olotu, A. Fegan, G. Wambua, J. Nyangweso, et al.

    PLoS One. 2012; 7:e32929

    View abstract DOI PubMed
27. 2012
    Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children

    Ndungu, F. M. Olotu, A. Mwacharo, J. Nyonda, et al.

    Proc Natl Acad Sci U S A. 2012; 109:8247-52

    View abstract DOI PubMed
28. 2012
    A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E

    Ndungu, F. M. Mwacharo, J. Kimani, D. Kai, et al.

    PLoS One. 2012; 7:e52870

    View abstract DOI PubMed
29. 2012
    Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya

    Midega, J. T. Smith, D. L. Olotu, A. Mwangangi, et al.

    Nat Commun. 2012; 3:674

    View abstract DOI PubMed
30. 2012
    Approaching the community about screening children for a multicentre malaria vaccine trial

    Lang, T. A. Gould, J. von Seidlein, L. Lusingu, et al.

    Int Health. 2012; 4:47-54

    View abstract DOI PubMed
31. 2012
    Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya

    Ibison, F. Olotu, A. Muema, D. M. Mwacharo, et al.

    PLoS One. 2012; 7:e52939

    View abstract DOI PubMed
32. 2011
    First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

    Rts, S. Clinical Trials Partnership Agnandji, S. T. Lell, B. Soulanoudjingar, et al.

    N Engl J Med. 2011; 365:1863-75

    View abstract DOI PubMed
33. 2011
    Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria

    Olotu, A. Moris, P. Mwacharo, J. Vekemans, et al.

    PLoS One. 2011; 6:e25786

    View abstract DOI PubMed
34. 2011
    Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial

    Olotu, A. Lusingu, J. Leach, A. Lievens, et al.

    Lancet Infect Dis. 2011; 11:102-9

    View abstract DOI PubMed
35. 2011
    Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast

    Kariuki, S. M. Ikumi, M. Ojal, J. Sadarangani, et al.

    Brain. 2011; 134:1519-28

    View abstract DOI PubMed
36. 2011
    Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites

    Bejon, P. Turner, L. Lavstsen, T. Cham, et al.

    PLoS One. 2011; 6:e21711

    View abstract DOI PubMed
37. 2011
    Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children

    Bejon, P. Cook, J. Bergmann-Leitner, E. Olotu, et al.

    J Infect Dis. 2011; 204:9-18

    View abstract DOI PubMed
38. 2010
    Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya

    Olotu, A. Fegan, G. Williams, T. N. Sasi, et al.

    PLoS One. 2010; 5:e15569

    View abstract DOI PubMed
39. 2010
    Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children

    Lusingu, J. Olotu, A. Leach, A. Lievens, et al.

    PLoS One. 2010; 5:e14090

    View abstract DOI PubMed
40. 2010
    Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya

    Bejon, P. Williams, T. N. Liljander, A. Noor, et al.

    PLoS Med. 2010; 7:e1000304

    View abstract DOI PubMed
41. 2009
    Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children

    Olotu, A. Ndiritu, M. Ismael, M. Mohammed, et al.

    Resuscitation. 2009; 80:69-72

    View abstract DOI PubMed
42. 2009
    Response to "Poor control vaccines in two randomised trials of malaria vaccine?"

    Bejon, P. Abdulla, S. Lusingu, J. Olotu, et al.

    Vaccine. 2009; 27:4745-6

    View abstract DOI PubMed
43. 2008
    Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age

    Bejon, P. Lusingu, J. Olotu, A. Leach, et al.

    N Engl J Med. 2008; 359:2521-32

    View abstract DOI PubMed